PE20141114A1 - Anticuerpos anti-mesotelina e inmunoconjugados - Google Patents
Anticuerpos anti-mesotelina e inmunoconjugadosInfo
- Publication number
- PE20141114A1 PE20141114A1 PE2013001438A PE2013001438A PE20141114A1 PE 20141114 A1 PE20141114 A1 PE 20141114A1 PE 2013001438 A PE2013001438 A PE 2013001438A PE 2013001438 A PE2013001438 A PE 2013001438A PE 20141114 A1 PE20141114 A1 PE 20141114A1
- Authority
- PE
- Peru
- Prior art keywords
- hvr
- seq
- immunoconjugates
- mesothelin antibodies
- antibody
- Prior art date
Links
- 229940127121 immunoconjugate Drugs 0.000 title abstract 2
- 102000003735 Mesothelin Human genes 0.000 abstract 1
- 108090000015 Mesothelin Proteins 0.000 abstract 1
- 230000016784 immunoglobulin production Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
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- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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- Toxicology (AREA)
Abstract
REFERIDO A UN ANTICUERPO QUE SE UNE A MESOTELINA, QUE COMPRENDE: A) (i) HVR-H1 DE SEQ ID N�20, (ii) HVR-H2 DE SEQ ID N�21, (iii) HVR-H3 DE SEQ ID N� 22, (iv) HVR-L1 DE SEQ ID 17, (v) HVR-L2 DE SEQ ID N� 18, (vi) HVR-L3 DE SEQ ID N� 19; B) (i) HVR-H1 DE SEQ ID N� 36, (ii) HVR-H2 DE SEQ ID N� 37, (iii) HVR-H3 DE SEQ ID 39, (iv) HVR-L1 DE SEQ ID N� 33, (v) HVR-L2 DE SEQ ID N�34, Y (vi) HVR-L3 DE SEQ ID N�35 O C) HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2 Y HVR-L3 DEL ANTICUERPO PRODUCIDO POR EL HIBRIDOMA 19C3 QUE POSEE EL ACCESO DE ATCC N� PTA-11464. REFERIDO ADEMAS A UN ACIDO NUCLEICO, UNA CELULA HUESPED, UN METODO DE PRODUCCION DEL ANTICUERPO, UN INMUNOCONJUGADO Y UNA FORMULACION FARMACEUTICA
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