PE20090305A1 - Proceso mejorado para la elaboracion de hidrazidas - Google Patents
Proceso mejorado para la elaboracion de hidrazidasInfo
- Publication number
- PE20090305A1 PE20090305A1 PE2008000869A PE2008000869A PE20090305A1 PE 20090305 A1 PE20090305 A1 PE 20090305A1 PE 2008000869 A PE2008000869 A PE 2008000869A PE 2008000869 A PE2008000869 A PE 2008000869A PE 20090305 A1 PE20090305 A1 PE 20090305A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- inert solvent
- procedure
- hydrazide
- hydrazine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 229940042795 hydrazides for tuberculosis treatment Drugs 0.000 title 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 6
- 239000012442 inert solvent Substances 0.000 abstract 4
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- SRNHFGGOWAGEPZ-UHFFFAOYSA-N 3-methyl-3-sulfanylbutanehydrazide Chemical compound CC(C)(S)CC(=O)NN SRNHFGGOWAGEPZ-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 150000001263 acyl chlorides Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940127121 immunoconjugate Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/48—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C241/04—Preparation of hydrazides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/24—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
- C07C243/26—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C243/28—Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Coating Apparatus (AREA)
Abstract
SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UNA HIDRAZIDA DE FORMULA (I) A PARTIR DE UNA HIDRAZINA Y UN CLORURO DE ACILO QUE COMPRENDE: A) PREPARAR UNA SUSPENSION AGITADA UNIFORME QUE CONTIENE HIDRAZINA Y UN DISOLVENTE INERTE TAL COMO CLORURO DE METILENO QUE COMPRENDE a) ENFRIAR UN DISOLVENTE INERTE A UNA TEMPERATURA DE -68 ºC A -75 ºC, Y b) AGREGAR HIDRAZINA DISUELTA EN UN DISOLVENTE INERTE EN FORMA DE GOTA AL DISOLVENTE INERTE FRIO; B) AGREGAR UN CLORURO DE ACILO QUE COMPRENDE UN BENCILTIOETER DE FORMULA (i) CONTINUAMENTE A DICHA SUSPENSION. DICHO PROCEDIMIENTO PERMITE LA FORMACION DE UN SUB-PRODUCTO DE BIS-HIDRAZIDA DE FORMULA (ii) EN UNA CANTIDAD MENOR AL 5%. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE LA HIDRAZIDA DE ACIDO 3-METIL-3-MERCAPTOBUTANOICO A PARTIR DEL COMPUESTO DE FORMULA (I) EL CUAL ES UTIL COMO LIGADOR EN EL INMUNOCONJUGADO GEMTUZUMAB-OZOGAMICINA O INOTUZUMAB-OZOGAMICINA
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93952907P | 2007-05-22 | 2007-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090305A1 true PE20090305A1 (es) | 2009-03-15 |
Family
ID=39810161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000869A PE20090305A1 (es) | 2007-05-22 | 2008-05-20 | Proceso mejorado para la elaboracion de hidrazidas |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US8110705B2 (es) |
| EP (2) | EP2155258B1 (es) |
| JP (4) | JP5697446B2 (es) |
| KR (1) | KR101547705B1 (es) |
| CN (2) | CN102558001B (es) |
| AR (1) | AR066674A1 (es) |
| AU (1) | AU2008256905B2 (es) |
| BR (1) | BRPI0811140B1 (es) |
| CA (1) | CA2687852A1 (es) |
| CL (1) | CL2008001490A1 (es) |
| CY (2) | CY1119373T1 (es) |
| DK (2) | DK2465541T3 (es) |
| ES (2) | ES2686019T3 (es) |
| HU (2) | HUE036704T2 (es) |
| IL (1) | IL202242A (es) |
| MX (1) | MX2009012587A (es) |
| PA (1) | PA8781201A1 (es) |
| PE (1) | PE20090305A1 (es) |
| PL (2) | PL2155258T3 (es) |
| PT (2) | PT2155258T (es) |
| SI (2) | SI2465541T1 (es) |
| TW (1) | TW200904784A (es) |
| WO (1) | WO2008147765A1 (es) |
| ZA (1) | ZA200908229B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2465541T3 (en) * | 2007-05-22 | 2018-09-17 | Wyeth Llc | improved methods for producing hydrazides |
| CA2929283C (en) | 2013-11-04 | 2022-07-19 | Pfizer Inc. | Intermediates and methods for synthesizing calicheamicin derivatives |
| PE20161413A1 (es) | 2013-11-04 | 2017-01-10 | Stemcentrx Inc | Conjugados de anticuerpo anti-efna4-farmaco |
| SG11201608953WA (en) | 2014-04-30 | 2016-11-29 | Pfizer | Anti-ptk7 antibody-drug conjugates |
| WO2016105330A1 (en) * | 2014-12-22 | 2016-06-30 | Hewlett Packard Enterprise Development Lp | Response to an inoperative network device managed by a controller |
| US20190048073A1 (en) | 2017-07-20 | 2019-02-14 | Pfizer Inc. | Anti-gd3 antibodies and antibody-drug conjugates |
| JP7489054B2 (ja) | 2017-10-03 | 2024-05-23 | 公立大学法人大阪 | 細胞の取得方法、および細胞の培養方法 |
| CN109574870A (zh) * | 2018-12-25 | 2019-04-05 | 维思普新材料（苏州）有限公司 | 一种酰肼的连续制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US623230A (en) * | 1899-04-18 | Rotary ore-cooler | ||
| US4291022A (en) | 1975-03-11 | 1981-09-22 | Sandoz Ltd. | Organic compounds |
| DE2608336A1 (de) | 1975-03-11 | 1976-09-30 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| US4479953A (en) | 1983-08-25 | 1984-10-30 | Merck & Co., Inc. | Pyrazine aldimine compounds as antimicrobial agents |
| US4970198A (en) | 1985-10-17 | 1990-11-13 | American Cyanamid Company | Antitumor antibiotics (LL-E33288 complex) |
| US4729781A (en) | 1986-08-04 | 1988-03-08 | Sandoz Ltd. | 3,6-dichloro-2-methoxybenzohydroxamic acid derivatives and use as herbicidal agents |
| DE3771413D1 (de) | 1986-08-04 | 1991-08-22 | Sandoz Ag | Benzhydroxamsaeure-derivate. |
| US4939244A (en) | 1987-01-30 | 1990-07-03 | American Cyanamid Company | Pseudoaglycones of LL-E33288 antibiotics |
| US5079233A (en) | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
| US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
| US5053394A (en) * | 1988-09-21 | 1991-10-01 | American Cyanamid Company | Targeted forms of methyltrithio antitumor agents |
| JPH05222044A (ja) * | 1991-10-25 | 1993-08-31 | Eastman Kodak Co | ２当量ピラゾロトリアゾールマゼンタカプラーの製造 |
| RO112860B1 (ro) * | 1991-11-22 | 1998-01-30 | Uniroyal Chem Co Inc | Derivati de fenilhidrazina, compozitie pesticida si metoda pentru controlul pestelor |
| US5690904A (en) * | 1993-07-12 | 1997-11-25 | Amersham International Plc | Diagnostic radiopharmaceutical compounds (That) |
| US5443953A (en) | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
| US5403015A (en) * | 1993-12-09 | 1995-04-04 | Forte; Steven L. | Cards and methods for playing casino 21 or blackjack |
| AU3264695A (en) | 1994-08-23 | 1996-03-14 | Nissan Chemical Industries Ltd. | Pyridine derivative |
| IT1292092B1 (it) | 1997-06-05 | 1999-01-25 | Geange Ltd | Impiego di derivati eterociclici aromatici azotati nel trattamento topico di affezioni di tessuti epiteliali |
| WO2000023449A1 (en) | 1998-10-16 | 2000-04-27 | Merck Sharp & Dohme Limited | Pyrazolo-triazine derivatives as ligands for gaba receptors |
| GB0008696D0 (en) | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic agents |
| EP1406632A4 (en) | 2001-06-08 | 2009-11-04 | Cytovia Inc | SUBSTITUTED 3-ARYL-5-ARYL-1,2,4-OXADIAZOLE AND ANALOGUE AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCTORS AND THEIR USE |
| PT2371392E (pt) * | 2002-05-02 | 2015-10-07 | Wyeth Holdings Llc | Conjugados de derivado da caliqueamicina - transportador |
| US6803379B2 (en) | 2002-06-04 | 2004-10-12 | Jose A. Fernandez-Pol | Pharmacological agents and methods of treatment that inactivate pathogenic prokaryotic and eukaryotic cells and viruses by attacking highly conserved domains in structural metalloprotein and metalloenzyme targets |
| EP1581213A4 (en) | 2002-12-18 | 2008-11-19 | Cytovia Inc | 3,5-DISUBSTITUTED 1,2,4-OXADIAZOLE AND ANALOGUE TO ACTIVATE CASPASE AND INTRODUCTION OF APOPTOSIS AND THEIR USE |
| CA2509413C (en) | 2002-12-20 | 2012-05-01 | Glaxo Group Limited | Benzazepine derivatives for the treatment of neurological disorders |
| US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
| JP2006528694A (ja) | 2003-05-13 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | ナフチリジンインテグラーゼインヒビター |
| CA2529622A1 (en) | 2003-07-02 | 2005-01-20 | Sugen, Inc. | Indolinone hydrazides as c-met inhibitors |
| MXPA06000051A (es) | 2003-07-02 | 2006-03-21 | Vertex Pharma | Pirimidinas utiles como moduladores de canales ionicos dependientes de voltaje. |
| SE0302486D0 (sv) | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
| WO2005097119A2 (en) * | 2004-04-06 | 2005-10-20 | Semafore Pharmaceuticals, Inc. | Pten inhibitors |
| AR052774A1 (es) * | 2004-10-08 | 2007-04-04 | Wyeth Corp | Inmunoterapia para trastornos autoinmunes |
| TWI404706B (zh) * | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
| DK2465541T3 (en) * | 2007-05-22 | 2018-09-17 | Wyeth Llc | improved methods for producing hydrazides |
-
2008
- 2008-05-20 DK DK12159159.8T patent/DK2465541T3/en active
- 2008-05-20 HU HUE08755945A patent/HUE036704T2/hu unknown
- 2008-05-20 SI SI200831994T patent/SI2465541T1/sl unknown
- 2008-05-20 DK DK08755945.6T patent/DK2155258T3/en active
- 2008-05-20 PT PT87559456T patent/PT2155258T/pt unknown
- 2008-05-20 KR KR1020097026806A patent/KR101547705B1/ko active Active
- 2008-05-20 HU HUE12159159A patent/HUE039657T2/hu unknown
- 2008-05-20 PL PL08755945T patent/PL2155258T3/pl unknown
- 2008-05-20 US US12/123,777 patent/US8110705B2/en active Active
- 2008-05-20 SI SI200831859T patent/SI2155258T1/sl unknown
- 2008-05-20 ES ES12159159.8T patent/ES2686019T3/es active Active
- 2008-05-20 BR BRPI0811140-5A patent/BRPI0811140B1/pt active IP Right Grant
- 2008-05-20 EP EP08755945.6A patent/EP2155258B1/en active Active
- 2008-05-20 AU AU2008256905A patent/AU2008256905B2/en active Active
- 2008-05-20 CN CN201110434577.XA patent/CN102558001B/zh active Active
- 2008-05-20 CA CA2687852A patent/CA2687852A1/en not_active Abandoned
- 2008-05-20 MX MX2009012587A patent/MX2009012587A/es active IP Right Grant
- 2008-05-20 PT PT12159159T patent/PT2465541T/pt unknown
- 2008-05-20 JP JP2010509499A patent/JP5697446B2/ja active Active
- 2008-05-20 PE PE2008000869A patent/PE20090305A1/es not_active Application Discontinuation
- 2008-05-20 CN CN2008800216526A patent/CN101835494B/zh active Active
- 2008-05-20 PL PL12159159T patent/PL2465541T3/pl unknown
- 2008-05-20 EP EP12159159.8A patent/EP2465541B1/en active Active
- 2008-05-20 WO PCT/US2008/064213 patent/WO2008147765A1/en not_active Ceased
- 2008-05-20 ES ES08755945.6T patent/ES2642888T3/es active Active
- 2008-05-22 TW TW097118930A patent/TW200904784A/zh unknown
- 2008-05-22 PA PA20088781201A patent/PA8781201A1/es unknown
- 2008-05-22 AR ARP080102165A patent/AR066674A1/es unknown
- 2008-05-22 CL CL200801490A patent/CL2008001490A1/es unknown
-
2009
- 2009-11-19 IL IL202242A patent/IL202242A/en active IP Right Grant
- 2009-11-20 ZA ZA200908229A patent/ZA200908229B/xx unknown
-
2012
- 2012-01-27 US US13/360,220 patent/US8383857B2/en active Active
-
2013
- 2013-01-31 US US13/755,886 patent/US8853451B2/en active Active
- 2013-08-23 JP JP2013172956A patent/JP2013234203A/ja not_active Withdrawn
-
2014
- 2014-10-02 US US14/504,738 patent/US9227924B2/en active Active
-
2015
- 2015-11-06 JP JP2015218118A patent/JP2016026219A/ja not_active Withdrawn
- 2015-12-18 US US14/973,869 patent/US9738602B2/en active Active
-
2017
- 2017-08-03 JP JP2017150482A patent/JP2017193584A/ja active Pending
- 2017-09-20 CY CY20171100991T patent/CY1119373T1/el unknown
-
2018
- 2018-08-13 CY CY181100854T patent/CY1120592T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| FX | Voluntary withdrawal |