PE20081701A1 - Derivados de pirrolopiridina-2-carboxamidas y su preparacion - Google Patents
Derivados de pirrolopiridina-2-carboxamidas y su preparacionInfo
- Publication number
- PE20081701A1 PE20081701A1 PE2008000152A PE2008000152A PE20081701A1 PE 20081701 A1 PE20081701 A1 PE 20081701A1 PE 2008000152 A PE2008000152 A PE 2008000152A PE 2008000152 A PE2008000152 A PE 2008000152A PE 20081701 A1 PE20081701 A1 PE 20081701A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- pyrrolo
- carboxamide
- pyridin
- pyridyl
- Prior art date
Links
- -1 PYRROLOPYRIDINE COMPOUND Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- AUKFDIFLZGXBKD-UHFFFAOYSA-N 1-(pyridin-4-ylmethyl)pyrrolo[2,3-b]pyridine-2-carboxamide Chemical compound N1=CC=C(C=C1)CN1C(=CC=2C1=NC=CC=2)C(=O)N AUKFDIFLZGXBKD-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 102000003566 TRPV1 Human genes 0.000 abstract 1
- 101150016206 Trpv1 gene Proteins 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
REFERIDA A UN COMPUESTO DE PIRROLOPIRIDINA DE FORMULA (I), DONDE n ES UN ENTERO DE 0 A 3; X ES HALOGENO, ALQUILO C1-C6, CICLOALQUILO C3-C7, C(O)NR1R2, ENTRE OTROS; Y ES UN GRUPO HETEROARILO OPCIONALMENTE SUSTITUIDO CON CICLOALQUILO C3-C7, FLUOROALCOXILO C1-C6, NITRO, HIDROXILO, NR1R2, ENTRE OTROS; R1 Y R2 SON H, ALQUILO C1-C6, ARILALQUILENO C1-C5, ENTRE OTROS; W ES UN GRUPO BICICLICO CONDENSADO DE FORMULA (a), DONDE A ES UN HETEROCICLO DE 5 A 7 ESLABONES QUE COMPRENDE HETEROATOMOS TALES COMO O, N O S, OPCIONALMENTE SUSTITUIDO POR UNO O VARIOS H, ALQUILO C1-C6, FLUOROALQUILO C1-C6, OXO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(2-METIL-BENZOTIAZOL-5-IL)-5-FLUORO-1[(4-PIRIDIL)METIL]-1H-PIRROLO[2,3-b]PIRIDIN-2-CARBOXAMIDA, N-(1,2-DIMETIL-1H-BENCIMIDAZOL-5-IL)-5-FLUORO-1-[(4-PIRIDIL)METIL]-1H-PIRROLO[2,3-b]PIRIDIN-2-CARBOXAMIDA, N-(2-METIL-BENZOTIAZOL-5-IL)-1-(3-PIRIDIL)-1H-PIRROLO[2,3-b]PIRIDIN-2-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES TRPV1 (VR1) Y SON UTILES EN EL TRATAMIENTO DEL DOLOR, INFLAMACION, DOLOR NEUROPATICO, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0700356A FR2911605B1 (fr) | 2007-01-19 | 2007-01-19 | Derives de pyrrolopyridine-2-carbowamides, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081701A1 true PE20081701A1 (es) | 2008-12-31 |
Family
ID=38457983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000152A PE20081701A1 (es) | 2007-01-19 | 2008-01-17 | Derivados de pirrolopiridina-2-carboxamidas y su preparacion |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8044066B2 (es) |
| EP (1) | EP2106401B1 (es) |
| JP (1) | JP5264772B2 (es) |
| AR (1) | AR064936A1 (es) |
| AT (1) | ATE549339T1 (es) |
| CL (1) | CL2008000128A1 (es) |
| CY (1) | CY1112855T1 (es) |
| DK (1) | DK2106401T3 (es) |
| ES (1) | ES2384289T3 (es) |
| FR (1) | FR2911605B1 (es) |
| HR (1) | HRP20120496T1 (es) |
| PE (1) | PE20081701A1 (es) |
| PL (1) | PL2106401T3 (es) |
| PT (1) | PT2106401E (es) |
| SI (1) | SI2106401T1 (es) |
| TW (1) | TW200836726A (es) |
| UY (1) | UY30875A1 (es) |
| WO (1) | WO2008107543A2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926554B1 (fr) | 2008-01-22 | 2010-03-12 | Sanofi Aventis | Derives de carboxamides azabicycliques, leur preparation et leur application en therapeutique |
| FR2926556B1 (fr) * | 2008-01-22 | 2010-02-19 | Sanofi Aventis | Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique |
| TWI501967B (zh) * | 2010-12-16 | 2015-10-01 | Janssen R&D Ireland | 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類 |
| US20210253772A1 (en) | 2020-02-18 | 2021-08-19 | Covestro Llc | Polyoxazolidinone compositions |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1463714A4 (en) | 2001-12-10 | 2005-10-19 | Amgen Inc | VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS |
| ES2316777T3 (es) | 2002-02-15 | 2009-04-16 | Glaxo Group Limited | Moduladores de receptores vainilloides. |
| NZ543482A (en) | 2003-05-21 | 2009-02-28 | Prosidion Ltd | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phoshorylase |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| GB0403819D0 (en) * | 2004-02-20 | 2004-03-24 | Merck Sharp & Dohme | New compounds |
| WO2006059163A1 (en) | 2004-12-02 | 2006-06-08 | Prosidion Limited | Treatment of diabetes with glycogen phosphorylase inhibitors |
| JP2008530250A (ja) | 2005-02-17 | 2008-08-07 | メルク エンド カムパニー インコーポレーテッド | アテローム性動脈硬化症、脂質代謝異常及び関連症状の治療方法 |
| FR2888847B1 (fr) * | 2005-07-22 | 2007-08-31 | Sanofi Aventis Sa | Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique |
| FR2888848B1 (fr) * | 2005-07-22 | 2007-09-28 | Sanofi Aventis Sa | Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2897061B1 (fr) * | 2006-02-03 | 2010-09-03 | Sanofi Aventis | Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique. |
-
2007
- 2007-01-19 FR FR0700356A patent/FR2911605B1/fr not_active Expired - Fee Related
-
2008
- 2008-01-16 CL CL200800128A patent/CL2008000128A1/es unknown
- 2008-01-17 HR HRP20120496AT patent/HRP20120496T1/hr unknown
- 2008-01-17 SI SI200830653T patent/SI2106401T1/sl unknown
- 2008-01-17 AR ARP080100205A patent/AR064936A1/es not_active Application Discontinuation
- 2008-01-17 PT PT08761773T patent/PT2106401E/pt unknown
- 2008-01-17 DK DK08761773.4T patent/DK2106401T3/da active
- 2008-01-17 EP EP08761773A patent/EP2106401B1/fr not_active Not-in-force
- 2008-01-17 TW TW097101844A patent/TW200836726A/zh unknown
- 2008-01-17 PE PE2008000152A patent/PE20081701A1/es not_active Application Discontinuation
- 2008-01-17 ES ES08761773T patent/ES2384289T3/es active Active
- 2008-01-17 WO PCT/FR2008/000054 patent/WO2008107543A2/fr not_active Ceased
- 2008-01-17 JP JP2009545974A patent/JP5264772B2/ja not_active Expired - Fee Related
- 2008-01-17 PL PL08761773T patent/PL2106401T3/pl unknown
- 2008-01-17 AT AT08761773T patent/ATE549339T1/de active
- 2008-01-18 UY UY30875A patent/UY30875A1/es unknown
-
2009
- 2009-07-17 US US12/504,770 patent/US8044066B2/en not_active Expired - Fee Related
-
2012
- 2012-06-11 CY CY20121100526T patent/CY1112855T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5264772B2 (ja) | 2013-08-14 |
| WO2008107543A3 (fr) | 2008-12-24 |
| UY30875A1 (es) | 2008-09-02 |
| ATE549339T1 (de) | 2012-03-15 |
| FR2911605A1 (fr) | 2008-07-25 |
| WO2008107543A2 (fr) | 2008-09-12 |
| CL2008000128A1 (es) | 2008-05-23 |
| TW200836726A (en) | 2008-09-16 |
| CY1112855T1 (el) | 2016-02-10 |
| AR064936A1 (es) | 2009-05-06 |
| DK2106401T3 (da) | 2012-07-02 |
| SI2106401T1 (sl) | 2012-07-31 |
| ES2384289T3 (es) | 2012-07-03 |
| US20090298865A1 (en) | 2009-12-03 |
| JP2010516661A (ja) | 2010-05-20 |
| US8044066B2 (en) | 2011-10-25 |
| PT2106401E (pt) | 2012-06-18 |
| HRP20120496T1 (hr) | 2012-07-31 |
| EP2106401B1 (fr) | 2012-03-14 |
| PL2106401T3 (pl) | 2012-08-31 |
| EP2106401A2 (fr) | 2009-10-07 |
| FR2911605B1 (fr) | 2009-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |