PE20090504A1 - Compuestos heterociclicos antiviricos - Google Patents
Compuestos heterociclicos antiviricosInfo
- Publication number
- PE20090504A1 PE20090504A1 PE2008001245A PE2008001245A PE20090504A1 PE 20090504 A1 PE20090504 A1 PE 20090504A1 PE 2008001245 A PE2008001245 A PE 2008001245A PE 2008001245 A PE2008001245 A PE 2008001245A PE 20090504 A1 PE20090504 A1 PE 20090504A1
- Authority
- PE
- Peru
- Prior art keywords
- dimethyl
- methyl
- compounds
- piran
- imidazolidin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- -1 4,6-DIMETHYL-PYRIMIDIN-5-YL Chemical group 0.000 abstract 2
- 102000004274 CCR5 Receptors Human genes 0.000 abstract 1
- 108010017088 CCR5 Receptors Proteins 0.000 abstract 1
- 206010038997 Retroviral infections Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical group [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN COMPUESTO DE FORMULA I DONDE: R1 ES CICLOALQUILO (C3-C6), CICLOALQUIL (C3-C6)-ALQUILO(C1-C3), TETRAHIDROPIRANILO, ENTRE OTROS; R3 ES ALQUILO (C1-C6), PIRIDINILO, FENILO SUSTITUIDO O NO POR 1-3 HALOGENOS; R4 ES H, ALQUILO (C1-C3); R2 ES 4,6-DIMETIL-PIRIMIDIN-5-ILO, 2,4-DIMETIL-PIRIDIN-3-ILO, 2,4-DIMETIL-1-OXI-PIRIDIN-3-ILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-{4-[5-BUTIL-2-OXO-3-(TETRAHIDRO-PIRAN-4-IL)-IMIDAZOLIDIN-1-IL]-4-METIL-[1,4]BIPERIDINIL-1-CARBONIL}-4,6-DIMETIL-PIRIDINA-2-CARBONITRILO; 4-BUTIL-3-[1-(4,6-DIMETIL-PIRIMIDINA-5-CARBONIL)-4-METIL-[1,4]BIPIRIDINIL-4-IL]-1-(TETRAHIDRO-PIRAN-4-IL)-IMIDAZOLIDIN-2-ONA; (R)-3-3[4'-METIL-1'-(3-METIL-5-TRIFLUORMETIL-ISOXAZOL-4-CARBONIL)-[1,4']BIPIPERIDINIL-4-IL]-4-FENIL-1-(TETRAHIDRO-PIRAN-4-ILMETIL)-IMIDAZOLIDIN-2-ONA; ENTRE OTROS. TAMBIEN SE REFIERE UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SOBRE LA MODULACION DE LOS RECEPTORES CCR5 SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES RETROVIRICAS DEL VIH, ARTRITIS REUMATOIDE, ASMA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96178407P | 2007-07-24 | 2007-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090504A1 true PE20090504A1 (es) | 2009-04-29 |
Family
ID=40281884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008001245A PE20090504A1 (es) | 2007-07-24 | 2008-07-22 | Compuestos heterociclicos antiviricos |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090028818A1 (es) |
| AR (1) | AR067640A1 (es) |
| PE (1) | PE20090504A1 (es) |
| TW (1) | TW200916460A (es) |
| WO (1) | WO2009013171A2 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100665299B1 (ko) * | 2004-06-10 | 2007-01-04 | 서울반도체 주식회사 | 발광물질 |
| JP6478923B2 (ja) | 2013-02-07 | 2019-03-06 | ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | ムスカリンｍ４受容体アゴニストとしてのピペリジン−１−イル及びアゼピン−１−イルカルボキシレート |
| PH12018502378B1 (en) | 2016-05-20 | 2022-08-05 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
| WO2018106284A1 (en) | 2016-12-09 | 2018-06-14 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| CA3103600A1 (en) | 2018-06-13 | 2019-12-19 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| US10752623B2 (en) | 2018-08-31 | 2020-08-25 | Xenon Pharmaceuticals Inc. | Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors |
| MX2021001380A (es) | 2018-08-31 | 2021-05-27 | Xenon Pharmaceuticals Inc | Compuestos de sulfonamida sustituidos con heteroarilo y su uso como agentes terapeuticos. |
| CN112220771B (zh) * | 2020-11-10 | 2023-03-31 | 成都大学 | 扎西他滨渗透泵型控释片及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4407961A1 (de) * | 1994-03-10 | 1995-09-14 | Thomae Gmbh Dr K | Imidazolidin-2-one, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| JP2010512340A (ja) * | 2006-12-06 | 2010-04-22 | ジェンザイム・コーポレーション | ケモカイン受容体結合性化合物 |
-
2008
- 2008-07-14 WO PCT/EP2008/059186 patent/WO2009013171A2/en not_active Ceased
- 2008-07-22 PE PE2008001245A patent/PE20090504A1/es not_active Application Discontinuation
- 2008-07-22 AR ARP080103165A patent/AR067640A1/es unknown
- 2008-07-23 TW TW097128017A patent/TW200916460A/zh unknown
- 2008-07-24 US US12/220,485 patent/US20090028818A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AR067640A1 (es) | 2009-10-21 |
| WO2009013171A2 (en) | 2009-01-29 |
| WO2009013171A3 (en) | 2009-04-09 |
| US20090028818A1 (en) | 2009-01-29 |
| TW200916460A (en) | 2009-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |