PE20080707A1 - Derivados de benzoxazol y benzotiazol como ligandos de 5-hidroxitriptamina-6 - Google Patents
Derivados de benzoxazol y benzotiazol como ligandos de 5-hidroxitriptamina-6Info
- Publication number
- PE20080707A1 PE20080707A1 PE2007000635A PE2007000635A PE20080707A1 PE 20080707 A1 PE20080707 A1 PE 20080707A1 PE 2007000635 A PE2007000635 A PE 2007000635A PE 2007000635 A PE2007000635 A PE 2007000635A PE 20080707 A1 PE20080707 A1 PE 20080707A1
- Authority
- PE
- Peru
- Prior art keywords
- hydroxitriptamine
- benzoxazole
- binders
- naftilsulfonil
- benzoxazol
- Prior art date
Links
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical compound C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 title abstract 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title abstract 2
- 239000011230 binding agent Substances 0.000 title 1
- 108091005435 5-HT6 receptors Proteins 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 231100000863 loss of memory Toxicity 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A COMPUESTOS BENZOXAZOL Y BENZOTIAZOL DE FORMULA (I), EN DONDE X ES O o SOn; n ES O,1 o 2; R1 ES ARILO, HETEROARILO O UN SISTEMA BI O TRICICLICO, OPCIONALMENTE SUSTITUIDOS; R2 ES H, ALQUILO, ENTRE OTROS; R3 y R4 SON INDEPENDIENTEMENTE H, ALQUILO, ENTRE OTROS; R5 ES H, HALOGENO, NR6R7, ENTRE OTROS. SON SELECCIONADOS: 4-(1-NAFTILSULFONIL)-2-PIPERAZIN-1-IL-1,3-BENZOXAZOL, 7-(1-NAFTILSULFONIL)-2-PIPERAZIN-1-IL-1,3-BENZOXAZOL, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MODULADORES DEL RECEPTOR 5-HIDROXITRIPTAMINA-6 (5-HT6) Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVISOSO CENTRAL RELACIONADOS O AFECTADOS POR EL RECEPTOR 5-HT6, COMO LA ENFERMEDAD DE PARKINSON, ALZHEIMER, TRASTORNO DEL SUENO, PERDIDA DE LA MEMORIA, ESQUIZOFRENIA Y RELACIONADOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80999606P | 2006-06-01 | 2006-06-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20080707A1 true PE20080707A1 (es) | 2008-05-22 |
Family
ID=38668755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007000635A PE20080707A1 (es) | 2006-06-01 | 2007-05-23 | Derivados de benzoxazol y benzotiazol como ligandos de 5-hidroxitriptamina-6 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7501421B2 (es) |
| EP (1) | EP2024348A2 (es) |
| JP (1) | JP2009538909A (es) |
| KR (1) | KR20090023641A (es) |
| CN (1) | CN101490022A (es) |
| AR (1) | AR061147A1 (es) |
| AU (1) | AU2007255041A1 (es) |
| BR (1) | BRPI0712444A2 (es) |
| CA (1) | CA2659701A1 (es) |
| CR (1) | CR10474A (es) |
| EC (1) | ECSP088930A (es) |
| IL (1) | IL195590A0 (es) |
| MX (1) | MX2008015328A (es) |
| NO (1) | NO20085045L (es) |
| PE (1) | PE20080707A1 (es) |
| TW (1) | TW200804310A (es) |
| WO (1) | WO2007142904A2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201401169QA (en) * | 2009-04-02 | 2014-05-29 | Merck Serono Sa | Dihydroorotate dehydrogenase inhibitors |
| KR101250606B1 (ko) * | 2011-01-24 | 2013-04-03 | 이화여자대학교 산학협력단 | 5-ｈｔ６ 수용체 억제 작용을 갖는 신규한 벤조티아졸 및 벤즈이소티아졸유도체, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
| EP3020718B1 (en) * | 2013-07-10 | 2018-12-26 | Meiji Seika Pharma Co., Ltd. | Novel pde4 inhibitor |
| JP6515175B2 (ja) | 2014-07-08 | 2019-05-15 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． | 芳香族ヘテロ環誘導体及びその医薬的適用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7582635B2 (en) * | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| GB0422263D0 (en) * | 2004-10-07 | 2004-11-10 | Glaxo Group Ltd | Novel compounds |
-
2007
- 2007-05-23 PE PE2007000635A patent/PE20080707A1/es not_active Application Discontinuation
- 2007-05-25 CN CNA2007800261442A patent/CN101490022A/zh active Pending
- 2007-05-25 CA CA002659701A patent/CA2659701A1/en not_active Abandoned
- 2007-05-25 AU AU2007255041A patent/AU2007255041A1/en not_active Abandoned
- 2007-05-25 MX MX2008015328A patent/MX2008015328A/es not_active Application Discontinuation
- 2007-05-25 JP JP2009513221A patent/JP2009538909A/ja not_active Withdrawn
- 2007-05-25 EP EP07777299A patent/EP2024348A2/en not_active Withdrawn
- 2007-05-25 WO PCT/US2007/012569 patent/WO2007142904A2/en not_active Ceased
- 2007-05-25 TW TW096118646A patent/TW200804310A/zh unknown
- 2007-05-25 KR KR1020087031621A patent/KR20090023641A/ko not_active Withdrawn
- 2007-05-25 BR BRPI0712444-9A patent/BRPI0712444A2/pt not_active Application Discontinuation
- 2007-05-31 AR ARP070102364A patent/AR061147A1/es unknown
- 2007-05-31 US US11/809,424 patent/US7501421B2/en not_active Expired - Fee Related
-
2008
- 2008-11-27 IL IL195590A patent/IL195590A0/en unknown
- 2008-12-01 CR CR10474A patent/CR10474A/es not_active Application Discontinuation
- 2008-12-01 EC EC2008008930A patent/ECSP088930A/es unknown
- 2008-12-03 NO NO20085045A patent/NO20085045L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20070281945A1 (en) | 2007-12-06 |
| AU2007255041A1 (en) | 2007-12-13 |
| BRPI0712444A2 (pt) | 2012-06-05 |
| US7501421B2 (en) | 2009-03-10 |
| WO2007142904A2 (en) | 2007-12-13 |
| CA2659701A1 (en) | 2007-12-13 |
| CR10474A (es) | 2009-01-07 |
| ECSP088930A (es) | 2009-01-30 |
| JP2009538909A (ja) | 2009-11-12 |
| EP2024348A2 (en) | 2009-02-18 |
| IL195590A0 (en) | 2009-09-01 |
| WO2007142904A3 (en) | 2008-02-07 |
| AR061147A1 (es) | 2008-08-06 |
| MX2008015328A (es) | 2008-12-12 |
| KR20090023641A (ko) | 2009-03-05 |
| TW200804310A (en) | 2008-01-16 |
| CN101490022A (zh) | 2009-07-22 |
| NO20085045L (no) | 2008-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |