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PE20091458A1 - Compuestos heterociclicos antiviricos - Google Patents

Compuestos heterociclicos antiviricos

Info

Publication number
PE20091458A1
PE20091458A1 PE2009000213A PE2009000213A PE20091458A1 PE 20091458 A1 PE20091458 A1 PE 20091458A1 PE 2009000213 A PE2009000213 A PE 2009000213A PE 2009000213 A PE2009000213 A PE 2009000213A PE 20091458 A1 PE20091458 A1 PE 20091458A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
methanosulfonyl
cycloalkyl
hydroxy
Prior art date
Application number
PE2009000213A
Other languages
English (en)
Inventor
Sharada Shenvi Lavadie
Clara Jeou Jen Lin
Francisco Javier Talamas
Robert James Weikert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40521706&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091458(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20091458A1 publication Critical patent/PE20091458A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

REFERIDA A UN COMPUESTO BENZOFURANO DE FORMULA (I), DONDE A1 ES FENILENO O PIRIDINILENO; A2 ES FENILO O PIRIDINILO OPCIONALMENTE SUSTITUIDOS POR HALO, CN, ALQUILO C1-C6, ENTRE OTROS; R1 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C7, ENTRE OTROS; Y ES NR2R3, HIDROXIALQUILO C1-C6, ACILO C1-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C10, CICLOALQUILO C3-C6, ENTRE OTROS; R3 ES H, ALQUILO C1-C10, ACILO C1-C6, ENTRE OTROS; X2 ES NHR5 U O; R5 ES H, ALQUILO C1-C6 O CICLOALQUILO C3-C7. SON COMPUESTOS PREFERIDOS: METILAMIDA DEL ACIDO 6-[(2-HIDROXI-ETIL)-METANOSULFONIL-AMINO]-5-METOXI-2-(4-FENILAMINO-FENIL)-BENZOFURANO-3-CARBOXILICO, METILAMIDA DEL ACIDO 2-[4-(4-FLUOR-FENILAMINO)-FENIL]-6-[(2-HIDROXI-ETIL)-METANOSULFONIL-AMINO]-5-METOXI-BENZOFURANO-3-CARBOXILICO, METILAMIDA DEL ACIDO 2-[4-(4-CLORO-FENILAMINO)-FENIL]-6-[(2-HIDROXI-ETIL)-METANOSULFONIL-AMINO]-5-METOXI-BENZOFURANO-3-CARBOXILICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE POLIMERASA VIRICA DE RNA DEPENDIENTE DE RNA Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDAD CAUSADA POR EL VIRUS DE LA HEPATITIS C (HCV)
PE2009000213A 2008-02-14 2009-02-13 Compuestos heterociclicos antiviricos PE20091458A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2862908P 2008-02-14 2008-02-14
US13860308P 2008-12-18 2008-12-18

Publications (1)

Publication Number Publication Date
PE20091458A1 true PE20091458A1 (es) 2009-09-24

Family

ID=40521706

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000213A PE20091458A1 (es) 2008-02-14 2009-02-13 Compuestos heterociclicos antiviricos

Country Status (18)

Country Link
US (1) US8071797B2 (es)
EP (1) EP2245023B1 (es)
JP (1) JP2011512341A (es)
KR (1) KR20100117073A (es)
CN (1) CN101910145A (es)
AR (1) AR070361A1 (es)
AT (1) ATE539070T1 (es)
AU (1) AU2009214194B2 (es)
BR (1) BRPI0907885A2 (es)
CA (1) CA2714254A1 (es)
CL (1) CL2009000305A1 (es)
ES (1) ES2377280T3 (es)
IL (1) IL204736A0 (es)
MX (1) MX2010004623A (es)
PE (1) PE20091458A1 (es)
RU (1) RU2010137635A (es)
TW (1) TW200936573A (es)
WO (1) WO2009101022A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8198449B2 (en) 2008-09-11 2012-06-12 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US7994171B2 (en) 2008-09-11 2011-08-09 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8048887B2 (en) * 2008-09-11 2011-11-01 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8293909B2 (en) 2008-09-11 2012-10-23 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
MX2012002958A (es) * 2009-09-24 2012-04-19 Hoffmann La Roche Compuestos antivirales heterociclicos.
US8324212B2 (en) 2010-02-25 2012-12-04 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
WO2011112191A1 (en) * 2010-03-11 2011-09-15 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis c
US8354410B2 (en) 2010-03-11 2013-01-15 Bristol-Meyers Squibb Company Compounds for the treatment of hepatitis C
AR082453A1 (es) * 2010-04-21 2012-12-12 Novartis Ag Compuestos de furopiridina, composiciones farmaceuticas que los contienen y usos de los mismos
US8445497B2 (en) * 2010-06-30 2013-05-21 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US20130302282A1 (en) 2010-10-26 2013-11-14 Presidio Pharmaceuticals, Inc. Inhibitors of Hepatitis C Virus
US8507683B2 (en) 2010-12-09 2013-08-13 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
WO2012087833A1 (en) 2010-12-22 2012-06-28 Abbott Laboratories Hepatitis c inhibitors and uses thereof
SG10201606646RA (en) * 2011-08-17 2016-09-29 Glaxosmithkline Llc Therapeutic methods
MX354676B (es) 2011-08-19 2018-03-15 Glaxo Group Ltd Compuestos de benzofurano para el tratamiento de infecciones por el virus de hepatitis c (hcv).
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
US9303020B2 (en) 2012-02-08 2016-04-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
EP2831066B1 (en) 2012-03-27 2016-10-05 Bristol-Myers Squibb Company Benzofuran derivatives for the treatment of hepatitis c
JP2016505011A (ja) 2013-01-10 2016-02-18 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎の治療用の大環状ベンゾフランおよびアザベンゾフラン化合物
US8962651B2 (en) 2013-03-13 2015-02-24 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US9738653B2 (en) 2013-03-14 2017-08-22 Bristol-Myers Squibb Company Fused furans for the treatment of hepatitis C
ES2688147T3 (es) 2014-03-21 2018-10-31 Bristol-Myers Squibb Company Compuestos de 6H-furo[2,3-e]indol para el tratamiento de la hepatitis C
KR20160126085A (ko) 2014-03-21 2016-11-01 브리스톨-마이어스 스큅 컴퍼니 C형 간염의 치료를 위한 시아노 함유 아자벤조푸란 화합물
WO2015143256A1 (en) * 2014-03-21 2015-09-24 Bristol-Myers Squibb Company Cyanoamino (aza)benzofuran compounds for the treatment of hepatitis c
ES2689278T3 (es) 2014-05-21 2018-11-13 Bristol-Myers Squibb Company Compuestos de 2-(aril o heteroaril)fenilo (aza)benzofurano para el tratamiento de la hepatitis C
EP3154963A1 (en) 2014-06-11 2017-04-19 Bristol-Myers Squibb Company Substituted 2-phenyl (aza)benzofuran compounds for the treatment of hepatitis c
EP3180346A1 (en) 2014-08-05 2017-06-21 Bristol-Myers Squibb Company Furopyridine compounds for the treatment of hepatitis c
EP3199530A4 (en) 2014-09-26 2017-10-04 Changzhou Yinsheng Pharmaceutical Co., Ltd. Benzofuran analogue as ns4b inhibitor
WO2016054299A1 (en) 2014-10-02 2016-04-07 Bristol-Myers Squibb Company Macrocyclic benzofuran compounds for the treatment of hepatitis c
US10131645B2 (en) 2015-02-19 2018-11-20 Bristol-Myers Squibb Company Benzofurans substituted with primary benzamide as HCV inhibitors
US10125111B2 (en) 2015-02-19 2018-11-13 Bristol-Myers Squibb Company Benzofuran compounds for the treatment of hepatitis C
US10087167B2 (en) 2015-02-19 2018-10-02 Bristol-Myers Squibb Company Benzofurans substituted with secondary benzamide as HCV inhibitors
WO2016133972A1 (en) 2015-02-19 2016-08-25 Bristol-Myers Squibb Company Substituted benzofuran compounds for the treatment of hepatitis c
WO2016133961A1 (en) 2015-02-19 2016-08-25 Bristol-Myers Squibb Company Benzofurans substituted with bicyclic secondary benzamide as hcv inhibitors
TWI731854B (zh) 2015-03-23 2021-07-01 美商共結晶製藥公司 Ｃ型肝炎病毒聚合酶之抑制劑
CN105732602B (zh) * 2015-09-23 2017-04-19 常州寅盛药业有限公司 作为ns4b抑制剂的苯并呋喃类似物
US10759787B2 (en) * 2015-11-19 2020-09-01 Jiangsu Hengrui Medicine Co., Ltd. Benzofuran derivative, preparation method thereof and use thereof in medicine
RU2771234C2 (ru) 2015-11-24 2022-04-28 Л'Ореаль Композиции для обработки волос

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1731993A (zh) * 2002-11-01 2006-02-08 维洛药品公司 苯并呋喃化合物、组合物以及治疗和预防丙型肝炎病毒感染及相关疾病的方法
CL2007000361A1 (es) 2006-02-09 2008-01-25 Wyeth Corp Combinacion que comprende un inhibidor de la arn polimerasa del virus de la hepatitis c (vhc) y un inhibidor de la proteasa del vhc; composicion farmaceutica que la comprende; y uso de la combinacion para tratar trastornos asociados con vhc.
US20090047246A1 (en) * 2007-02-12 2009-02-19 Intermune, Inc. Novel inhibitors of hepatitis c virus replication

Also Published As

Publication number Publication date
AU2009214194B2 (en) 2012-05-17
MX2010004623A (es) 2010-06-07
RU2010137635A (ru) 2012-03-20
CL2009000305A1 (es) 2010-02-19
IL204736A0 (en) 2010-11-30
TW200936573A (en) 2009-09-01
JP2011512341A (ja) 2011-04-21
KR20100117073A (ko) 2010-11-02
ES2377280T3 (es) 2012-03-26
EP2245023A1 (en) 2010-11-03
CN101910145A (zh) 2010-12-08
BRPI0907885A2 (pt) 2015-07-21
US8071797B2 (en) 2011-12-06
AR070361A1 (es) 2010-03-31
ATE539070T1 (de) 2012-01-15
EP2245023B1 (en) 2011-12-28
US20090208449A1 (en) 2009-08-20
AU2009214194A1 (en) 2009-08-20
WO2009101022A1 (en) 2009-08-20
CA2714254A1 (en) 2009-08-20

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