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PE20081120A1 - Derivados de hidantoina como inhibidores de metaloproteinasas de matriz (mmp) - Google Patents

Derivados de hidantoina como inhibidores de metaloproteinasas de matriz (mmp)

Info

Publication number
PE20081120A1
PE20081120A1 PE2007001670A PE2007001670A PE20081120A1 PE 20081120 A1 PE20081120 A1 PE 20081120A1 PE 2007001670 A PE2007001670 A PE 2007001670A PE 2007001670 A PE2007001670 A PE 2007001670A PE 20081120 A1 PE20081120 A1 PE 20081120A1
Authority
PE
Peru
Prior art keywords
cyclopropyl
inhibitors
dioxoimidazolidin
methyl
mmp
Prior art date
Application number
PE2007001670A
Other languages
English (en)
Inventor
David Chapman
Balint Gabos
Magnus Munck
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20081120A1 publication Critical patent/PE20081120A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
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    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
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  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
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  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE HIDANTOINA DE FORMULA (I) DONDE R1 ES H, CH3, CH3CH2, CF3 O CICLOPROPILO; R2 ES H O CH3. SON COMPUESTOS PREFERIDOS: 1-[(4S)-4-CICLOPROPIL-2,5-DIOXOIMIDAZOLIDIN-4-IL]-N-METIL-N-{[4-(PIRIMIDIN-5-ILOXI)FENIL]METIL}METANSULFONAMIDA, 1-[(4S)-4-CICLOPROPIL-2,5-DIOXOIMIDAZOLIDIN-4-IL]-N-[(4-{[2-(TRIFLUOROMETIL)PIRIMIDIN-5-IL]OXI}BENCIL)]METANSULFONAMIDA, 1-[(4S)-4-CICLOPROPIL-2,5-DIOXOIMIDAZOLIDIN-4-IL]-N-({4-[(2-ETILPIRIMIDIN-5-IL)OXI]FENIL}METIL)-N-METILMETANSULFONAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE METALOPROTEINASAS DE MATRIZ 12 (MMP12) O METALOELASTASA SIENDO UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, ASMA, ARTRITIS REUMATOIDE, OSTEOARTRITIS, ESCLEROSIS MULTIPLE
PE2007001670A 2006-11-29 2007-11-28 Derivados de hidantoina como inhibidores de metaloproteinasas de matriz (mmp) PE20081120A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86760606P 2006-11-29 2006-11-29

Publications (1)

Publication Number Publication Date
PE20081120A1 true PE20081120A1 (es) 2008-10-11

Family

ID=38969379

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001670A PE20081120A1 (es) 2006-11-29 2007-11-28 Derivados de hidantoina como inhibidores de metaloproteinasas de matriz (mmp)

Country Status (26)

Country Link
US (2) US8183251B2 (es)
EP (1) EP2097406B1 (es)
JP (1) JP5097212B2 (es)
KR (1) KR20090083416A (es)
CN (1) CN101541789B (es)
AR (1) AR064041A1 (es)
AT (1) ATE517101T1 (es)
AU (1) AU2007327105B2 (es)
BR (1) BRPI0719389A2 (es)
CA (1) CA2670166A1 (es)
CL (1) CL2007003423A1 (es)
CO (1) CO6210692A2 (es)
EC (1) ECSP099370A (es)
ES (1) ES2368013T3 (es)
IL (1) IL198640A0 (es)
MX (1) MX2009005357A (es)
NO (1) NO20092412L (es)
NZ (1) NZ576821A (es)
PE (1) PE20081120A1 (es)
RU (1) RU2463301C2 (es)
SA (1) SA07280646B1 (es)
TW (1) TW200831488A (es)
UA (1) UA93425C2 (es)
UY (1) UY30748A1 (es)
WO (1) WO2008065393A1 (es)
ZA (1) ZA200903286B (es)

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NO20092412L (no) 2009-08-19
CN101541789A (zh) 2009-09-23
ES2368013T3 (es) 2011-11-11
NZ576821A (en) 2011-05-27
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EP2097406A1 (en) 2009-09-09
JP5097212B2 (ja) 2012-12-12
US20080221139A1 (en) 2008-09-11
JP2010511027A (ja) 2010-04-08
RU2463301C2 (ru) 2012-10-10
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MX2009005357A (es) 2009-06-05
BRPI0719389A2 (pt) 2014-10-07
UA93425C2 (ru) 2011-02-10
ZA200903286B (en) 2010-10-27
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IL198640A0 (en) 2010-02-17
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US8183251B2 (en) 2012-05-22
US20120232101A1 (en) 2012-09-13
TW200831488A (en) 2008-08-01
CA2670166A1 (en) 2008-06-05
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AR064041A1 (es) 2009-03-11
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