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PE20120060A1 - PHARMACEUTICAL COMPOSITIONS INCLUDING A COMBINATION OF HUMAN INSULIN Gly (A21) -Arg (B31) Arg (B32) and DesProexendin-4 (1-39) -Lys6-NH2 - Google Patents

PHARMACEUTICAL COMPOSITIONS INCLUDING A COMBINATION OF HUMAN INSULIN Gly (A21) -Arg (B31) Arg (B32) and DesProexendin-4 (1-39) -Lys6-NH2

Info

Publication number
PE20120060A1
PE20120060A1 PE2011000891A PE2011000891A PE20120060A1 PE 20120060 A1 PE20120060 A1 PE 20120060A1 PE 2011000891 A PE2011000891 A PE 2011000891A PE 2011000891 A PE2011000891 A PE 2011000891A PE 20120060 A1 PE20120060 A1 PE 20120060A1
Authority
PE
Peru
Prior art keywords
arg
human insulin
insulin
lys6
desproexendin
Prior art date
Application number
PE2011000891A
Other languages
Spanish (es)
Inventor
Ulrich Werner
Barbel Rotthauser
Christopher James Smith
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42077330&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120060(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102008051834A external-priority patent/DE102008051834A1/en
Priority claimed from DE102008053048A external-priority patent/DE102008053048A1/en
Priority claimed from DE102009038210A external-priority patent/DE102009038210A1/en
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PE20120060A1 publication Critical patent/PE20120060A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA A UNA COMPOSICION FARMACEUTICA QUE COMPRENDE UNA INSULINA Y UN AGONISTA DE GLP-1, DONDE LA INSULINA ES Gly(A21)-Arg(B31)-Arg(B32) INSULINA HUMANA Lys^B28Pro^B29 INSULINA HUMANA, B28 Asp INSULINA HUMANA O B29Lys(epsilon-TETRADECANOIL) O desB30 INSULINA HUMANA Y EL AGONISTA DE GLP-1 ES EXENDINA-4, EXENDINA-3, desPro36EXENDINA-4(1-39)-Lys6-NH2, ENTRE OTROS. DICHA COMPOSICION ES UTIL EN EL TRATAMIENTO DE LA DIABETES TIPO 1 O 2, PARA AJUSTAR LA CONCENTRACION DE LA GLUCOSA SANGUINEA EN AYUNAS, POSPRANDIAL Y/O POSABSORTIVA, PARA MEJORAR LA TOLERANCIA A LA GLUCOSA, ENTRE OTRASREFERRED TO A PHARMACEUTICAL COMPOSITION INCLUDING AN INSULIN AND A GLP-1 AGONIST, WHERE INSULIN IS Gly (A21) -Arg (B31) -Arg (B32) HUMAN INSULIN Lys ^ B28Pro ^ B29 HUMAN INSULIN, B28 Asp INSULIN, HUMAN B29Lys (epsilon-TETRADECANOIL) OR desB30 HUMAN INSULIN AND THE GLP-1 AGONIST IS EXENDIN-4, EXENDIN-3, desPro36EXENDIN-4 (1-39) -Lys6-NH2, AMONG OTHERS. SUCH COMPOSITION IS USEFUL IN THE TREATMENT OF TYPE 1 OR 2 DIABETES, TO ADJUST THE CONCENTRATION OF BLOOD GLUCOSE IN FASTING, POST-PRANDIAL AND / OR POST-ABSORPTIVE, TO IMPROVE GLUCOSE TOLERANCE, AMONG OTHERS

PE2011000891A 2008-10-17 2009-10-09 PHARMACEUTICAL COMPOSITIONS INCLUDING A COMBINATION OF HUMAN INSULIN Gly (A21) -Arg (B31) Arg (B32) and DesProexendin-4 (1-39) -Lys6-NH2 PE20120060A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102008051834A DE102008051834A1 (en) 2008-10-17 2008-10-17 Drug, useful e.g. for treating diabetes, preferably type-I or II and for controlling fasting, postprandial and/or postabsorptive plasma glucose concentration, comprises insulin and glucagon-like peptide-1 agonist
DE102008053048A DE102008053048A1 (en) 2008-10-24 2008-10-24 Medicament, useful e.g. for treating diabetes, controlling fasting, postprandial or postabsorptive blood glucose concentration in diabetic patients and improving glucose tolerance, comprises insulin and glucagon-like peptide-1 agonist
DE102009038210A DE102009038210A1 (en) 2009-08-20 2009-08-20 Combination of an insulin and a GLP-1 agonist

Publications (1)

Publication Number Publication Date
PE20120060A1 true PE20120060A1 (en) 2012-02-23

Family

ID=42077330

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000891A PE20120060A1 (en) 2008-10-17 2009-10-09 PHARMACEUTICAL COMPOSITIONS INCLUDING A COMBINATION OF HUMAN INSULIN Gly (A21) -Arg (B31) Arg (B32) and DesProexendin-4 (1-39) -Lys6-NH2

Country Status (39)

Country Link
US (6) US9526764B2 (en)
EP (3) EP2349324B1 (en)
JP (2) JP5731981B2 (en)
KR (3) KR101939557B1 (en)
CN (3) CN105396126A (en)
AR (1) AR073872A1 (en)
AU (1) AU2009305472B2 (en)
BR (2) BRPI0920881B1 (en)
CA (2) CA2740685C (en)
CL (1) CL2011000851A1 (en)
CO (1) CO6361944A2 (en)
CR (2) CR20170369A (en)
CY (1) CY1119952T1 (en)
DK (2) DK2349324T3 (en)
DO (1) DOP2011000104A (en)
EC (1) ECSP11010986A (en)
ES (3) ES2650621T3 (en)
HK (1) HK1222568A1 (en)
HN (1) HN2011001021A (en)
HR (2) HRP20171894T1 (en)
HU (3) HUE068164T2 (en)
IL (2) IL212258A (en)
LT (2) LT3228320T (en)
MA (1) MA32703B1 (en)
MX (2) MX344293B (en)
NI (1) NI201100068A (en)
NZ (1) NZ592283A (en)
PA (1) PA8845901A1 (en)
PE (1) PE20120060A1 (en)
PL (3) PL2349324T3 (en)
PT (3) PT3677275T (en)
RS (2) RS56632B1 (en)
RU (1) RU2532378C2 (en)
SI (2) SI2349324T1 (en)
TN (1) TN2011000160A1 (en)
TW (1) TWI494121B (en)
UY (1) UY32183A (en)
WO (1) WO2010043566A2 (en)
ZA (1) ZA201102400B (en)

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EP3677275A1 (en) 2020-07-08
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