PE20081312A1 - MACROCYCLIC TETRAZOLYLS AS SERINE PROTEASE INHIBITORS OF HEPATITIS C - Google Patents
MACROCYCLIC TETRAZOLYLS AS SERINE PROTEASE INHIBITORS OF HEPATITIS CInfo
- Publication number
- PE20081312A1 PE20081312A1 PE2007001035A PE2007001035A PE20081312A1 PE 20081312 A1 PE20081312 A1 PE 20081312A1 PE 2007001035 A PE2007001035 A PE 2007001035A PE 2007001035 A PE2007001035 A PE 2007001035A PE 20081312 A1 PE20081312 A1 PE 20081312A1
- Authority
- PE
- Peru
- Prior art keywords
- hepatitis
- macrocyclic
- aryl
- serine protease
- tetrazolyls
- Prior art date
Links
- 208000006454 hepatitis Diseases 0.000 title abstract 2
- 231100000283 hepatitis Toxicity 0.000 title abstract 2
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 241000711549 Hepacivirus C Species 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A COMPUESTOS DE TETRAZOLILOS MACROCICLICOS DE FORMULAS (I),(II),(III),(IV),(V),(VI),(VII) O (VIII), EN DONDE A ES R1, -(C=O)-O-R1, -C(=O)-NH-R2, ENTRE OTROS; R1 ES ARILO, HETEROARILO, HETEROCICLOALQUILO, ENTRE OTROS; G ES NSH(O)2-R3 Y NH(SO)2NR4R5; R3 ES ARILO, HETEROARILO, HETEROCICLOALQUILO, ENTRE OTROS; R4 Y R5 SON INDEPENDIENTEMENTE H, ARILO, HETEROCICLOALQUILO, ENTRE OTROS; L ES-CH2-, -O-, -S- Y -S(O)2-; X ES H, ARILO, HETEROARILO, ENTRE OTROS; j ES 0,1,2,3 O 4; k ES 1,2 O 3; m ES 0,1 O 2; n ES 1,2 O 3. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE SERINA PROTEASA, PARTICULARMENTE LA ACTIVIDAD DE LA NS3-NS4A PROTEASA DEL VIRUS DE HEPATITIS C (VHC) SIENDO UTILES EN EL TRATAMIENTO DE HEPATITIS C Y COMO AGENTES ANTIVIRALESREFERS TO MACROCYCLIC TETRAZOLYL COMPOUNDS OF FORMULAS (I), (II), (III), (IV), (V), (VI), (VII) OR (VIII), WHERE A IS R1, - (C = O) -O-R1, -C (= O) -NH-R2, AMONG OTHERS; R1 IS ARYL, HETEROARYL, HETEROCYCLOALKYL, AMONG OTHERS; G IS NSH (O) 2-R3 AND NH (SO) 2NR4R5; R3 IS ARYL, HETEROARIL, HETEROCYCLOALKYL, AMONG OTHERS; R4 AND R5 ARE INDEPENDENTLY H, ARYL, HETEROCICLOALKYL, AMONG OTHERS; L IS-CH2-, -O-, -S- AND -S (O) 2-; X IS H, ARYL, HETEROARYL, AMONG OTHERS; j ES 0,1,2,3 O 4; k IS 1,2 O 3; m IS 0.1 O 2; n IS 1,2 OR 3. ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PREPARATION PROCEDURE. THESE COMPOUNDS ARE INHIBITORS OF SERINE PROTEASE, PARTICULARLY THE ACTIVITY OF THE NS3-NS4A PROTEASE OF THE HEPATITIS C VIRUS (HCV), BEING USEFUL IN THE TREATMENT OF HEPATITIS C AND AS ANTIVIRAL AGENTS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49924506A | 2006-08-04 | 2006-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081312A1 true PE20081312A1 (en) | 2008-09-17 |
Family
ID=40981968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001035A PE20081312A1 (en) | 2006-08-04 | 2007-08-06 | MACROCYCLIC TETRAZOLYLS AS SERINE PROTEASE INHIBITORS OF HEPATITIS C |
Country Status (3)
| Country | Link |
|---|---|
| CO (1) | CO6020003A1 (en) |
| PE (1) | PE20081312A1 (en) |
| TW (1) | TW200920394A (en) |
-
2007
- 2007-08-03 TW TW96128596A patent/TW200920394A/en unknown
- 2007-08-06 CO CO07080058A patent/CO6020003A1/en not_active Application Discontinuation
- 2007-08-06 PE PE2007001035A patent/PE20081312A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CO6020003A1 (en) | 2009-03-31 |
| TW200920394A (en) | 2009-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |