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PE20090157A1 - Derivados de pirimidinona como moduladores del receptor acoplado a proteina g 119 (gpr119) - Google Patents

Derivados de pirimidinona como moduladores del receptor acoplado a proteina g 119 (gpr119)

Info

Publication number
PE20090157A1
PE20090157A1 PE2008000679A PE2008000679A PE20090157A1 PE 20090157 A1 PE20090157 A1 PE 20090157A1 PE 2008000679 A PE2008000679 A PE 2008000679A PE 2008000679 A PE2008000679 A PE 2008000679A PE 20090157 A1 PE20090157 A1 PE 20090157A1
Authority
PE
Peru
Prior art keywords
alkyl
gpr119
modulators
protein
aryl
Prior art date
Application number
PE2008000679A
Other languages
English (en)
Inventor
Craig D Boyle
Samuel Chackalamannil
Claire M Lankin
Unmesh G Shah
Hong Liu
Andrew W Stamford
Bernard R Neustadt
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20090157A1 publication Critical patent/PE20090157A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE PIRIMIDINONA DE FORMULA (I) DONDE R ESTA AUSENTE O ES O; R1 ES H, ALQUILO(C1-C12), HALOALQUILO(C1-C12), C(O)-ARILO(C6-C14), ENTRE OTROS; R2 ES ALQUILO(C1-C12), HALOALQUILO(C1-C12), C(O)-ALQUILO(C1-C12), ALQUILEN(C1-C12)-O-ARILO(C6-C14), ENTRE OTROS; R3 ES ALQUILO(C1-C12), C(O)-ARILO(C6-C14), C(O)-ALQUILO(C1-C12), ENTRE OTROS; R4 ES H, ALQUILO(C1-C12), ALQUILEN(C1-C12)-O-ALQUILO(C1-C12), ALQUILEN(C1-C12)-O-ARILO(C6-C14), ENTRE OTROS; R10 ES H, ALQUILO(C1-C12), HETEROARILO DE 5 A 14 MIEMBROS, CICLOALQUILO(C3-C10), ENTRE OTROS; R11 ES H, ALQUILO(C1-C12), CICLOALQUILO(C3-C10), ENTRE OTROS; R12 ES H, ALQUILO(C1-C12), HETEROCICLOALQUILO DE 3 A 10 MIEMBROS, ALCOXI(C1-C12), ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS COMPUESTOS DE FORMULA (i), (ii), (iii), ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR ACOPLADO A PROTEINA G 119 (GPR119) SIENDO UTILES EN EL TRATAMIENTO DE DIABETES TIPO 1 Y 2, OBESIDAD, SINDROME METABOLICO
PE2008000679A 2007-04-20 2008-04-18 Derivados de pirimidinona como moduladores del receptor acoplado a proteina g 119 (gpr119) PE20090157A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92546507P 2007-04-20 2007-04-20
US95332307P 2007-08-01 2007-08-01

Publications (1)

Publication Number Publication Date
PE20090157A1 true PE20090157A1 (es) 2009-03-27

Family

ID=39651245

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000679A PE20090157A1 (es) 2007-04-20 2008-04-18 Derivados de pirimidinona como moduladores del receptor acoplado a proteina g 119 (gpr119)

Country Status (11)

Country Link
US (1) US8318751B2 (es)
EP (1) EP2148870A1 (es)
JP (1) JP2010524941A (es)
CN (1) CN101754961A (es)
AR (1) AR066120A1 (es)
CA (1) CA2684634A1 (es)
CL (1) CL2008001125A1 (es)
MX (1) MX2009011359A (es)
PE (1) PE20090157A1 (es)
TW (1) TW200845996A (es)
WO (1) WO2008130584A1 (es)

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US20110065671A1 (en) * 2008-05-19 2011-03-17 Harris Joel M Bicyclic heterocycle derivatives and use thereof as gpr119 modulators
CA2730593A1 (en) 2008-07-16 2010-01-21 Schering Corporation Bicyclic heterocycle derivatives and use thereof as gpr119 modulators
CA2730606A1 (en) 2008-07-16 2010-01-21 Schering Corporation Bicyclic heterocycle derivatives and methods of use thereof
AR076928A1 (es) * 2009-05-28 2011-07-20 Otsuka Pharma Co Ltd Derivados de 3h-pirido[4, 3-d]pirimidin-4-ona, un metodo para su preparacion, composiciones farmaceuticas que los comprenden y su uso en la manufactura de un medicamento para el tratamiento o prevencion de enfermedades relacionadas con el estres.
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
JP2013522279A (ja) 2010-03-18 2013-06-13 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及び関連状態の治療で用いるｇｐｒ１１９作動薬とｄｄｐ−ｉｖ阻害薬リナグリプチンの組合せ
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
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US11091477B2 (en) * 2016-08-12 2021-08-17 Madera Therapeutics, LLC Protein kinase regulators
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Also Published As

Publication number Publication date
EP2148870A1 (en) 2010-02-03
AR066120A1 (es) 2009-07-22
US20100113487A1 (en) 2010-05-06
CN101754961A (zh) 2010-06-23
MX2009011359A (es) 2009-11-05
CL2008001125A1 (es) 2008-10-24
CA2684634A1 (en) 2008-10-30
US8318751B2 (en) 2012-11-27
TW200845996A (en) 2008-12-01
JP2010524941A (ja) 2010-07-22
WO2008130584A1 (en) 2008-10-30

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