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PE20091681A1 - 3-indazolil-4-piridilisotiazoles - Google Patents

3-indazolil-4-piridilisotiazoles

Info

Publication number
PE20091681A1
PE20091681A1 PE2009000402A PE2009000402A PE20091681A1 PE 20091681 A1 PE20091681 A1 PE 20091681A1 PE 2009000402 A PE2009000402 A PE 2009000402A PE 2009000402 A PE2009000402 A PE 2009000402A PE 20091681 A1 PE20091681 A1 PE 20091681A1
Authority
PE
Peru
Prior art keywords
methyl
cyclopropancarboxyl
isothiazol
indazol
pyridin
Prior art date
Application number
PE2009000402A
Other languages
English (en)
Inventor
Thomas Charles Britton
Veronique Dehlinger
Adam Michael Fivush
Sean Patrick Hollinshead
Benjamin Paul Vokits
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20091681A1 publication Critical patent/PE20091681A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDO A UN COMPUESTO DE FORMULA (I), DONDE R1 ES H, ALQUILO C1-C3; R2 ES H, ALQUILO C1-C3, CICLOALQUILO C3-C5, FLUOROALQUILO C1-C3, ENTRE OTROS; R3 ES H, METILO. SON COMPUESTOS SELECCIONADOS: [4-(6-ETIL-PIRIDIN-2-IL)-3-(2-METIL-2H-INDAZOL-5-IL)-ISOTIAZOL-5-IL]-AMIDA DEL ACIDO (1R,2R)-2-METIL-CICLOPROPANCARBOXILICO; [4-(6-ISOPROPIL-PIRIDIN-2-IL)-3-(2-METIL-2H-INDAZOL-5-IL)-ISOTIAZOL-5-IL]-AMIDA DEL ACIDO (1R,2R)-2-METIL-CICLOPROPANCARBOXILICO; ENTRE OTROS. REFERIDO TAMBIEN A UN METODO DE PREPARACION Y A UNA FORMA FARMACEUTICA QUE LO CONTIENE. DICHO COMPUESTO ES ANTAGONISTA DE mGLUR5, SIENDO DE UTILIDAD EN EL TRATAMIENTO DE TRASTORNOS DE ANSIEDAD Y DEPRESIVOS
PE2009000402A 2008-04-04 2009-03-18 3-indazolil-4-piridilisotiazoles PE20091681A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4239408P 2008-04-04 2008-04-04

Publications (1)

Publication Number Publication Date
PE20091681A1 true PE20091681A1 (es) 2009-11-04

Family

ID=40725748

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000402A PE20091681A1 (es) 2008-04-04 2009-03-18 3-indazolil-4-piridilisotiazoles

Country Status (24)

Country Link
US (1) US7932274B2 (es)
EP (1) EP2276759B1 (es)
JP (1) JP5449320B2 (es)
KR (1) KR101247010B1 (es)
CN (1) CN101959883B (es)
AR (1) AR070986A1 (es)
AT (1) ATE529422T1 (es)
AU (1) AU2009232263B2 (es)
BR (1) BRPI0910692A2 (es)
CA (1) CA2720631C (es)
CL (1) CL2009000646A1 (es)
CY (1) CY1112118T1 (es)
DK (1) DK2276759T3 (es)
EA (1) EA018001B1 (es)
ES (1) ES2372677T3 (es)
HR (1) HRP20110784T1 (es)
JO (1) JO2775B1 (es)
MX (1) MX2010010781A (es)
PE (1) PE20091681A1 (es)
PL (1) PL2276759T3 (es)
PT (1) PT2276759E (es)
SI (1) SI2276759T1 (es)
TW (1) TW200944522A (es)
WO (1) WO2009123855A1 (es)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4075001A (en) 1976-06-18 1978-02-21 Fmc Corporation 3-Aminoisothiazole derivatives as herbicides
IL72091A0 (en) 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-aryl 5-isothiazolyl)urea derivatives
DE4328425A1 (de) 1993-08-24 1995-03-02 Basf Ag Acylamino-substituierte Isoxazol- bzw. Isothiazolderivate, Verfahren zu deren Herstellung und ihre Verwendung
JP4632541B2 (ja) 1998-10-23 2011-02-16 ダウ・アグロサイエンス・エル・エル・シー ３−（置換フェニル）−５−（置換ヘテロシクリル）−１，２，４−トリアゾール化合物
ATE304009T1 (de) 2001-04-04 2005-09-15 Pfizer Prod Inc Neue benzotriazole mit entzündungshemmender wirkung
AU2004228057A1 (en) * 2003-04-03 2004-10-21 Merck & Co., Inc. Di-aryl substituted pyrazole modulators of metabotropic glutamate receptor-5
TW200735866A (en) * 2005-11-18 2007-10-01 Synta Pharmaceuticals Corp Compounds for the treatment of proliferative disorders
UA95480C2 (uk) 2006-06-08 2011-08-10 Елі Ліллі Енд Компані Заміщені карбоксаміди
JO2686B1 (en) * 2007-04-19 2013-03-03 جلاكسو جروب ليمتد Vehicles

Also Published As

Publication number Publication date
EP2276759B1 (en) 2011-10-19
CL2009000646A1 (es) 2010-04-09
TW200944522A (en) 2009-11-01
HRP20110784T1 (hr) 2011-11-30
AU2009232263A1 (en) 2009-10-08
AR070986A1 (es) 2010-05-19
US20090253750A1 (en) 2009-10-08
PL2276759T3 (pl) 2012-03-30
DK2276759T3 (da) 2012-01-02
CN101959883A (zh) 2011-01-26
AU2009232263B2 (en) 2013-07-04
KR20100118999A (ko) 2010-11-08
EA201071168A1 (ru) 2011-04-29
CN101959883B (zh) 2013-01-30
JP2011516481A (ja) 2011-05-26
KR101247010B1 (ko) 2013-03-26
ATE529422T1 (de) 2011-11-15
EP2276759A1 (en) 2011-01-26
PT2276759E (pt) 2011-12-19
EA018001B1 (ru) 2013-04-30
JO2775B1 (en) 2014-03-15
US7932274B2 (en) 2011-04-26
CY1112118T1 (el) 2015-11-04
CA2720631A1 (en) 2009-10-08
BRPI0910692A2 (pt) 2018-03-27
JP5449320B2 (ja) 2014-03-19
MX2010010781A (es) 2010-12-14
WO2009123855A1 (en) 2009-10-08
SI2276759T1 (sl) 2012-02-29
CA2720631C (en) 2012-08-28
ES2372677T3 (es) 2012-01-25

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed