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PE20120054A1 - COMPUESTOS DERIVADOS DE 4,8-DIHIDRO-4,7-METANO-7H-PIRAZOLO[3,4-e][1,3]DIAZEPINA-6(5H)-ONA CON ACTIVIDAD ANTIBACTERIANA - Google Patents

COMPUESTOS DERIVADOS DE 4,8-DIHIDRO-4,7-METANO-7H-PIRAZOLO[3,4-e][1,3]DIAZEPINA-6(5H)-ONA CON ACTIVIDAD ANTIBACTERIANA

Info

Publication number
PE20120054A1
PE20120054A1 PE2011000846A PE2011000846A PE20120054A1 PE 20120054 A1 PE20120054 A1 PE 20120054A1 PE 2011000846 A PE2011000846 A PE 2011000846A PE 2011000846 A PE2011000846 A PE 2011000846A PE 20120054 A1 PE20120054 A1 PE 20120054A1
Authority
PE
Peru
Prior art keywords
diazepine
dihydro
methane
pyrazole
antibacterial activity
Prior art date
Application number
PE2011000846A
Other languages
English (en)
Inventor
Benoît Ledoussal
Marie-Edith Gourdel
Emilie Renaud
Camille Pierres
Adel Kebsi
Original Assignee
Novexel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40530144&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120054(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novexel filed Critical Novexel
Publication of PE20120054A1 publication Critical patent/PE20120054A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE: R1 ES H, -(CH2)m-NH2-, -(CH2)m-NH(C1-C6)ALC; m ES 1 O 2; R2 Y R3 FORMAN JUNTOS UN HETEROCICLO NITROGENADO AROMATICO DE 5 VERTICES QUE CONTIENE 1 A 3 ATOMOS DE NITROGENO TAL COMO PIRAZOLILO; R5 SE SELECCIONA DE LOS GRUPOS OSO3H, OCFHCO2H Y OCF2CO2H. SON COMPUESTOS PREFERIDOS TRANS 8-(AMINOMETIL)-2-(2-AMINO-ETIL-CARBAMOIL)-4,8-DIHIDRO-5-(SULFOXI)-4,7-METANO-7H-PIRAZOLO[3,4-e][1,3]DIAZEPINA-6(5H)-ONA; TRANS 8-(GUANIDINOMETIL)-2-CARBAMOIL-4,8-DIHIDRO-(SULFOXI)-4,7-METANO-7H-PIRAZOLO[3,4e][1,3]DIAZEPINA-6(5H)-ONA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON POLICLICOS EN FORMA ISOMERA O DIASTEREOISOMERAS UTILES EN EL TRAMIENTO DE INFECCIONES BACTERIANAS
PE2011000846A 2008-10-10 2009-07-29 COMPUESTOS DERIVADOS DE 4,8-DIHIDRO-4,7-METANO-7H-PIRAZOLO[3,4-e][1,3]DIAZEPINA-6(5H)-ONA CON ACTIVIDAD ANTIBACTERIANA PE20120054A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0805602A FR2937034B1 (fr) 2008-10-10 2008-10-10 Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens

Publications (1)

Publication Number Publication Date
PE20120054A1 true PE20120054A1 (es) 2012-01-26

Family

ID=40530144

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000846A PE20120054A1 (es) 2008-10-10 2009-07-29 COMPUESTOS DERIVADOS DE 4,8-DIHIDRO-4,7-METANO-7H-PIRAZOLO[3,4-e][1,3]DIAZEPINA-6(5H)-ONA CON ACTIVIDAD ANTIBACTERIANA

Country Status (19)

Country Link
US (1) US8148366B2 (es)
EP (2) EP2853534A1 (es)
JP (1) JP2012505195A (es)
KR (1) KR20110067140A (es)
CN (1) CN102216307B (es)
AU (1) AU2009302149A1 (es)
BR (1) BRPI0919807A2 (es)
CA (1) CA2739776A1 (es)
CL (1) CL2011000784A1 (es)
CO (1) CO6382121A2 (es)
EA (1) EA201170546A1 (es)
EC (1) ECSP11010962A (es)
FR (1) FR2937034B1 (es)
IL (1) IL212179A0 (es)
MX (1) MX2011003811A (es)
NZ (1) NZ592168A (es)
PE (1) PE20120054A1 (es)
WO (1) WO2010041108A1 (es)
ZA (1) ZA201102497B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
DK2748165T3 (en) * 2011-08-27 2016-12-19 Wockhardt Ltd 1,6-diazabicyclo [3,2,1] octane-7-ON DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS
AR090539A1 (es) 2012-04-02 2014-11-19 Astrazeneca Ab COMPUESTOS INHIBIDORES DE b LACTAMASA
RU2016113755A (ru) * 2013-10-11 2017-11-16 Вокхардт Лимитед Азотсодержащие соединения и их применение
EA033829B1 (ru) 2014-11-17 2019-11-29 Entasis Therapeutics Ltd Комбинированная терапия для лечения устойчивых бактериальных инфекций
US10501481B2 (en) * 2015-04-03 2019-12-10 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
SMT202200397T1 (it) 2016-09-16 2022-11-18 Entasis Therapeutics Ltd Composti inibitori di beta-lattamasi
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
HUE057592T2 (hu) * 2017-05-08 2022-05-28 Entasis Therapeutics Inc Vegyületek és eljárások bakteriális fertõzések kezelésére
WO2019093450A1 (ja) * 2017-11-10 2019-05-16 塩野義製薬株式会社 ジアザビシクロオクタン誘導体
CN118271319B (zh) * 2022-12-30 2025-02-28 成都四面体药物研究有限公司 一种β-内酰胺酶抑制剂含脲双环化合物、其制备方法及其用途
WO2025031214A1 (zh) * 2023-08-08 2025-02-13 成都四面体药物研究有限公司 一种含脲三环的β-内酰胺酶抑制剂、其制备方法及其用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ503740A (en) 1997-09-15 2002-09-27 Procter & Gamble Antimicrobial quinolones, their compositions and uses
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
FR2812635B1 (fr) 2000-08-01 2002-10-11 Aventis Pharma Sa Nouveaux composes heterocycliques, preparation et utilisation comme medicaments notamment comme anti- bacteriens
IL155679A0 (en) 2000-12-14 2003-11-23 Procter & Gamble Antimicrobial quinolones
WO2002048143A2 (en) 2000-12-14 2002-06-20 The Procter & Gamble Company Antimicrobial 2-pyridones, their compositions and uses
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
FR2833596B1 (fr) 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
FR2835186B1 (fr) * 2002-01-28 2006-10-20 Aventis Pharma Sa Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases
US6900224B2 (en) 2002-07-31 2005-05-31 The Procter & Gamble Company Antimicrobial quinolones, their compositions and uses
FR2844273B1 (fr) 2002-09-05 2008-04-04 Aventis Pharma Sa Nouveaux composes heterocycliques, procede et intermediaires de preparation et utilisation comme medicament, notamment comme inhibiteurs de beta-lactamases et anti-bacteriens.
FR2844270B1 (fr) 2002-09-11 2006-05-19 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent
FR2844268B1 (fr) 2002-09-11 2004-10-22 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent
FR2848210B1 (fr) * 2002-12-06 2007-10-19 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases
US7439253B2 (en) * 2002-12-06 2008-10-21 Novexel Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors
US7232833B2 (en) 2003-03-28 2007-06-19 Novexel 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
FR2914923B1 (fr) * 2007-04-12 2013-06-14 Novexel Nouveaux composes heterocycliques azotes,leur preparation et leur utilisation comme medicaments antibacteriens.

Also Published As

Publication number Publication date
BRPI0919807A2 (pt) 2015-12-22
JP2012505195A (ja) 2012-03-01
FR2937034A1 (fr) 2010-04-16
ZA201102497B (en) 2011-12-28
US20100093784A1 (en) 2010-04-15
EP2358722A1 (fr) 2011-08-24
CO6382121A2 (es) 2012-02-15
NZ592168A (en) 2013-03-28
MX2011003811A (es) 2011-07-29
EP2853534A1 (fr) 2015-04-01
EA201170546A1 (ru) 2011-12-30
CN102216307B (zh) 2015-02-25
ECSP11010962A (es) 2011-05-31
WO2010041108A1 (fr) 2010-04-15
CN102216307A (zh) 2011-10-12
FR2937034B1 (fr) 2012-11-23
CA2739776A1 (fr) 2010-04-15
US8148366B2 (en) 2012-04-03
KR20110067140A (ko) 2011-06-21
IL212179A0 (en) 2011-06-30
AU2009302149A1 (en) 2010-04-15
CL2011000784A1 (es) 2011-10-07

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