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PE20081893A1 - Subtipo de amidas selectivas de diazabicicloalcanos - Google Patents

Subtipo de amidas selectivas de diazabicicloalcanos

Info

Publication number
PE20081893A1
PE20081893A1 PE2008000461A PE2008000461A PE20081893A1 PE 20081893 A1 PE20081893 A1 PE 20081893A1 PE 2008000461 A PE2008000461 A PE 2008000461A PE 2008000461 A PE2008000461 A PE 2008000461A PE 20081893 A1 PE20081893 A1 PE 20081893A1
Authority
PE
Peru
Prior art keywords
diazabicycle
heptane
ilcarbonyl
methylfuran
diazabicicloalkanes
Prior art date
Application number
PE2008000461A
Other languages
English (en)
Inventor
Philips S Hammond
Anatoly A Mazurov
Lan Miao
Yun-De Xiao
Balwinder Bhatti
Jon-Paul Strachan
V Srinivasa Murthy
David C Kombo
Srinivasa Rao Akireddy
Original Assignee
Targacept Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Targacept Inc filed Critical Targacept Inc
Publication of PE20081893A1 publication Critical patent/PE20081893A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE DIAZABICICLOALCANOS DE FORMULA (1) A-C(O)-Ci DONDE A ES UN CENTRO DIAZABICICLICO DE 7, 8 O 9 MIEMBROS TALES COMO 2,6-DIAZABICICLO[3.2.0]HEPTANO, 3,7-DIAZABICICLO[4.2.0]OCTANO, 2,7-DIAZABICICLO[3.3.0]OCTANO, ENTRE OTROS; Ci ES UN HETEROARILO TAL COMO 2-FURANILO, 3-TIENILO, 2-OXAZOLILO, 1,3,4-OXADIAZOL-2-IL, 3-PIRIDINIL, ENTRE OTROS, OPCIONALMENTE SUSTITUIDOS CON HALOGENO, CN, NO2, N3, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: 6-(FURAN-2-ILCARBONIL)-2,6-DIAZABICICLO[3.2.0]HEPTANO, 2-(3-METILFURAN-2-ILCARBONIL)-2,6-DIAZABICICLO[3.2.0]HEPTANO, 6-(3-METILFURAN-2-ILCARBONIL)-2,6-DIAZABICICLO[3.2.0]HEPTANO, 2-(5-METILFURAN-2-ILCARBONIL)-2,6-DIAZABICICLO[3.2.0]HEPTANO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE RECEPTORES DE ACETILCOLINA NICOTINICOS NEURONALES SIENDO UTILES EN EL TRATAMIENTO DE DEMENCIA SENIL, ESQUIZOFRENIA, DISLEXIA
PE2008000461A 2007-03-13 2008-03-12 Subtipo de amidas selectivas de diazabicicloalcanos PE20081893A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90676207P 2007-03-13 2007-03-13

Publications (1)

Publication Number Publication Date
PE20081893A1 true PE20081893A1 (es) 2009-02-15

Family

ID=39580235

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008000461A PE20081893A1 (es) 2007-03-13 2008-03-12 Subtipo de amidas selectivas de diazabicicloalcanos

Country Status (7)

Country Link
US (1) US20100144700A1 (es)
AR (1) AR065705A1 (es)
CL (1) CL2008000726A1 (es)
PE (1) PE20081893A1 (es)
TW (1) TW200840569A (es)
UY (1) UY30959A1 (es)
WO (1) WO2008112734A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010028033A1 (en) * 2008-09-05 2010-03-11 Targacept, Inc. Amides of diazabicyclooctanes and uses thereof
AU2010262643B2 (en) * 2009-06-19 2015-02-19 Abbvie Inc. Diazahomoadamantane derivatives and methods of use thereof
CN102648202A (zh) * 2009-12-07 2012-08-22 塔加西普特公司 作为神经元烟碱乙酰胆碱受体配体的3,6-二氮杂双环[3.1.1]庚烷
EP3154974B1 (en) * 2014-06-13 2018-11-14 Bristol-Myers Squibb Company Tricyclic compounds as alpha- 7 nicotinic acetylcholine receptor ligands
CA2997545C (en) * 2015-09-04 2022-01-11 Janssen Pharmaceutica Nv Therapeutic compounds for pain and synthesis thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135484B2 (en) * 2002-08-14 2006-11-14 Abbott Laboratories Azabicyclic compounds are central nervous system active agents
US7399765B2 (en) * 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
EP1697378B1 (en) * 2003-12-22 2007-11-21 Memory Pharmaceuticals Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
CN101248073A (zh) * 2005-08-22 2008-08-20 塔加西普特公司 杂芳基-取代的二氮杂三环烷类、其制备方法及其应用

Also Published As

Publication number Publication date
CL2008000726A1 (es) 2008-06-06
US20100144700A1 (en) 2010-06-10
WO2008112734A1 (en) 2008-09-18
AR065705A1 (es) 2009-06-24
TW200840569A (en) 2008-10-16
UY30959A1 (es) 2009-09-30

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Legal Events

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