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PE20080342A1 - Inhibidores de proteasa de hiv de 2-(amino-sustituido)-benzotiazol sulfonamida - Google Patents

Inhibidores de proteasa de hiv de 2-(amino-sustituido)-benzotiazol sulfonamida

Info

Publication number
PE20080342A1
PE20080342A1 PE2007000802A PE2007000802A PE20080342A1 PE 20080342 A1 PE20080342 A1 PE 20080342A1 PE 2007000802 A PE2007000802 A PE 2007000802A PE 2007000802 A PE2007000802 A PE 2007000802A PE 20080342 A1 PE20080342 A1 PE 20080342A1
Authority
PE
Peru
Prior art keywords
amino
protease inhibitors
hiv protease
substituted
benzothiazole sulfonamide
Prior art date
Application number
PE2007000802A
Other languages
English (en)
Inventor
Kock Herman Augustinus De
Tim Hugo Maria Jonckers
Paul Jozef Gabriel Maria Boonants
Stefaan Julien Last
Inge Dierynck
T Klooster Gerben Albert Van
Judith Eva Baumeister
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of PE20080342A1 publication Critical patent/PE20080342A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R ES UN ANILLO PIPERIDINA, PIRROLIDINA SUSTITUIDO O NO EN UNO O MAS DE LOS MIEMBROS DE ANILLO, CON ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS. UN COMPUESTO PREFERIDO ES HEXAHIDRO-FURO[2,3-b]FURAN-3-IL-ESTER DE ACIDO (1-BENCIL-3-{[2-(1-CICLOPENTIL-PIPERIDIN-4-ILAMINO)-BENZOTIAZOL-6-SULFONIL]-ISOBUTIL-AMINO}-2-HIDROXI-PROPIL)-CARBAMICO. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEASA DE HIV DE AMPLIO ESPECTRO UTILES EN EL TRATAMIENTO DE INFECCION DE RETROVIRUS RESISTENTE A MULTIPLES FARMACOS
PE2007000802A 2006-06-23 2007-06-22 Inhibidores de proteasa de hiv de 2-(amino-sustituido)-benzotiazol sulfonamida PE20080342A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06116003 2006-06-23

Publications (1)

Publication Number Publication Date
PE20080342A1 true PE20080342A1 (es) 2008-04-25

Family

ID=37596252

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000802A PE20080342A1 (es) 2006-06-23 2007-06-22 Inhibidores de proteasa de hiv de 2-(amino-sustituido)-benzotiazol sulfonamida

Country Status (30)

Country Link
US (1) US8202887B2 (es)
EP (1) EP2035432B1 (es)
JP (1) JP5232776B2 (es)
KR (1) KR101419320B1 (es)
CN (1) CN101479275B (es)
AP (1) AP2069A (es)
AR (1) AR061619A1 (es)
AT (1) ATE544769T1 (es)
AU (1) AU2007262943B2 (es)
BR (1) BRPI0713487B1 (es)
CA (1) CA2653233C (es)
CL (1) CL2007001826A1 (es)
CY (1) CY1112971T1 (es)
DK (1) DK2035432T3 (es)
EA (1) EA016387B1 (es)
ES (1) ES2381129T3 (es)
IL (1) IL195381A (es)
JO (1) JO2841B1 (es)
MX (1) MX2009000160A (es)
MY (1) MY146805A (es)
NZ (1) NZ573286A (es)
PE (1) PE20080342A1 (es)
PL (1) PL2035432T3 (es)
PT (1) PT2035432E (es)
SI (1) SI2035432T1 (es)
TW (1) TWI415851B (es)
UA (1) UA96445C2 (es)
UY (1) UY30416A1 (es)
WO (1) WO2007147884A1 (es)
ZA (1) ZA200810350B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3090B1 (ar) 2009-12-11 2017-03-15 Janssen Sciences Ireland Uc 5- امينو-4- هيدروكسي-بنتويل اميدات
US9102614B2 (en) 2010-07-02 2015-08-11 Gilead Sciences, Inc. Naphth-2-ylacetic acid derivatives to treat AIDS
PH12013500015A1 (en) 2010-07-02 2013-02-18 Gilead Sciences Inc 2 -quinolinyl- acetic acid derivatives as hiv antiviral compounds
US9024038B2 (en) * 2010-12-27 2015-05-05 Purdue Research Foundation Compunds and methods for treating HIV
EA024952B1 (ru) * 2011-04-21 2016-11-30 Джилид Сайэнс, Инк. Бензотиазолы и их применение для лечения вич-инфекции
US9376392B2 (en) 2012-01-04 2016-06-28 Gilead Sciences, Inc. 2-(tert-butoxy)-2-(7-methylquinolin-6-yl) acetic acid derivatives for treating AIDS
US9284323B2 (en) 2012-01-04 2016-03-15 Gilead Sciences, Inc. Naphthalene acetic acid derivatives against HIV infection
RU2014115227A (ru) 2012-04-20 2015-10-27 Джилид Сайэнс, Инк. Производные бензотиазол-6-ил уксусной кислоты и их примение для лечения вич-инфекции
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
US12083099B2 (en) 2020-10-28 2024-09-10 Accencio LLC Methods of treating symptoms of coronavirus infection with viral protease inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002302363B2 (en) * 2001-02-14 2008-05-01 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors
AR037797A1 (es) * 2001-12-12 2004-12-01 Tibotec Pharm Ltd Combinacion de inhibidores de proteasa dependientes del citocromo p450
WO2004014371A1 (en) * 2002-08-02 2004-02-19 Tibotec Pharmaceuticals Ltd. Broadspectrum 2-amino-benzothiazole sulfonamide hiv protease inhibitors
US20080234288A1 (en) * 2003-09-30 2008-09-25 Kenneth Alan Simmen Hcv Inhibiting Sulfonamides

Also Published As

Publication number Publication date
JP5232776B2 (ja) 2013-07-10
JO2841B1 (en) 2014-09-15
BRPI0713487A2 (es) 2012-11-13
PL2035432T3 (pl) 2012-07-31
UA96445C2 (ru) 2011-11-10
NZ573286A (en) 2011-09-30
CN101479275A (zh) 2009-07-08
BRPI0713487A8 (pt) 2018-01-02
TWI415851B (zh) 2013-11-21
BRPI0713487B1 (pt) 2022-07-26
KR20090024257A (ko) 2009-03-06
AU2007262943A1 (en) 2007-12-27
ZA200810350B (en) 2010-05-26
KR101419320B1 (ko) 2014-07-14
PT2035432E (pt) 2012-04-24
ATE544769T1 (de) 2012-02-15
CL2007001826A1 (es) 2008-01-18
AR061619A1 (es) 2008-09-10
EA200970052A1 (ru) 2009-04-28
ES2381129T3 (es) 2012-05-23
US8202887B2 (en) 2012-06-19
CA2653233C (en) 2015-09-29
AP2008004679A0 (en) 2008-12-31
SI2035432T1 (sl) 2012-06-29
TW200817416A (en) 2008-04-16
DK2035432T3 (da) 2012-05-14
MX2009000160A (es) 2009-01-23
EP2035432B1 (en) 2012-02-08
IL195381A (en) 2013-01-31
AP2069A (en) 2009-12-08
HK1125633A1 (en) 2009-08-14
JP2009541272A (ja) 2009-11-26
UY30416A1 (es) 2008-01-31
CY1112971T1 (el) 2016-04-13
IL195381A0 (en) 2009-08-03
US20090209583A1 (en) 2009-08-20
AU2007262943B2 (en) 2012-04-12
CA2653233A1 (en) 2007-12-27
CN101479275B (zh) 2012-03-07
MY146805A (en) 2012-09-28
EA016387B1 (ru) 2012-04-30
WO2007147884A1 (en) 2007-12-27
EP2035432A1 (en) 2009-03-18

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