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PE20151671A1 - Inhibidores macrociclicos de las interacciones proteina/proteina de proteina de muerte programada 1 (pd-1)/ligando de muerte programada 1 (pd-l1) y cumulo de diferenciacion 80 (b7-1) cd80 (b7-1)/ligando de muerte programada 1 (pd-l1) - Google Patents

Inhibidores macrociclicos de las interacciones proteina/proteina de proteina de muerte programada 1 (pd-1)/ligando de muerte programada 1 (pd-l1) y cumulo de diferenciacion 80 (b7-1) cd80 (b7-1)/ligando de muerte programada 1 (pd-l1)

Info

Publication number
PE20151671A1
PE20151671A1 PE2015001957A PE2015001957A PE20151671A1 PE 20151671 A1 PE20151671 A1 PE 20151671A1 PE 2015001957 A PE2015001957 A PE 2015001957A PE 2015001957 A PE2015001957 A PE 2015001957A PE 20151671 A1 PE20151671 A1 PE 20151671A1
Authority
PE
Peru
Prior art keywords
death
programmed
protein
methyl
cumulum
Prior art date
Application number
PE2015001957A
Other languages
English (en)
Inventor
Michael Matthew Miller
Claudio Mapelli
Martin Patrick Allen
Michael S Bowsher
Kenneth M Boy
Eric P Gillis
David R Langley
Eric Mull
Nishith Sanghvi
Li-Qiang Sun
Daniel J Tenney
Kap-Sun Yeung
Juliang Zhu
Patrick C Reid
Paul Michael Scola
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20151671A1 publication Critical patent/PE20151671A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N2800/00—Detection or diagnosis of diseases
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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Abstract

SE REFIERE A PEPTIDOS MACROCICLICOS DE FORMULA (I) O SALES DEL MISMO FARMACEUTICAMENTE ACEPTABLES, QUE SE CARACTERIZAN PORQUE A ES -CH[C(O)NH2]-(CH2)n-CH2-S-CH2-*, -CH[C(O)NH2]-(CH2)n-CH2-S(O)-CH2-*, -CH[C(O)NH2]-(CH2)n-CH2-S(O)2-CH2-*, -CH[C(O)NH2]-(CH2)n-CH2-* O -CH[C(O)NH2]-(CH2)n-CH=CH-*, ENTRE OTROS, DONDE * INDICA EL PUNTO DE UNION A CARBONILO; n ES 0 o 1; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 Y R13 SON INDEPENDIENTEMENTE UNA CADENA LATERAL DE AMINOACIDO NO NATURAL, ENTRE OTROS; Ra, Re, Rj Y Rk SON INDEPENDIENTEMENTE H O METILO; Rc, Rf, Rh, Ri, Rm Y Rn SON H; Rb ES METILO; Rd ES H O METILO; Rg ES H O METILO; O Rb Y R2, Rd Y R4, O Rg Y R7, ENTRE OTROS, JUNTO CON LOS ATOMOS A LOS CUALES ESTAN UNIDOS FORMAN AZETIDINA, PIRROLIDINA, MORFOLINA, PIPERIDINA O PIPERAZINA, ENTRE OTROS. LOS PEPTIDOS MACROCICLICOS DE FORMULA (I) INHIBEN LA INTERACCION PROTEINA/PROTEINA PPD-1/PD-L1 Y PD-L1/CD80, POR LO CUAL SON UTILES EN LA TERAPIA DE VARIAS ENFERMEDADES, INCLUSIVE CANCER Y ENFERMEDADES INFECCIOSAS
PE2015001957A 2013-03-15 2014-03-13 Inhibidores macrociclicos de las interacciones proteina/proteina de proteina de muerte programada 1 (pd-1)/ligando de muerte programada 1 (pd-l1) y cumulo de diferenciacion 80 (b7-1) cd80 (b7-1)/ligando de muerte programada 1 (pd-l1) PE20151671A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361794589P 2013-03-15 2013-03-15
US201361918184P 2013-12-19 2013-12-19
US14/201,977 US9308236B2 (en) 2013-03-15 2014-03-10 Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions

Publications (1)

Publication Number Publication Date
PE20151671A1 true PE20151671A1 (es) 2015-11-12

Family

ID=50877649

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PE2015001957A PE20151671A1 (es) 2013-03-15 2014-03-13 Inhibidores macrociclicos de las interacciones proteina/proteina de proteina de muerte programada 1 (pd-1)/ligando de muerte programada 1 (pd-l1) y cumulo de diferenciacion 80 (b7-1) cd80 (b7-1)/ligando de muerte programada 1 (pd-l1)

Country Status (32)

Country Link
US (4) US9308236B2 (es)
EP (2) EP2970390B1 (es)
JP (1) JP6387082B2 (es)
KR (1) KR102229512B1 (es)
CN (1) CN105209479B (es)
AU (1) AU2014233675B2 (es)
CA (1) CA2905453C (es)
CL (1) CL2015002709A1 (es)
CY (1) CY1122571T1 (es)
DK (1) DK2970390T3 (es)
EA (1) EA030195B1 (es)
ES (1) ES2762580T3 (es)
HR (1) HRP20192337T1 (es)
HU (1) HUE048327T2 (es)
IL (1) IL241324B (es)
LT (1) LT2970390T (es)
MX (1) MX2015011731A (es)
MY (1) MY176746A (es)
NZ (1) NZ630535A (es)
PE (1) PE20151671A1 (es)
PH (1) PH12015502027A1 (es)
PL (1) PL2970390T3 (es)
PT (1) PT2970390T (es)
RS (1) RS59760B1 (es)
SG (1) SG11201506917YA (es)
SI (1) SI2970390T1 (es)
SM (1) SMT202000065T1 (es)
TN (1) TN2015000418A1 (es)
TW (1) TWI646112B (es)
UY (1) UY35448A (es)
WO (1) WO2014151634A1 (es)
ZA (1) ZA201506793B (es)

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