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DK2001876T3 - 8-Azabicyclo[3.2.1]octanforbindelser som mu-opioidreceptorantagonister - Google Patents

8-Azabicyclo[3.2.1]octanforbindelser som mu-opioidreceptorantagonister

Info

Publication number
DK2001876T3
DK2001876T3 DK07752111.0T DK07752111T DK2001876T3 DK 2001876 T3 DK2001876 T3 DK 2001876T3 DK 07752111 T DK07752111 T DK 07752111T DK 2001876 T3 DK2001876 T3 DK 2001876T3
Authority
DK
Denmark
Prior art keywords
azabicyclo
receptor antagonists
opioid receptor
octane compounds
octane
Prior art date
Application number
DK07752111.0T
Other languages
English (en)
Inventor
Daniel Long
Timothy J Church
John R Jacobsen
Lan Jiang
Daisuke Roland Saito
Ioanna Stergiades
Dyke Priscilla Van
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38436795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2001876(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Theravance Inc filed Critical Theravance Inc
Application granted granted Critical
Publication of DK2001876T3 publication Critical patent/DK2001876T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK07752111.0T 2006-03-01 2007-02-28 8-Azabicyclo[3.2.1]octanforbindelser som mu-opioidreceptorantagonister DK2001876T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77796206P 2006-03-01 2006-03-01
US84102806P 2006-08-30 2006-08-30
PCT/US2007/005388 WO2007103187A2 (en) 2006-03-01 2007-02-28 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Publications (1)

Publication Number Publication Date
DK2001876T3 true DK2001876T3 (da) 2011-08-29

Family

ID=38436795

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07752111.0T DK2001876T3 (da) 2006-03-01 2007-02-28 8-Azabicyclo[3.2.1]octanforbindelser som mu-opioidreceptorantagonister

Country Status (24)

Country Link
US (11) US7622508B2 (da)
EP (1) EP2001876B1 (da)
JP (2) JP5086280B2 (da)
KR (1) KR101376479B1 (da)
AR (1) AR059690A1 (da)
AT (1) ATE509928T1 (da)
AU (1) AU2007224213B2 (da)
BR (1) BRPI0708490B8 (da)
CA (1) CA2646409C (da)
CY (1) CY1111747T1 (da)
DK (1) DK2001876T3 (da)
HR (1) HRP20110590T1 (da)
IL (1) IL193690A (da)
MA (1) MA30284B1 (da)
MX (1) MX2008011165A (da)
MY (1) MY145633A (da)
NZ (1) NZ570764A (da)
PE (1) PE20071311A1 (da)
PL (1) PL2001876T3 (da)
PT (1) PT2001876E (da)
RU (1) RU2423362C2 (da)
SI (1) SI2001876T1 (da)
TW (1) TWI379832B (da)
WO (1) WO2007103187A2 (da)

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MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) * 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
EP2185553B1 (en) * 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
WO2009029253A1 (en) * 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
DE602008005771D1 (de) * 2007-08-27 2011-05-05 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten
JP5797655B2 (ja) * 2009-09-18 2015-10-21 アドラー・コーポレーション 消化管障害のためのオピオイド受容体アンタゴニストの使用
US20120122928A1 (en) 2010-08-11 2012-05-17 Bayer Cropscience Ag Heteroarylpiperidine and -Piperazine Derivatives as Fungicides
US8759527B2 (en) 2010-08-25 2014-06-24 Bayer Cropscience Ag Heteroarylpiperidine and -piperazine derivatives as fungicides
EP2423210A1 (de) 2010-08-25 2012-02-29 Bayer CropScience AG Heteroarylpiperidin- und -piperazinderivate als Fungizide
WO2012055837A1 (de) 2010-10-27 2012-05-03 Bayer Cropscience Ag Heteroarylpiperidin und -piperazinderivate als fungizide
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WO2012104273A1 (de) 2011-02-01 2012-08-09 Bayer Cropscience Ag Heteroarylpiperidin und -piperazinderivate als fungizide
WO2013037768A1 (de) 2011-09-15 2013-03-21 Bayer Intellectual Property Gmbh Piperidinpyrazole als fungizide
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CA2875384A1 (en) 2013-12-20 2015-06-20 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
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TWI409067B (zh) 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI415850B (zh) 2007-07-20 2013-11-21 Theravance Inc 製備ｍｕ類鴉片受體拮抗劑之中間物的方法
EP2185553B1 (en) 2007-08-27 2012-06-27 Theravance, Inc. Amidoalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
DE602008005771D1 (de) 2007-08-27 2011-05-05 Theravance Inc Disubstituierte alkyl-8-azabicycloä3.2.1üoktan-verbindungen als mu-opioid-rezeptorantagonisten
WO2009029253A1 (en) 2007-08-27 2009-03-05 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists

Also Published As

Publication number Publication date
SI2001876T1 (sl) 2011-09-30
WO2007103187A2 (en) 2007-09-13
MA30284B1 (fr) 2009-03-02
US20160176863A1 (en) 2016-06-23
US20190308966A1 (en) 2019-10-10
MY145633A (en) 2012-03-15
ATE509928T1 (de) 2011-06-15
CA2646409C (en) 2015-11-10
US20170349578A1 (en) 2017-12-07
KR101376479B1 (ko) 2014-03-27
KR20080100282A (ko) 2008-11-14
PT2001876E (pt) 2011-08-18
TW200800981A (en) 2008-01-01
HK1125935A1 (en) 2009-08-21
US7622508B2 (en) 2009-11-24
NZ570764A (en) 2011-08-26
RU2423362C2 (ru) 2011-07-10
PE20071311A1 (es) 2007-12-29
BRPI0708490A2 (pt) 2011-05-31
US20100035921A1 (en) 2010-02-11
IL193690A0 (en) 2009-08-03
PL2001876T3 (pl) 2011-10-31
US20210024515A1 (en) 2021-01-28
JP2012211193A (ja) 2012-11-01
WO2007103187A3 (en) 2007-11-01
AR059690A1 (es) 2008-04-23
US20190119267A1 (en) 2019-04-25
US10081626B2 (en) 2018-09-25
US20130158060A1 (en) 2013-06-20
US8664242B2 (en) 2014-03-04
US9206172B2 (en) 2015-12-08
IL193690A (en) 2013-02-28
US8927573B2 (en) 2015-01-06
BRPI0708490B1 (pt) 2019-07-30
JP5086280B2 (ja) 2012-11-28
AU2007224213A1 (en) 2007-09-13
AU2007224213B2 (en) 2012-06-14
US11548887B2 (en) 2023-01-10
US9663509B2 (en) 2017-05-30
CY1111747T1 (el) 2015-10-07
EP2001876A2 (en) 2008-12-17
JP2009528371A (ja) 2009-08-06
EP2001876B1 (en) 2011-05-18
TWI379832B (en) 2012-12-21
US8263618B2 (en) 2012-09-11
BRPI0708490B8 (pt) 2021-05-25
US20070219278A1 (en) 2007-09-20
HRP20110590T1 (hr) 2011-09-30
US10745394B2 (en) 2020-08-18
US20230183232A1 (en) 2023-06-15
US20140288112A1 (en) 2014-09-25
CA2646409A1 (en) 2007-09-13
MX2008011165A (es) 2008-09-15
RU2008138875A (ru) 2010-04-10
US20150291579A1 (en) 2015-10-15
US10377751B2 (en) 2019-08-13

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