PE20081511A1 - PIPERIDINE-DERIVED COMPOUNDS AS ANTIBACTERIALS - Google Patents
PIPERIDINE-DERIVED COMPOUNDS AS ANTIBACTERIALSInfo
- Publication number
- PE20081511A1 PE20081511A1 PE2007001798A PE2007001798A PE20081511A1 PE 20081511 A1 PE20081511 A1 PE 20081511A1 PE 2007001798 A PE2007001798 A PE 2007001798A PE 2007001798 A PE2007001798 A PE 2007001798A PE 20081511 A1 PE20081511 A1 PE 20081511A1
- Authority
- PE
- Peru
- Prior art keywords
- cyane
- halo
- oxo
- alkyl
- dihydroquinolin
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 208000006374 Uterine Cervicitis Diseases 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 206010008323 cervicitis Diseases 0.000 abstract 1
- 206010014665 endocarditis Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 208000000143 urethritis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE PIPERIDINA DE FOMULA (I), DONDE A ES CH y N; D ES C-R7 y N; E ES O, NH Y S; G ES O Y S; J ES C-R4 Y N; R1 ES H, HALO, CIANO, ALQUILO C1-C6, ENTRE OTROS; R2 ES HALO, CIANO, ALQUILO C1-C6, ENTRE OTROS; R3 ES H, HALO, CIANO, ALQUILO C1-C6, ENTRE OTROS; R4 ES H, HALO, CIANO, ENTRE OTROS; R7 ES H, HALO, ALQUILO C1-C6, CIANO, ENTRE OTROS; R8 Y R9 SON H o R8 Y R9 JUNTOS FORMAN =O; Y DONDE EL CARBONO "a" Y EL CARBONO "b" SE ENCUENTRAN EN RELACION (+) ,RELACION CIS (-), RELACION TRANS (+) O TRANS (-) ENTRE SI. SON COMPUESTOS PREFERIDOS: SAL DICLORHIDRATO DE 1-(2-{(3R,4S)-4-[(2,3-DIHIDRO[1,4]DIOXINO[2,3-c]PIRIDIN-7-ILMETIL)AMINO]-3-HIDROXIPIPERIDIN-1-IL}ETIL)-2-OXO-1,2-DIHIDROQUINOLIN-7-CARBONITRILO, SAL CLORHIDRATO DE 1-[2-((3R,4R)-3-HIDROXI-4-{[(3-OXO-3,4-DIHIDRO-2H-PIRIDO[3,2-b][1,4]OXAZIN-6-IL)METIL]AMINO}PIPERIDIN-1-IL)ETIL]-2-OXO-1,2-DIHIDROQUINOLIN-7-CARBONITRILO, SAL DICLORHIDRATO DE 1-[2-((3R,4S)-3-HIDROXI-4-{[(3-OXO-3,4-DIHIDRO-2H-PIRIDO[3,2-b][1,4]TIAZIN-6-IL)METIL]AMINO}PIPERIDIN-1-IL)ETIL]-2-OXO-1,2-DIHIDROQUINOLIN-7-CARBONITRILO, ENTRE OTROS. DICHOS COMPUESTOS SON ANTIBACTERIANOS UTILES EN EL TRATAMIENTO DE INFECCIONES TAL COMO BRONQUITIS, CERVICITIS, ENDOCARDITIS, URETRITIS GONOCOCCICA, ENTRE OTRASREFERRING TO A COMPOUND DERIVED FROM PIPERIDINE OF FOMULA (I), WHERE A IS CH and N; D IS C-R7 and N; E IS O, NH Y S; G IS O Y S; J IS C-R4 Y N; R1 IS H, HALO, CYANE, C1-C6 ALKYL, AMONG OTHERS; R2 IS HALO, CYANE, C1-C6 ALKYL, AMONG OTHERS; R3 IS H, HALO, CYANE, C1-C6 ALKYL, AMONG OTHERS; R4 IS H, HALO, CYANE, AMONG OTHERS; R7 IS H, HALO, C1-C6 ALKYL, CYANE, AMONG OTHERS; R8 AND R9 ARE H or R8 AND R9 TOGETHER FORM = O; AND WHERE THE CARBON "a" AND THE CARBON "b" ARE IN RELATION (+), RELATION CIS (-), RELATION TRANS (+) OR TRANS (-) WITH EACH OTHER. PREFERRED COMPOUNDS ARE: 1- (2 - {(3R, 4S) -4 - [(2,3-DIHYDRO [1,4] DIOXINO [2,3-c] PYRIDIN-7-ILMETYL) AMINO DICHLORHYDRATE SALT] - 3-HYDROXIPIPERIDIN-1-IL} ETHYL) -2-OXO-1,2-DIHYDROQUINOLIN-7-CARBONITRILE, SALT 1- [2 - ((3R, 4R) -3-HYDROXY-4 - {[(3 -OXO-3,4-DIHYDRO-2H-PYRIDO [3,2-b] [1,4] OXAZIN-6-IL) METHYL] AMINO} PIPERIDIN-1-IL) ETHYL] -2-OXO-1,2 -DIHYDROQUINOLIN-7-CARBONITRILE, SALT DICHLORHYDRATE OF 1- [2 - ((3R, 4S) -3-HYDROXY-4 - {[(3-OXO-3,4-DIHYDRO-2H-PYRIDE [3,2-b ] [1,4] THIAZIN-6-IL) METHYL] AMINO} PIPERIDIN-1-IL) ETHYL] -2-OXO-1,2-DIHYDROQUINOLIN-7-CARBONITRILE, AMONG OTHERS. SUCH COMPOUNDS ARE USEFUL ANTIBACTERIAL IN THE TREATMENT OF INFECTIONS SUCH AS BRONCHITIS, CERVICITIS, ENDOCARDITIS, GONOCOCCICA URETHRITIS, AMONG OTHERS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87018106P | 2006-12-15 | 2006-12-15 | |
| US96916307P | 2007-08-30 | 2007-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081511A1 true PE20081511A1 (en) | 2008-12-12 |
Family
ID=39046831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001798A PE20081511A1 (en) | 2006-12-15 | 2007-12-14 | PIPERIDINE-DERIVED COMPOUNDS AS ANTIBACTERIALS |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP2121702A1 (en) |
| JP (1) | JP2010513255A (en) |
| KR (1) | KR20090090385A (en) |
| AR (1) | AR064369A1 (en) |
| AU (1) | AU2007331247B2 (en) |
| BR (1) | BRPI0720236A2 (en) |
| CA (1) | CA2671485A1 (en) |
| CL (1) | CL2007003641A1 (en) |
| CO (1) | CO6190619A2 (en) |
| EC (1) | ECSP099506A (en) |
| MX (1) | MX2009006325A (en) |
| NO (1) | NO20092655L (en) |
| PE (1) | PE20081511A1 (en) |
| RU (1) | RU2009126731A (en) |
| TW (1) | TW200831517A (en) |
| UY (1) | UY30788A1 (en) |
| WO (1) | WO2008071961A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY150958A (en) | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| US8329694B2 (en) | 2005-06-24 | 2012-12-11 | Toyama Chemical Co., Ltd. | Quinoxalinones as antibacterial composition |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| KR101667066B1 (en) | 2008-10-10 | 2016-10-17 | 액테리온 파마슈티칼 리미티드 | Oxazolininyl antibiotics |
| AR076222A1 (en) | 2009-04-09 | 2011-05-26 | Actelion Pharmaceuticals Ltd | DERIVATIVES 2-HYDROXIETIL-1H-QUINOLIN-ONA AND ITS AZAISOTHERAL ANALOGS WITH ANTIBACTERIAL ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| US20130259899A1 (en) * | 2010-10-04 | 2013-10-03 | Allen-Vercoe, Emma Molecular And Cellular Biology University Of Guelph | Detection of fusobacterium in a gastrointestinal sample to diagnose gastrointestinal cancer |
| US11440884B2 (en) * | 2017-08-21 | 2022-09-13 | Acadia Pharmaceuticals Inc. | Compounds, salts thereof and methods for treatment of diseases |
| WO2019040107A1 (en) | 2017-08-21 | 2019-02-28 | Acadia Pharmaceuticals Inc. | Compounds, salts thereof and methods for treatment of diseases |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19601265A1 (en) * | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-oxo and 2-thio-1,2-dihydroquinolinyl oxazolidinones |
| TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
| JP5314244B2 (en) * | 2004-10-27 | 2013-10-16 | 富山化学工業株式会社 | Novel nitrogen-containing heterocyclic compounds and salts thereof |
| MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| US8329694B2 (en) * | 2005-06-24 | 2012-12-11 | Toyama Chemical Co., Ltd. | Quinoxalinones as antibacterial composition |
| AU2007268749B2 (en) * | 2006-05-26 | 2012-07-26 | Taisho Pharmaceutical Co., Ltd. | Novel heterocyclic compound or salt thereof and intermediate thereof |
| US20100256124A1 (en) * | 2006-06-09 | 2010-10-07 | David Thomas Davies | Substituted 1-Methyl-1H-Quinolin-2-Ones And 1-Methyl-1H-1,5-Naphthyridin-2-Ones As Antibacterials |
| GB0613208D0 (en) * | 2006-07-03 | 2006-08-09 | Glaxo Group Ltd | Compounds |
| EP1992628A1 (en) * | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| JP5315239B2 (en) * | 2006-07-20 | 2013-10-16 | グラクソ グループ リミテッド | N-ethylquinolone and derivatives and analogs of N-ethylazaquinolone |
-
2007
- 2007-12-12 TW TW096147437A patent/TW200831517A/en unknown
- 2007-12-13 WO PCT/GB2007/004766 patent/WO2008071961A1/en not_active Ceased
- 2007-12-13 KR KR1020097014660A patent/KR20090090385A/en not_active Withdrawn
- 2007-12-13 MX MX2009006325A patent/MX2009006325A/en not_active Application Discontinuation
- 2007-12-13 UY UY30788A patent/UY30788A1/en unknown
- 2007-12-13 AU AU2007331247A patent/AU2007331247B2/en not_active Expired - Fee Related
- 2007-12-13 RU RU2009126731/04A patent/RU2009126731A/en not_active Application Discontinuation
- 2007-12-13 EP EP07848510A patent/EP2121702A1/en not_active Withdrawn
- 2007-12-13 BR BRPI0720236-9A2A patent/BRPI0720236A2/en not_active IP Right Cessation
- 2007-12-13 JP JP2009540854A patent/JP2010513255A/en active Pending
- 2007-12-13 CA CA002671485A patent/CA2671485A1/en not_active Abandoned
- 2007-12-14 CL CL200703641A patent/CL2007003641A1/en unknown
- 2007-12-14 PE PE2007001798A patent/PE20081511A1/en not_active Application Discontinuation
- 2007-12-14 AR ARP070105641A patent/AR064369A1/en not_active Application Discontinuation
-
2009
- 2009-07-02 CO CO09068489A patent/CO6190619A2/en not_active Application Discontinuation
- 2009-07-09 EC EC2009009506A patent/ECSP099506A/en unknown
- 2009-07-13 NO NO20092655A patent/NO20092655L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2671485A1 (en) | 2008-06-19 |
| TW200831517A (en) | 2008-08-01 |
| JP2010513255A (en) | 2010-04-30 |
| UY30788A1 (en) | 2008-07-31 |
| MX2009006325A (en) | 2009-07-24 |
| NO20092655L (en) | 2009-09-02 |
| EP2121702A1 (en) | 2009-11-25 |
| WO2008071961A8 (en) | 2009-10-22 |
| CO6190619A2 (en) | 2010-08-19 |
| RU2009126731A (en) | 2011-01-20 |
| BRPI0720236A2 (en) | 2013-12-24 |
| WO2008071961A1 (en) | 2008-06-19 |
| AR064369A1 (en) | 2009-04-01 |
| KR20090090385A (en) | 2009-08-25 |
| AU2007331247A1 (en) | 2008-06-19 |
| CL2007003641A1 (en) | 2008-09-22 |
| ECSP099506A (en) | 2009-08-28 |
| AU2007331247B2 (en) | 2011-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |