CO6020003A1 - TETRAZOLILOS MACROCICLICOS AS INHIBITORS OF SERINE PROTEASE OF HEPATITIS C - Google Patents
TETRAZOLILOS MACROCICLICOS AS INHIBITORS OF SERINE PROTEASE OF HEPATITIS CInfo
- Publication number
- CO6020003A1 CO6020003A1 CO07080058A CO07080058A CO6020003A1 CO 6020003 A1 CO6020003 A1 CO 6020003A1 CO 07080058 A CO07080058 A CO 07080058A CO 07080058 A CO07080058 A CO 07080058A CO 6020003 A1 CO6020003 A1 CO 6020003A1
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- heterocycloalkyl
- heteroaryl
- aryl
- alkenyl
- Prior art date
Links
- 102000012479 Serine Proteases Human genes 0.000 title 1
- 108010022999 Serine Proteases Proteins 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 6
- 125000005842 heteroatom Chemical group 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Un compuesto de Formula I, II, III o IV:<EMI FILE="07080058_1" ID="1" IMF=JPEG HE=50 WI=50 >o sus sales aceptables para uso farmacéutico, ésteres o prodrogas, CARACTERIZADO PORQUEA se selecciona entre el grupo que consiste de R1, -(C=O)-O-R1, -(C=O)-R2, -C(=O)-NH-R2, y -S(O)2-R1, -S(O)2NHR2;R1 se selecciona entre el grupo formado por:(i) arilo; arilo sustituido; heteroarilo; heteroarilo sustituido;(ii) heterocicloalquilo o heterocicloalquilo sustituido; y(iii) -C1-C8 alquilo, -C2-C8 alquenilo, o C2-C8 alquinilo cada uno con 0, 1, 2, o 3 heteroátomos seleccionados entre O, S, o N; -C1-C8 alquilo sustituido, -C2-C8 alquenilo sustituido, o C2-C8 alquinilo sustituido cada uno con 0, 1, 2, o 3 heteroátomos seleccionados entre O, S o N; -C3-C12 cicloalquilo, o C3-C12 cicloalquilo sustituido; -C3-C12 cicloalquenilo, o -C3-C12 cicloalquenilo sustituido;R2 se selecciona en forma independiente entre el grupo formado por:(i) hidrógeno;(ii) arilo; arilo sustituido; heteroarilo; heteroarilo sustituido; (iii) heterocicloalquilo o heterocicloalquilo sustituido; y(iv) -C1-C8 alquilo, -C2-C8 alquenilo, o C2-C8 alquinilo cada uno con 0, 1, 2, o 3 heteroátomos seleccionados entre O, S, o N; -C1-C8 alquilo sustituido, -C2-C8 alquenilo sustituido, o C2-C8 alquinilo sustituido cada uno con 0, 1, 2, o 3 heteroátomos seleccionados entre O, S o N; -C3-C12 cicloalquilo, o C3-C12 cicloalquilo sustituido; -C3-C12 cicloalquenilo, o -C3-C12 cicloalquenilo sustituido;G se selecciona entre el grupo que consiste de -NHS(O)2-R3 y - NH(SO2)NR4R5;R3 se selecciona entre el grupo formado por:(i) arilo; arilo sustituido; heteroarilo; heteroarilo sustituido(ii) heterocicloalquilo o heterocicloalquilo sustituido; y(iii) -C1-C8 alquilo, -C2-C8 alquenilo, ...A compound of Formula I, II, III or IV: <EMI FILE = "07080058_1" ID = "1" MFI = JPEG HE = 50 WI = 50> or its salts acceptable for pharmaceutical use, esters or prodrugs, CHARACTERIZED BECAUSE between the group consisting of R1, - (C = O) -O-R1, - (C = O) -R2, -C (= O) -NH-R2, and -S (O) 2-R1, - S (O) 2NHR2; R1 is selected from the group consisting of: (i) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (ii) heterocycloalkyl or substituted heterocycloalkyl; and (iii) -C1-C8 alkyl, -C2-C8 alkenyl, or C2-C8 alkynyl each with 0, 1, 2, or 3 heteroatoms selected from O, S, or N; -C1-C8 substituted alkyl, -C2-C8 substituted alkenyl, or C2-C8 substituted alkynyl each with 0, 1, 2, or 3 heteroatoms selected from O, S or N; -C3-C12 cycloalkyl, or C3-C12 substituted cycloalkyl; -C3-C12 cycloalkenyl, or -C3-C12 substituted cycloalkenyl; R2 is independently selected from the group consisting of: (i) hydrogen; (ii) aryl; substituted aryl; heteroaryl; substituted heteroaryl; (iii) heterocycloalkyl or substituted heterocycloalkyl; and (iv) -C1-C8 alkyl, -C2-C8 alkenyl, or C2-C8 alkynyl each with 0, 1, 2, or 3 heteroatoms selected from O, S, or N; -C1-C8 substituted alkyl, -C2-C8 substituted alkenyl, or C2-C8 substituted alkynyl each with 0, 1, 2, or 3 heteroatoms selected from O, S or N; -C3-C12 cycloalkyl, or C3-C12 substituted cycloalkyl; -C3-C12 cycloalkenyl, or -C3-C12 substituted cycloalkenyl; G is selected from the group consisting of -NHS (O) 2-R3 and - NH (SO2) NR4R5; R3 is selected from the group consisting of: (i ) aryl; substituted aryl; heteroaryl; substituted heteroaryl (ii) heterocycloalkyl or substituted heterocycloalkyl; and (iii) -C1-C8 alkyl, -C2-C8 alkenyl, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49924506A | 2006-08-04 | 2006-08-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6020003A1 true CO6020003A1 (en) | 2009-03-31 |
Family
ID=40981968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO07080058A CO6020003A1 (en) | 2006-08-04 | 2007-08-06 | TETRAZOLILOS MACROCICLICOS AS INHIBITORS OF SERINE PROTEASE OF HEPATITIS C |
Country Status (3)
| Country | Link |
|---|---|
| CO (1) | CO6020003A1 (en) |
| PE (1) | PE20081312A1 (en) |
| TW (1) | TW200920394A (en) |
-
2007
- 2007-08-03 TW TW96128596A patent/TW200920394A/en unknown
- 2007-08-06 PE PE2007001035A patent/PE20081312A1/en not_active Application Discontinuation
- 2007-08-06 CO CO07080058A patent/CO6020003A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200920394A (en) | 2009-05-16 |
| PE20081312A1 (en) | 2008-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |