PE20090111A1 - Derivados de bencimidazol - Google Patents
Derivados de bencimidazolInfo
- Publication number
- PE20090111A1 PE20090111A1 PE2008000405A PE2008000405A PE20090111A1 PE 20090111 A1 PE20090111 A1 PE 20090111A1 PE 2008000405 A PE2008000405 A PE 2008000405A PE 2008000405 A PE2008000405 A PE 2008000405A PE 20090111 A1 PE20090111 A1 PE 20090111A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- integer
- alcoxy
- link
- halo
- Prior art date
Links
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 230000006866 deterioration Effects 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
REFERIDA A UN DERIVADO DE BENCIMIDAZOL DE FORMULA (I), DONDE LA LINEA PUNTEADA REPRESENTA UN ENLACE OPCIONAL Y ADICIONAL; M1 C(R3); X ES UN ENLACE O ALQUILENO C1-C6; Y ES C(O), C(S), (CH2)q, C(O)NR4, SO2, ENTRE OTROS; Z ES UN ENLACE, ALQUILENO C1-C6, C(O), CH(CN), ENTRE OTROS; R1 ES UN GRUPO a), b), c), ENTRE OTROS; Q ES N(R8), S, O; R ES H, OH, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; R2 ES UN ANILLO HETEROARILO DE SEIS MIEMBROS QUE TIENE 1 O 2 HETEROATOMOS SELECCIONADOS DE N O N-O, UN ANILLO HETEROARILO DE CINCO MIEMBROS QUE TIENE DE 1 A 3 HETEROATOMOS SELECCIONADOS DE N, O, S, TETRAHIDROISOQUINOLINA, ENTRE OTROS; R3 ES H, HALO, ALQUILO C1-C6, OH, ALCOXI C1-C6; R4 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; R5 ES H, ALQUILO C1-C6, C(O)R20, C(O)2R20, ENTRE OTROS; R8 ES H, ALQUILO C1-C6, HALOALQUILO C1-C6, ENTRE OTROS; R12 ES ALQUILO C1-C6, OH, ALCOXI C1-C6, ENTRE OTROS; R13 ES ALQUILO C1-C6, OH, ALCOXI C1-C6, F; R25 ES ALQUILO C1-C6, CF3, OH, HALO, ENTRE OTROS; R20 ES H, ALQUILO C1-C6, ENTRE OTROS; a Y b SON UN ENTERO DE 0 A 2; k ES UN ENTERO DE 0A 4; k1 ES UN ENTERO DE 0 A 3; n ES 2; p ES UN ENTERO DE 1 A 3; q ES UN ENTERO DE 1 A 5; r ES UN ENTERO DE 0 A 3. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE LA DIABETES, DETERIORO DE LA TOLERANCIA A GLUCOSA O DETERIORO DE GLUCOSA EN AYUNAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90445307P | 2007-03-02 | 2007-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090111A1 true PE20090111A1 (es) | 2009-02-26 |
Family
ID=39386454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000405A PE20090111A1 (es) | 2007-03-02 | 2008-02-28 | Derivados de bencimidazol |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20100144591A1 (es) |
| EP (1) | EP2114402A2 (es) |
| JP (1) | JP2010520201A (es) |
| KR (1) | KR20090127902A (es) |
| CN (1) | CN101674827A (es) |
| AR (1) | AR065495A1 (es) |
| AU (1) | AU2008223513A1 (es) |
| BR (1) | BRPI0808707A2 (es) |
| CA (1) | CA2679809A1 (es) |
| CL (1) | CL2008000593A1 (es) |
| EC (1) | ECSP099612A (es) |
| IL (1) | IL200639A0 (es) |
| MX (1) | MX2009009416A (es) |
| PE (1) | PE20090111A1 (es) |
| RU (1) | RU2009136263A (es) |
| TW (1) | TW200843756A (es) |
| WO (1) | WO2008108958A2 (es) |
| ZA (1) | ZA200906062B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009029609A1 (en) * | 2007-08-27 | 2009-03-05 | Wyeth | Imidazopyridine analogs and their use as agonists of the wnt-beta-catenin cellular messaging system |
| CA2737694C (en) * | 2008-09-26 | 2013-07-02 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| WO2010101246A1 (ja) * | 2009-03-05 | 2010-09-10 | 塩野義製薬株式会社 | Ｎｐｙ ｙ５受容体拮抗作用を有するピペリジンおよびピロリジン誘導体 |
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| BR112012011518B8 (pt) * | 2009-11-18 | 2023-01-10 | Astrazeneca Ab | Compostos, composição farmacêutica, kit e usos de um composto |
| DK2519522T3 (en) | 2009-12-30 | 2014-12-08 | Arqule Inc | SUBSTITUTED IDAZOPYRIDINYL AMINOPYRIDINE COMPOUNDS |
| WO2012020725A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体 |
| TW201242962A (en) | 2010-12-01 | 2012-11-01 | Sumitomo Chemical Co | Pyrimidine compound and use for pest control thereof |
| CN103492377B (zh) * | 2011-02-25 | 2016-04-20 | 阵列生物制药公司 | 作为pim激酶抑制剂的三唑并吡啶化合物 |
| JP2014114212A (ja) * | 2011-03-29 | 2014-06-26 | Dainippon Sumitomo Pharma Co Ltd | 新規ベンズイミダゾール誘導体 |
| WO2012158117A1 (en) * | 2011-05-17 | 2012-11-22 | Astrazeneca Ab | Combination therapies for treating pain |
| WO2012177852A1 (en) | 2011-06-24 | 2012-12-27 | Arqule, Inc | Substituted imidazopyridinyl compounds |
| KR101974673B1 (ko) | 2011-06-24 | 2019-05-02 | 아르퀼 인코포레이티드 | 치환된 이미다조피리디닐-아미노피리딘 화합물 |
| US9527839B2 (en) | 2012-08-22 | 2016-12-27 | Merck Sharp & Dohme Corp. | Benzimidazole tetrahydropyran derivatives |
| WO2014102594A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| WO2014160478A1 (en) * | 2013-03-13 | 2014-10-02 | Flatley Discovery Lab | Compounds and methods for the treatment of cystic fibrosis |
| JP6539274B2 (ja) | 2013-08-12 | 2019-07-03 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド | 押出成形された即放性乱用抑止性丸剤 |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2016010771A1 (en) | 2014-07-17 | 2016-01-21 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| AU2015336065A1 (en) | 2014-10-20 | 2017-05-04 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| CN104860919B (zh) * | 2015-03-26 | 2017-11-10 | 天津药物研究院有限公司 | 含哌啶的苯并咪唑衍生物及其制备方法和用途 |
| WO2017082393A1 (ja) * | 2015-11-12 | 2017-05-18 | 学校法人 聖マリアンナ医科大学 | 緑内障予防治療剤 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6211199B1 (en) * | 1995-11-17 | 2001-04-03 | Aventis Pharmaceuticals Inc. | Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases |
| PL373586A1 (en) * | 2002-01-11 | 2005-09-05 | Abbott Laboratories | Histamine-3 receptor ligands for diabetic conditions |
| CA2482551C (en) * | 2002-04-18 | 2009-08-11 | Schering Corporation | 1-(4-piperidinyl) benzimidazolones as histamine h3 antagonists |
| US7105505B2 (en) * | 2002-04-18 | 2006-09-12 | Schering Corporation | Benzimidazole derivatives useful as histamine H3 antagonists |
| WO2007035703A1 (en) * | 2005-09-20 | 2007-03-29 | Schering Corporation | 1- [ [1- [ (2-amin0-6-methyl-4-pyridinyl) methyl] -4-flu0r0-4-piperidinyl,] carbonyl] -4- [2- (2-pyridinyl) -3h-imidaz0 [4 , 5-b] pyridin-3-yl] piperidine useful as histamine h3 antagonist |
| JP2009521445A (ja) * | 2005-12-21 | 2009-06-04 | シェーリング コーポレイション | Ｈ３アンタゴニスト／逆アゴニストと食欲抑制剤との組み合わせ |
-
2008
- 2008-02-27 EP EP08714248A patent/EP2114402A2/en not_active Withdrawn
- 2008-02-27 BR BRPI0808707-5A patent/BRPI0808707A2/pt not_active Application Discontinuation
- 2008-02-27 AU AU2008223513A patent/AU2008223513A1/en not_active Abandoned
- 2008-02-27 CA CA002679809A patent/CA2679809A1/en not_active Abandoned
- 2008-02-27 KR KR1020097020505A patent/KR20090127902A/ko not_active Withdrawn
- 2008-02-27 JP JP2009551714A patent/JP2010520201A/ja not_active Withdrawn
- 2008-02-27 AR ARP080100805A patent/AR065495A1/es not_active Application Discontinuation
- 2008-02-27 WO PCT/US2008/002594 patent/WO2008108958A2/en not_active Ceased
- 2008-02-27 CN CN200880014373A patent/CN101674827A/zh active Pending
- 2008-02-27 US US12/527,500 patent/US20100144591A1/en not_active Abandoned
- 2008-02-27 TW TW097106891A patent/TW200843756A/zh unknown
- 2008-02-27 MX MX2009009416A patent/MX2009009416A/es unknown
- 2008-02-27 RU RU2009136263/15A patent/RU2009136263A/ru unknown
- 2008-02-27 CL CL200800593A patent/CL2008000593A1/es unknown
- 2008-02-28 PE PE2008000405A patent/PE20090111A1/es not_active Application Discontinuation
-
2009
- 2009-08-30 IL IL200639A patent/IL200639A0/en unknown
- 2009-09-01 EC EC2009009612A patent/ECSP099612A/es unknown
- 2009-09-01 ZA ZA200906062A patent/ZA200906062B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR065495A1 (es) | 2009-06-10 |
| ECSP099612A (es) | 2009-10-30 |
| EP2114402A2 (en) | 2009-11-11 |
| CL2008000593A1 (es) | 2008-09-05 |
| KR20090127902A (ko) | 2009-12-14 |
| BRPI0808707A2 (pt) | 2014-09-09 |
| WO2008108958A2 (en) | 2008-09-12 |
| ZA200906062B (en) | 2010-05-26 |
| WO2008108958A3 (en) | 2009-05-07 |
| IL200639A0 (en) | 2010-05-17 |
| AU2008223513A1 (en) | 2008-09-12 |
| JP2010520201A (ja) | 2010-06-10 |
| TW200843756A (en) | 2008-11-16 |
| CN101674827A (zh) | 2010-03-17 |
| CA2679809A1 (en) | 2008-09-12 |
| US20100144591A1 (en) | 2010-06-10 |
| RU2009136263A (ru) | 2011-04-10 |
| WO2008108958A8 (en) | 2009-08-13 |
| MX2009009416A (es) | 2009-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |