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PE20091811A1 - DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1 - Google Patents

DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1

Info

Publication number
PE20091811A1
PE20091811A1 PE2009000571A PE2009000571A PE20091811A1 PE 20091811 A1 PE20091811 A1 PE 20091811A1 PE 2009000571 A PE2009000571 A PE 2009000571A PE 2009000571 A PE2009000571 A PE 2009000571A PE 20091811 A1 PE20091811 A1 PE 20091811A1
Authority
PE
Peru
Prior art keywords
halogen
ona
hexahydro
imidazol
hsd1
Prior art date
Application number
PE2009000571A
Other languages
English (en)
Inventor
Jean Ackermann
Kurt Amrein
Bernd Kuhn
Alexander V Mayweg
Werner Neidhart
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40790778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091811(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20091811A1 publication Critical patent/PE20091811A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE IMIDAZOLIDINONA DE FORMULA (I) DONDE R1 ES BORNILO, FENILALQUILO, ADAMANTILO, ENTRE OTROS; R2 Y R3 JUNTO AL ATOMO DE N* Y DE C* FORMAN (E), (F), (G), ENTRE OTROS, DONDE UNO DE R7 Y R8 ES H O HALOGENO Y EL OTRO ES H, HALOGENO, OH, ALCOXI O ARILALCOXI; UNO DE R13 Y R14 ES H O HALOGENO Y EL OTRO ES H, HALOGENO, OH, ALCOXI O ARILALCOXI; R4 ES H, ALQUILO, CICLOALQUILO, ARILO, ENTRE OTROS; A ES CR5R6 O CARBONILO, DONDE R5 Y R6 SON CADA UNO H. SON COMPUESTOS PREFERIDOS: (S)-2-((Z)-5-HIDROXI-ADAMANTAN-2-IL)-7a-METIL-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, (S)-2-((Z)-5-HIDROXI-ADAMANTAN-2-IL)-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, (S)-2-FENIL-HEXAHIDRO-PIRROLO[1,2-c]IMIDAZOL-3-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA 11BETA-HIDROXIESTEROIDE-DESHIDROGENASA DE TIPO 1 (11BETA-HSD1) SIENDO UTILES PARA EL TRATAMIENTO DE LA DIABETES, OBESIDAD, DISLIPIDEMIA
PE2009000571A 2008-04-30 2009-04-27 DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1 PE20091811A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08155430 2008-04-30

Publications (1)

Publication Number Publication Date
PE20091811A1 true PE20091811A1 (es) 2009-11-21

Family

ID=40790778

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000571A PE20091811A1 (es) 2008-04-30 2009-04-27 DERIVADOS DE IMIDAZOLIDINONA COMO INHIBIDORES DE 11b-HSD1

Country Status (18)

Country Link
US (1) US8124636B2 (es)
EP (1) EP2280970B1 (es)
JP (1) JP2011520790A (es)
KR (1) KR20110008198A (es)
CN (1) CN102015706B (es)
AR (1) AR071512A1 (es)
AU (1) AU2009242248A1 (es)
BR (1) BRPI0910549A2 (es)
CA (1) CA2722487A1 (es)
CL (1) CL2009001019A1 (es)
ES (1) ES2445094T3 (es)
IL (1) IL208626A0 (es)
MX (1) MX2010011642A (es)
PE (1) PE20091811A1 (es)
RU (1) RU2538986C2 (es)
TW (1) TW200946535A (es)
WO (1) WO2009132986A1 (es)
ZA (1) ZA201007431B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
SA111320581B1 (ar) 2010-07-06 2014-06-17 استرازينيكا ايه بي مركبات (3-(4-(أمينو ميثيل ) فينوكسي أو فينيل ثيو) أزيتيدين -1- يل) (5- فينيل -1، 3، 4- أوكسا ديازول -2- يل) ميثانون
US8497288B2 (en) * 2011-05-09 2013-07-30 Hoffmann-La Roche Inc. Hexahydropyrroloimidazolone compounds
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP3235813A1 (en) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Aza-tetra-cyclo derivatives
AU2020363354A1 (en) * 2019-10-07 2022-04-21 D.E. Shaw Research, Llc Aryl heterobicyclic compounds as Kv1.3 potassium shaker channel blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3809390A1 (de) * 1988-03-16 1989-09-28 Schering Ag Perhydro-imidazopyridine und -pyrroloimidazole, verfahren zu ihrer herstellung und ihre verwendung als herbizide mittel
BR9917112A (pt) * 1998-12-24 2002-01-29 Fujisawa Pharmaceutical Co Compostos de imidazol e seu uso medicinal
WO2002096420A2 (en) * 2001-05-29 2002-12-05 Guilford Pharmaceuticals Inc. Method for treating nerve injury caused by surgery
TW200407324A (en) * 2002-05-17 2004-05-16 Bristol Myers Squibb Co Bicyclic modulators of androgen receptor function
ATE445600T1 (de) * 2004-08-30 2009-10-15 Janssen Pharmaceutica Nv Derivate von tricyclischem lactam als 11-beta- hydroxysteroid-dehydrogenase-inhibitoren
JPWO2008007664A1 (ja) * 2006-07-11 2009-12-10 武田薬品工業株式会社 二環性複素環化合物およびその用途
WO2008044656A1 (fr) * 2006-10-06 2008-04-17 Taisho Pharmaceutical Co., Ltd. Dérivé d'imidazolidinone
BRPI0717657A2 (pt) * 2006-10-19 2013-12-24 Hoffmann La Roche Compostos, processo para a preparação de um composto, composição farmacêutica que o compreende, usos de compostos, métodos para o tratamento e profilaxia de diabetes, obesidade, distúrbios alimentares, displidemia e hipertensão e profilaxia de diabetes do tipo ii

Also Published As

Publication number Publication date
CN102015706A (zh) 2011-04-13
CA2722487A1 (en) 2009-11-05
RU2010148534A (ru) 2012-06-10
KR20110008198A (ko) 2011-01-26
CL2009001019A1 (es) 2011-01-07
EP2280970B1 (en) 2014-01-08
AR071512A1 (es) 2010-06-23
EP2280970A1 (en) 2011-02-09
IL208626A0 (en) 2010-12-30
AU2009242248A1 (en) 2009-11-05
WO2009132986A1 (en) 2009-11-05
US20090275573A1 (en) 2009-11-05
CN102015706B (zh) 2014-07-16
RU2538986C2 (ru) 2015-01-10
BRPI0910549A2 (pt) 2016-04-19
US8124636B2 (en) 2012-02-28
ZA201007431B (en) 2013-03-27
TW200946535A (en) 2009-11-16
MX2010011642A (es) 2010-11-25
ES2445094T3 (es) 2014-02-28
JP2011520790A (ja) 2011-07-21

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