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PE20071311A1 - Compuestos 8-azabiciclo[3.2.1]octano como antagonistas del receptor opioide mu - Google Patents

Compuestos 8-azabiciclo[3.2.1]octano como antagonistas del receptor opioide mu

Info

Publication number
PE20071311A1
PE20071311A1 PE2007000212A PE2007000212A PE20071311A1 PE 20071311 A1 PE20071311 A1 PE 20071311A1 PE 2007000212 A PE2007000212 A PE 2007000212A PE 2007000212 A PE2007000212 A PE 2007000212A PE 20071311 A1 PE20071311 A1 PE 20071311A1
Authority
PE
Peru
Prior art keywords
azabicycle
alkyl
compounds
octane
antagonists
Prior art date
Application number
PE2007000212A
Other languages
English (en)
Inventor
Daniel D Long
Lan Jiang
Timothy J Church
John R Jacobsen
Daisuke Roland Saito
Dyke Priscilla M Van
Ioanna Stergiades
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071311(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of PE20071311A1 publication Critical patent/PE20071311A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REFERIDA A UN COMPUESTO 8-AZABICICLO[3.2.1]OCTANO DE FORMULA (I), DONDE R1 ES ORa, C(O)NRaRb, NHS(O)2Rc, CH2OH, ENTRE OTROS; A ES ALQUILENILO C1-C4; R2 ES CICLOALQUILO C3-C12 O ARILO C6-C10, OPCIONALMENTE SUSTITUIDOS CON ORa, HALO, ALQUILO C1-C3, ENTRE OTROS; G ES ALQUILENILO C1-C4; R3 ES H, C(O)R4, S(O)2Rc, ENTRE OTROS; R4 ES CICLOALQUILO C3-C6, ALQUILO C1-C6, ENTRE OTROS; Ra Y Rb SON H O ALQUILO C1-C4; Rc ES ALQUILO C1-C3. SON COMPUESTOS PREFERIDOS: 3-ENDO-(8-{2-[CICLOHEXILMETIL-(2-HIDROXIACETIL)-AMINO]ETIL}-8-AZABICICLO[3.2.1]OCT-3-IL)-BENZAMIDA, 3-ENDO-(8-{2.[BENCIL-(2-HIDROXIACETIL)-AMINO]ETIL}-8-AZABICICLO[3.2.1]OCT-3-IL)-BENZAMIDA, 3-ENDO-(8-{2-[CICLOHEXILMETIL-((S)-2,3-DIHIDROXI-PROPIONIL)AMINO]ETIL}-8-AZABICILO[3.2.1]OCT-3-IL)-BENZAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR OPIOIDE MU Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS GASTROINTESTINALES, DISFUNCION INTESTINAL INDUCIDA POR OIPIOIDES, ENTRE OTROS
PE2007000212A 2006-03-01 2007-02-28 Compuestos 8-azabiciclo[3.2.1]octano como antagonistas del receptor opioide mu PE20071311A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US84102806P 2006-08-30 2006-08-30

Publications (1)

Publication Number Publication Date
PE20071311A1 true PE20071311A1 (es) 2007-12-29

Family

ID=38436795

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000212A PE20071311A1 (es) 2006-03-01 2007-02-28 Compuestos 8-azabiciclo[3.2.1]octano como antagonistas del receptor opioide mu

Country Status (24)

Country Link
US (11) US7622508B2 (es)
EP (1) EP2001876B1 (es)
JP (2) JP5086280B2 (es)
KR (1) KR101376479B1 (es)
AR (1) AR059690A1 (es)
AT (1) ATE509928T1 (es)
AU (1) AU2007224213B2 (es)
BR (1) BRPI0708490B8 (es)
CA (1) CA2646409C (es)
CY (1) CY1111747T1 (es)
DK (1) DK2001876T3 (es)
HR (1) HRP20110590T1 (es)
IL (1) IL193690A (es)
MA (1) MA30284B1 (es)
MX (1) MX2008011165A (es)
MY (1) MY145633A (es)
NZ (1) NZ570764A (es)
PE (1) PE20071311A1 (es)
PL (1) PL2001876T3 (es)
PT (1) PT2001876E (es)
RU (1) RU2423362C2 (es)
SI (1) SI2001876T1 (es)
TW (1) TWI379832B (es)
WO (1) WO2007103187A2 (es)

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MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
EP2185553B1 (en) * 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2009029253A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
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WO2012055837A1 (de) 2010-10-27 2012-05-03 Bayer Cropscience Ag Heteroarylpiperidin und -piperazinderivate als fungizide
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HRP20200432T1 (hr) 2015-04-02 2020-06-12 Theravance Biopharma R&D Ip, Llc Oblik za kombinacijsko doziranje antagonista mu opioidnog receptora i opioidnog sredstva
MX2020008195A (es) 2018-02-05 2020-11-24 Alkermes Inc Compuestos para el tratamiento del dolor.
KR20230154789A (ko) * 2020-11-06 2023-11-09 액티노젠 메디컬 리미티드 헤테로고리 메탄온 화합물 및 그의 아자-비시클로 중간체의 제조 공정

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TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
EP2185553B1 (en) 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
DE602008005771D1 (de) 2007-08-27 2011-05-05 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten
WO2009029253A1 (en) 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Also Published As

Publication number Publication date
SI2001876T1 (sl) 2011-09-30
WO2007103187A2 (en) 2007-09-13
MA30284B1 (fr) 2009-03-02
US20160176863A1 (en) 2016-06-23
US20190308966A1 (en) 2019-10-10
MY145633A (en) 2012-03-15
ATE509928T1 (de) 2011-06-15
CA2646409C (en) 2015-11-10
US20170349578A1 (en) 2017-12-07
KR101376479B1 (ko) 2014-03-27
KR20080100282A (ko) 2008-11-14
PT2001876E (pt) 2011-08-18
DK2001876T3 (da) 2011-08-29
TW200800981A (en) 2008-01-01
HK1125935A1 (en) 2009-08-21
US7622508B2 (en) 2009-11-24
NZ570764A (en) 2011-08-26
RU2423362C2 (ru) 2011-07-10
BRPI0708490A2 (pt) 2011-05-31
US20100035921A1 (en) 2010-02-11
IL193690A0 (en) 2009-08-03
PL2001876T3 (pl) 2011-10-31
US20210024515A1 (en) 2021-01-28
JP2012211193A (ja) 2012-11-01
WO2007103187A3 (en) 2007-11-01
AR059690A1 (es) 2008-04-23
US20190119267A1 (en) 2019-04-25
US10081626B2 (en) 2018-09-25
US20130158060A1 (en) 2013-06-20
US8664242B2 (en) 2014-03-04
US9206172B2 (en) 2015-12-08
IL193690A (en) 2013-02-28
US8927573B2 (en) 2015-01-06
BRPI0708490B1 (pt) 2019-07-30
JP5086280B2 (ja) 2012-11-28
AU2007224213A1 (en) 2007-09-13
AU2007224213B2 (en) 2012-06-14
US11548887B2 (en) 2023-01-10
US9663509B2 (en) 2017-05-30
CY1111747T1 (el) 2015-10-07
EP2001876A2 (en) 2008-12-17
JP2009528371A (ja) 2009-08-06
EP2001876B1 (en) 2011-05-18
TWI379832B (en) 2012-12-21
US8263618B2 (en) 2012-09-11
BRPI0708490B8 (pt) 2021-05-25
US20070219278A1 (en) 2007-09-20
HRP20110590T1 (hr) 2011-09-30
US10745394B2 (en) 2020-08-18
US20230183232A1 (en) 2023-06-15
US20140288112A1 (en) 2014-09-25
CA2646409A1 (en) 2007-09-13
MX2008011165A (es) 2008-09-15
RU2008138875A (ru) 2010-04-10
US20150291579A1 (en) 2015-10-15
US10377751B2 (en) 2019-08-13

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