PE20081162A1 - Pirazoles sustituidos, composiciones que los contienen, procedimientos de fabricacion y utilizacion - Google Patents
Pirazoles sustituidos, composiciones que los contienen, procedimientos de fabricacion y utilizacionInfo
- Publication number
- PE20081162A1 PE20081162A1 PE2007001548A PE2007001548A PE20081162A1 PE 20081162 A1 PE20081162 A1 PE 20081162A1 PE 2007001548 A PE2007001548 A PE 2007001548A PE 2007001548 A PE2007001548 A PE 2007001548A PE 20081162 A1 PE20081162 A1 PE 20081162A1
- Authority
- PE
- Peru
- Prior art keywords
- amino
- alkyl
- manufacturing
- compositions containing
- substituted pyrazoles
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000000203 mixture Chemical class 0.000 title 1
- 150000003217 pyrazoles Chemical class 0.000 title 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- KKFDJZZADQONDE-UHFFFAOYSA-N (hydridonitrato)hydroxidocarbon(.) Chemical compound O[C]=N KKFDJZZADQONDE-UHFFFAOYSA-N 0.000 abstract 1
- 101100134925 Gallus gallus COR6 gene Proteins 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL, DE FORMULA I, DONDE A Y Ar SON ARILO, ARILO SUSTITUIDO, HETEROARILO, HETEROARILO SUSTITUIDO; L ES NH-CO-NH Y O-CO-NH; R1 ES H, R6, COR6, SO2R6; R6 ES H, ALQUILO, HETEROARILO, HETEROCICLILO, ENTRE OTROS; X ES O, NH; R3 ES H, ALQUILO, CICLOALQUILO SUSTITUIDOS O NO; R4a Y R4b SON CADA UNO H, ALQUILO C1-C4; R5 ES H, HALOGENO, OC(O)(R10), C(=N(OR11))(R10), ENTRE OTROS; R10 Y R11 SON CADA UNO ALQUILO, ALQUILENO, CICLOALQUILO, ENTRE OTROS. SON PREFERIDOS: TRIFLUOROACETATO DE 4-({[3-FENIL]CARBAMOIL}OXI)BENCIL]AMINO}-1H-PIRAZOL-3-CARBOXAMIDA; TRIFLUOROACETATO DE 4-{[3-({[3-FLUORO-5-(TRIFLUOROMETIL)FENIL]CARBAMOIL}AMINO)BENCIL]AMINO}-1H-PIRAZOL-3-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON MODULADORES DE ENZIMAS QUINASAS, UTILES COMO ANTICANCERIGENOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0609812A FR2908409B1 (fr) | 2006-11-10 | 2006-11-10 | Pyrazoles substituees,compositions les contenant,procede de fabrication et utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081162A1 true PE20081162A1 (es) | 2008-10-02 |
Family
ID=38169388
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001548A PE20081162A1 (es) | 2006-11-10 | 2007-11-09 | Pirazoles sustituidos, composiciones que los contienen, procedimientos de fabricacion y utilizacion |
| PE2012000296A PE20121152A1 (es) | 2006-11-10 | 2007-11-09 | Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000296A PE20121152A1 (es) | 2006-11-10 | 2007-11-09 | Pirazoles sustituidos, composiciones que los contienen, procedimiento de fabricacion y utilizacion |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US7989439B2 (es) |
| EP (1) | EP2091920B1 (es) |
| JP (1) | JP5538893B2 (es) |
| KR (1) | KR20090083456A (es) |
| CN (1) | CN101553473B (es) |
| AR (1) | AR063638A1 (es) |
| AU (1) | AU2007327423B2 (es) |
| BR (1) | BRPI0718999A2 (es) |
| CA (1) | CA2667846A1 (es) |
| CL (1) | CL2007003251A1 (es) |
| CO (1) | CO6190516A2 (es) |
| CR (1) | CR10749A (es) |
| CY (1) | CY1116000T1 (es) |
| DK (1) | DK2091920T3 (es) |
| DO (1) | DOP2009000088A (es) |
| EA (1) | EA019454B1 (es) |
| EC (1) | ECSP099312A (es) |
| ES (1) | ES2528385T3 (es) |
| FR (1) | FR2908409B1 (es) |
| HN (1) | HN2009000856A (es) |
| HR (1) | HRP20150070T1 (es) |
| IL (1) | IL198328A0 (es) |
| MA (1) | MA30972B1 (es) |
| MX (1) | MX2009004983A (es) |
| MY (1) | MY147502A (es) |
| NI (1) | NI200900078A (es) |
| NO (1) | NO20091990L (es) |
| NZ (1) | NZ576709A (es) |
| PE (2) | PE20081162A1 (es) |
| PL (1) | PL2091920T3 (es) |
| PT (1) | PT2091920E (es) |
| SI (1) | SI2091920T1 (es) |
| SV (1) | SV2009003253A (es) |
| TN (1) | TN2009000155A1 (es) |
| TW (1) | TW200829556A (es) |
| UA (1) | UA97965C2 (es) |
| UY (1) | UY30707A1 (es) |
| WO (1) | WO2008065282A2 (es) |
| ZA (1) | ZA200903560B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7858323B2 (en) * | 2004-06-09 | 2010-12-28 | The Regents Of The University Of Michigan | Phage microarray profiling of the humoral response to disease |
| FR2947546B1 (fr) | 2009-07-03 | 2011-07-01 | Sanofi Aventis | Derives de pyrazoles, leur preparation et leur application en therapeutique |
| TWI532725B (zh) * | 2010-01-26 | 2016-05-11 | 賽諾菲阿凡提斯公司 | 經氧取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途 |
| TWI523844B (zh) * | 2011-01-26 | 2016-03-01 | 賽諾菲公司 | 經胺基取代之３－雜芳醯基胺基－丙酸衍生物及其作為藥物之用途 |
| CN102432639B (zh) * | 2011-09-30 | 2013-11-06 | 山东大学 | 1-(2-羟基-3-(苯氨基)丙基)-3-二茂铁基-1h-吡唑-5-甲酸乙酯化合物及其应用 |
| KR101668574B1 (ko) | 2012-11-02 | 2016-10-24 | 화이자 인코포레이티드 | 브루톤 티로신 키나제 억제제 |
| JP6695353B2 (ja) * | 2015-03-25 | 2020-05-20 | ノバルティス アーゲー | Ｆｇｆｒ４阻害剤としてのホルミル化ｎ−複素環式誘導体 |
| CN107619388A (zh) * | 2016-07-13 | 2018-01-23 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| CN107840842A (zh) | 2016-09-19 | 2018-03-27 | 北京天诚医药科技有限公司 | 炔代杂环化合物、其制备方法及其在医药学上的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6878714B2 (en) * | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| CA2445357A1 (en) * | 2001-04-27 | 2002-11-07 | Vertex Pharmaceuticals Incorporated | Pyrazole derived kinase inhibitors |
| BRPI0409427A (pt) * | 2003-04-16 | 2006-04-18 | Astrazeneca Ab | composto, uso do mesmo, composição farmacêutica, método de tratamento de um humano sofrendo de uma doença hiperproliferativa, e, processo para a preparação de um composto ou de um sal, éster ou pró-droga farmaceuticamente aceitáveis do mesmo |
| US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
| NZ544756A (en) * | 2003-07-22 | 2009-09-25 | Astex Therapeutics Ltd | 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
| EP1781653A1 (en) * | 2004-07-05 | 2007-05-09 | Astex Therapeutics Limited | 3,4-disubstituted pyrazoles as cyclin dependent kinases (cdk) or aurora kinase or glycogen synthase 3 (gsk-3) inhibitors |
| EP1786422A2 (en) * | 2004-08-16 | 2007-05-23 | Prosidion Limited | Aryl urea derivatives for treating obesity |
| JP2008526723A (ja) * | 2004-12-30 | 2008-07-24 | アステックス、セラピューティックス、リミテッド | Ｃｄｋ、ｇｓｋ及びオーロラキナーゼの活性を調節するピラゾール誘導体 |
| JP2008528469A (ja) * | 2005-01-21 | 2008-07-31 | アステックス・セラピューティクス・リミテッド | ピラゾールキナーゼ阻害剤およびさらなる抗癌剤の組合せ剤 |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| EP1683796A1 (en) * | 2005-01-24 | 2006-07-26 | Schering Aktiengesellschaft | Pyrazolopyridines, their preparation and their medical use |
| FR2947546B1 (fr) * | 2009-07-03 | 2011-07-01 | Sanofi Aventis | Derives de pyrazoles, leur preparation et leur application en therapeutique |
-
2006
- 2006-11-10 FR FR0609812A patent/FR2908409B1/fr not_active Expired - Fee Related
-
2007
- 2007-11-08 TW TW096142249A patent/TW200829556A/zh unknown
- 2007-11-09 PE PE2007001548A patent/PE20081162A1/es not_active Application Discontinuation
- 2007-11-09 NZ NZ576709A patent/NZ576709A/en not_active IP Right Cessation
- 2007-11-09 HR HRP20150070TT patent/HRP20150070T1/hr unknown
- 2007-11-09 CA CA002667846A patent/CA2667846A1/fr not_active Abandoned
- 2007-11-09 AR ARP070105002A patent/AR063638A1/es not_active Application Discontinuation
- 2007-11-09 EP EP07870263.6A patent/EP2091920B1/fr active Active
- 2007-11-09 CL CL2007003251A patent/CL2007003251A1/es unknown
- 2007-11-09 KR KR1020097011936A patent/KR20090083456A/ko not_active Abandoned
- 2007-11-09 ES ES07870263.6T patent/ES2528385T3/es active Active
- 2007-11-09 WO PCT/FR2007/001851 patent/WO2008065282A2/fr not_active Ceased
- 2007-11-09 CN CN200780045533XA patent/CN101553473B/zh not_active Expired - Fee Related
- 2007-11-09 PE PE2012000296A patent/PE20121152A1/es not_active Application Discontinuation
- 2007-11-09 MX MX2009004983A patent/MX2009004983A/es active IP Right Grant
- 2007-11-09 UA UAA200905930A patent/UA97965C2/ru unknown
- 2007-11-09 EA EA200970472A patent/EA019454B1/ru not_active IP Right Cessation
- 2007-11-09 BR BRPI0718999-0A2A patent/BRPI0718999A2/pt not_active IP Right Cessation
- 2007-11-09 JP JP2009535773A patent/JP5538893B2/ja not_active Expired - Fee Related
- 2007-11-09 ZA ZA200903560A patent/ZA200903560B/xx unknown
- 2007-11-09 PT PT78702636T patent/PT2091920E/pt unknown
- 2007-11-09 SI SI200731592T patent/SI2091920T1/sl unknown
- 2007-11-09 DK DK07870263.6T patent/DK2091920T3/en active
- 2007-11-09 UY UY30707A patent/UY30707A1/es not_active Application Discontinuation
- 2007-11-09 MY MYPI20091827A patent/MY147502A/en unknown
- 2007-11-09 AU AU2007327423A patent/AU2007327423B2/en not_active Ceased
- 2007-11-09 PL PL07870263T patent/PL2091920T3/pl unknown
-
2009
- 2009-04-23 DO DO2009000088A patent/DOP2009000088A/es unknown
- 2009-04-23 IL IL198328A patent/IL198328A0/en unknown
- 2009-04-24 TN TNP2009000155A patent/TN2009000155A1/fr unknown
- 2009-04-24 CR CR10749A patent/CR10749A/es unknown
- 2009-05-05 EC EC2009009312A patent/ECSP099312A/es unknown
- 2009-05-06 NI NI200900078A patent/NI200900078A/es unknown
- 2009-05-07 SV SV2009003253A patent/SV2009003253A/es unknown
- 2009-05-07 CO CO09046036A patent/CO6190516A2/es active IP Right Grant
- 2009-05-08 HN HN2009000856A patent/HN2009000856A/es unknown
- 2009-05-08 US US12/437,618 patent/US7989439B2/en not_active Expired - Fee Related
- 2009-05-22 NO NO20091990A patent/NO20091990L/no not_active Application Discontinuation
- 2009-06-05 MA MA31959A patent/MA30972B1/fr unknown
-
2011
- 2011-06-09 US US13/156,915 patent/US8410286B2/en not_active Expired - Fee Related
- 2011-06-09 US US13/156,947 patent/US8420824B2/en not_active Expired - Fee Related
-
2015
- 2015-01-22 CY CY20151100068T patent/CY1116000T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| AE | Restoration of lapsed or forfeited application | ||
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |