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PE20090297A1 - Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogenesis - Google Patents

Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogenesis

Info

Publication number
PE20090297A1
PE20090297A1 PE2008000823A PE2008000823A PE20090297A1 PE 20090297 A1 PE20090297 A1 PE 20090297A1 PE 2008000823 A PE2008000823 A PE 2008000823A PE 2008000823 A PE2008000823 A PE 2008000823A PE 20090297 A1 PE20090297 A1 PE 20090297A1
Authority
PE
Peru
Prior art keywords
heteroaryl
pirazole
angiogenesis
substituted
halogen
Prior art date
Application number
PE2008000823A
Other languages
English (en)
Inventor
Stephen Boyer
Michael Hater
Philip Wickens
Manoj Patel
Ellalahewage Sathyajith Kumarasinghe
Ajay Kumar Bhargava
Karl-Heinz Thierauch
Hartmut Beck
Susanne Greschat
Peter Ellinghaus
Patrick Paulus
Holger Hess-Stumpp
Original Assignee
Bayer Healthcare Ag
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Bayer Schering Pharma Ag filed Critical Bayer Healthcare Ag
Publication of PE20090297A1 publication Critical patent/PE20090297A1/es

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

REFERIDA A UN DERIVADO DE PIRAZOL DE FORMULA (I), DONDE A ES UN HETEROCICLILO O UN HETEROARILO OPCIONALMENTE SUSTITUIDO CON HALOGENO O FENILO; n ES UN ENTERO DE 0 A 3; R1 ES HALOGENO, C(O)R6, OC(O)R6, SR6, ENTRE OTROS; R2 ES H, HALOGENO, CIANO, H, ENTRE OTROS; R3 Y R4 SON H, HALOGENO, OR6, SR6, ENTRE OTROS; R6 ES H, ARILO, HETEROARILO, ENTRE OTROS; R5 ES H, OXO, ALQUILO, ENTRE OTROS; SON COMPUESTOS PREFERIDOS: 5-[5-METIL-1-(4-METILBENCIL)-1H-PIRAZOL-3-IL]-3-[4-(TRIFLUOROMETOXI)FENIL]-1,2,4-OXADIAZOL, 3-{4-[(4-CLOROBENCIL)OXI]FENIL}-5-[5-METIL-1-(4-METILBENCIL)-1H-PIRAZOL-3-IL]-1,2,4-OXADIAZOL, 3-(4-BROMOFENIL)-5-[5-METIL-1-(4-METILBENCIL)-1H-PIRAZOL-3-IL]-1,2,4-OXADIAZOL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS HIPERPROLIFERATIVOS Y/O DE ANGIOGENESIS
PE2008000823A 2007-05-18 2008-05-12 Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogenesis PE20090297A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US93081607P 2007-05-18 2007-05-18

Publications (1)

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PE20090297A1 true PE20090297A1 (es) 2009-03-27

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PE2008000823A PE20090297A1 (es) 2007-05-18 2008-05-12 Derivados de pirazol sustituidos con heteroarilo utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogenesis

Country Status (19)

Country Link
US (1) US8796253B2 (es)
EP (1) EP2148877A2 (es)
JP (1) JP5702138B2 (es)
KR (1) KR20100016617A (es)
CN (1) CN101765596B (es)
AR (1) AR066617A1 (es)
AU (1) AU2008253311A1 (es)
BR (1) BRPI0812361A2 (es)
CA (1) CA2687306A1 (es)
CL (1) CL2008001372A1 (es)
IL (1) IL201537A0 (es)
MX (1) MX2009012000A (es)
PA (1) PA8780201A1 (es)
PE (1) PE20090297A1 (es)
RU (1) RU2009146851A (es)
TW (1) TW200909428A (es)
UY (1) UY31080A1 (es)
WO (1) WO2008141731A2 (es)
ZA (1) ZA200907999B (es)

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CN101765596B (zh) 2015-04-29
CL2008001372A1 (es) 2008-12-05
EP2148877A2 (en) 2010-02-03
IL201537A0 (en) 2010-05-31
BRPI0812361A2 (pt) 2015-02-03
UY31080A1 (es) 2009-01-05
US8796253B2 (en) 2014-08-05
AU2008253311A1 (en) 2008-11-27
CA2687306A1 (en) 2008-11-27
MX2009012000A (es) 2009-11-19
AR066617A1 (es) 2009-09-02
ZA200907999B (en) 2011-06-29
RU2009146851A (ru) 2011-06-27
CN101765596A (zh) 2010-06-30
TW200909428A (en) 2009-03-01
US20100249085A1 (en) 2010-09-30
JP5702138B2 (ja) 2015-04-15
WO2008141731A2 (en) 2008-11-27
PA8780201A1 (es) 2009-02-09
KR20100016617A (ko) 2010-02-12
WO2008141731A3 (en) 2009-03-26

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