[go: up one dir, main page]

PE20081133A1 - Cristal acetato de 3-(1h-indol-3-il)-4-[2-(4-metil-piperazin-1-il)-quinazolin-4-il]-pirrol-2,5-diona - Google Patents

Cristal acetato de 3-(1h-indol-3-il)-4-[2-(4-metil-piperazin-1-il)-quinazolin-4-il]-pirrol-2,5-diona

Info

Publication number
PE20081133A1
PE20081133A1 PE2007001411A PE2007001411A PE20081133A1 PE 20081133 A1 PE20081133 A1 PE 20081133A1 PE 2007001411 A PE2007001411 A PE 2007001411A PE 2007001411 A PE2007001411 A PE 2007001411A PE 20081133 A1 PE20081133 A1 PE 20081133A1
Authority
PE
Peru
Prior art keywords
diona
quinazolin
pyrrol
piperazin
indol
Prior art date
Application number
PE2007001411A
Other languages
English (en)
Inventor
Piotr Karpinski
Dimitris Papoutsakis
Paul Allen Sutton
Stephanie Monnier
Elias Ndzie
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38921707&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20081133(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20081133A1 publication Critical patent/PE20081133A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UNA FORMA CRISTALINA DEL COMPUESTO ACETATO DE 3-(1H-INDOL-3-IL)-4-[2-(4-METIL-PIPERAZIN-1-IL)-QUINAZOLIN-4-IL]-PIRROL-2,5-DIONA, SELECCIONADA DE A, B, SA, O MEZCLAS DE LAS MISMAS EN FORMA DE ANHIDRATO. DICHO CRISTAL TIENE UN PICO DE DIFRACCION EN UN ANGULO DE 2TETA DE 9.7º, 21.5º. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION SIENDO UTIL EN LA PREVENCION O TRATAMIENTO DE ENFERMEDADES MEDIADAS POR LINFOCITOS T O PKC TALES COMO EL RECHAZO A TRASPLANTES, ENFERMEDADES AUTOINMUNES Y/O HIPERPROLIFERATIVAS
PE2007001411A 2006-10-20 2007-10-18 Cristal acetato de 3-(1h-indol-3-il)-4-[2-(4-metil-piperazin-1-il)-quinazolin-4-il]-pirrol-2,5-diona PE20081133A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85338406P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
PE20081133A1 true PE20081133A1 (es) 2008-09-16

Family

ID=38921707

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001411A PE20081133A1 (es) 2006-10-20 2007-10-18 Cristal acetato de 3-(1h-indol-3-il)-4-[2-(4-metil-piperazin-1-il)-quinazolin-4-il]-pirrol-2,5-diona

Country Status (23)

Country Link
US (1) US8865897B2 (es)
EP (1) EP2102195A1 (es)
JP (1) JP5302199B2 (es)
KR (1) KR20090073231A (es)
CN (2) CN103265533A (es)
AR (1) AR063491A1 (es)
AU (1) AU2007309558B2 (es)
BR (1) BRPI0717461A2 (es)
CA (1) CA2666965A1 (es)
CL (1) CL2007003006A1 (es)
EC (1) ECSP099344A (es)
IL (1) IL197962A (es)
MA (1) MA30886B1 (es)
MX (1) MX2009004048A (es)
MY (1) MY158026A (es)
NO (1) NO20091970L (es)
NZ (1) NZ576241A (es)
PE (1) PE20081133A1 (es)
RU (1) RU2481341C2 (es)
TN (1) TN2009000147A1 (es)
TW (1) TWI399374B (es)
WO (1) WO2008051440A1 (es)
ZA (1) ZA200902048B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0808354A2 (pt) * 2007-03-09 2014-07-29 Novartis Ag Sais de 3-(1h-indol-3-il)-4-[2-(4-metil-piperazin-1-il)-quinazolin-4 -il]-pirrola-2,5-diona
US9017528B2 (en) 2011-04-14 2015-04-28 Tel Nexx, Inc. Electro chemical deposition and replenishment apparatus
US9005409B2 (en) 2011-04-14 2015-04-14 Tel Nexx, Inc. Electro chemical deposition and replenishment apparatus
US9303329B2 (en) 2013-11-11 2016-04-05 Tel Nexx, Inc. Electrochemical deposition apparatus with remote catholyte fluid management

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100748386B1 (ko) * 2000-11-07 2007-08-10 노파르티스 아게 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체
GB0504203D0 (en) * 2005-03-01 2005-04-06 Novartis Ag Organic compounds
CA2690243A1 (en) 2007-06-18 2008-12-24 Sanofi-Aventis Pyrrole derivatives as p2y12 antagonists

Also Published As

Publication number Publication date
CN101522664B (zh) 2013-06-12
JP5302199B2 (ja) 2013-10-02
WO2008051440A1 (en) 2008-05-02
MX2009004048A (es) 2009-04-27
NZ576241A (en) 2012-05-25
KR20090073231A (ko) 2009-07-02
AU2007309558A1 (en) 2008-05-02
US20100041884A1 (en) 2010-02-18
RU2009118816A (ru) 2010-11-27
IL197962A (en) 2013-08-29
MA30886B1 (fr) 2009-11-02
ECSP099344A (es) 2009-06-30
EP2102195A1 (en) 2009-09-23
CL2007003006A1 (es) 2008-05-23
CA2666965A1 (en) 2008-05-02
AR063491A1 (es) 2009-01-28
TWI399374B (zh) 2013-06-21
TN2009000147A1 (en) 2010-10-18
BRPI0717461A2 (pt) 2013-10-08
TW200829572A (en) 2008-07-16
US8865897B2 (en) 2014-10-21
ZA200902048B (en) 2010-01-27
CN103265533A (zh) 2013-08-28
AU2007309558B2 (en) 2012-05-24
CN101522664A (zh) 2009-09-02
IL197962A0 (en) 2009-12-24
MY158026A (en) 2016-08-30
NO20091970L (no) 2009-05-20
RU2481341C2 (ru) 2013-05-10
JP2010506927A (ja) 2010-03-04

Similar Documents

Publication Publication Date Title
HK1206597A1 (en) Spirocyclic dihydro-thiazine and dihydro-oxazine bace inhibitors, and compositions and uses thereof
CL2008000690A1 (es) Compuestos derivados del acido indol-3-propionico; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hiperlipidemia, hipertension; entre otras.
AU2012243329A8 (en) 5-substituted iminothiazines and their mono-and dioxides as BACE inhibitors,compositions,and their use
PE20180021A1 (es) Derivados de sobetiroma
SG179034A1 (en) 2 -aminodihydro [1, 3] thiazines as bace 2 inhibitors for the treatment of diabetes
HK1215579A1 (zh) 被取代的2，3-二氫苯並呋喃基化合物和其用途
MX2013014007A (es) [1,3] oxazinas.
WO2008040649A3 (en) Pyrazine-2-carboxamide derivatives as cb2 receptor modulators
CL2008001994A1 (es) Compuestos derivados de pirazin-2-ona; combinacion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, aterosclerosis, hipertension, entre otras.
WO2014106238A8 (en) Heterocyclic compounds and methods of use thereof
TW200806300A (en) New therapeutic combinations for the treatment of depression
GEP20186880B (en) 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tetrahydropyridines as bace1 inhibitors for treatment of alzheimer's disease
MX2008013196A (es) 5-amido-2-carboxiamida-indoles.
PT2139334E (pt) Compostos heterocíclicos fusionados de 2-cianofenilo, e composições e utilizações dos mesmos
MX2011010449A (es) Derivados de oxadiazol.
TW200738651A (en) Cyclohexyl sulfonamide derivatives
PH12013501321A1 (en) Phenoxymethyl heterocyclic compounds
WO2009124962A3 (en) Sulfonamides
ATE450522T1 (de) Neue thiophensulfoximine zur behandlung von komplementvermittelten krankheiten und leiden
NZ597866A (en) Therapeutic lactams
WO2007131907A3 (en) 1h-indol-5-yl-piperazin-1-yl-methanone derivatives
PE20081133A1 (es) Cristal acetato de 3-(1h-indol-3-il)-4-[2-(4-metil-piperazin-1-il)-quinazolin-4-il]-pirrol-2,5-diona
EA201070495A1 (ru) МОДУЛЯТОРЫ АКТИВНОСТИ γ-СЕКРЕТАЗЫ ИЗ ГРУППЫ ПИПЕРИДИНИЛА И ПИПЕРАЗИНИЛА
WO2005075450A3 (en) Spiro-benzodioxoles and their use as cb1 antagonists
TW200626158A (en) Naphthaline derivatives

Legal Events

Date Code Title Description
FC Refusal