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PE20071171A1 - Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropicos - Google Patents

Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropicos

Info

Publication number
PE20071171A1
PE20071171A1 PE2006001666A PE2006001666A PE20071171A1 PE 20071171 A1 PE20071171 A1 PE 20071171A1 PE 2006001666 A PE2006001666 A PE 2006001666A PE 2006001666 A PE2006001666 A PE 2006001666A PE 20071171 A1 PE20071171 A1 PE 20071171A1
Authority
PE
Peru
Prior art keywords
amine
alkyl
hydroxyl
halogen
phenyl
Prior art date
Application number
PE2006001666A
Other languages
English (en)
Inventor
Ralf Glatthar
David Orain
Carsten Spanka
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20071171A1 publication Critical patent/PE20071171A1/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES ALQUILO, BENCILO OPCIONALMENTE SUSTITUIDOS, R2 ES H, ALQUILO O BENCILO OPCIONALMENTE SUSTITUIDOS; O JUNTOS R1 Y R2 JUNTO AL ATOMO DE NITROGENO, HETEROCICLO OPCIONALMENTE SUSTITUIDOS; R3 ES HALOGENO, HIDROXILO, ALQUILO, ALCOXILO, AMINO, ENTRE OTROS; R4 ES HIDROXILO, HALOGENO, AMINO, ALQUIL-AMINO, ENTRE OTROS; Q ES CH, CR4, N; V ES CH, CR4, N; X ES CH, N; Y ES CH, CR3, N; Z ES CR6aR6b, NR5, O; R5 ES H, HIDROXILO; R6a Y R6b SON CADA UNO H, HALOGENO, HIDROXILO, AMINO, ALQUILO, ALCOXILO, HALOALQUILO. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE 6-(4-CLORO-FENIL-AMINO)-N,N-DIETIL-NICOTIN-AMIDA; CLORHIDRATO DE N,N-DIETIL-6-(4-METOXI-FENIL-AMINO)-NICOTIDIN-AMIDA; AZEPAN-1-IL-[6-(4-CLORO-FENIL-AMINO)-PIRIDIN-3-IL]-METANONA; ENTRE OTROS. REFERIDA TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES DE GLUTAMATO METABOTROPICOS HUMANOS (mGLURs) UTILES EN DISTINTOS TRASTORNOS RELACIONADOS CON EL TRACTO GASTROINTESTINAL Y URINARIO ASI COMO TRASTORNOS DEL SISTEMA NERVIOSO
PE2006001666A 2005-12-20 2006-12-20 Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropicos PE20071171A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05027934 2005-12-20
EP06120424 2006-09-11

Publications (1)

Publication Number Publication Date
PE20071171A1 true PE20071171A1 (es) 2008-01-22

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PE2006001666A PE20071171A1 (es) 2005-12-20 2006-12-20 Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropicos

Country Status (12)

Country Link
US (1) US20090005363A1 (es)
EP (1) EP1966144A1 (es)
JP (1) JP2009519986A (es)
KR (1) KR20080076962A (es)
AR (1) AR058554A1 (es)
AU (1) AU2006329007A1 (es)
BR (1) BRPI0620066A2 (es)
CA (1) CA2627630A1 (es)
PE (1) PE20071171A1 (es)
RU (1) RU2008129622A (es)
TW (1) TW200732323A (es)
WO (1) WO2007071358A1 (es)

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MX2009002684A (es) * 2006-09-11 2009-06-05 Novartis Ag Derivados de acido nicotinico como moduladores de receptores de glutamato metabotropico.
BRPI0814758A2 (pt) * 2007-08-03 2015-03-03 Hoffmann La Roche Piridinacarboxamida e derivados de benzamida como ligantes taar1
EP2211859B1 (en) * 2007-10-12 2016-01-06 Novartis AG Metabotropic glutamate receptor modulators for the treatment of parkinson's disease
WO2009047303A2 (en) * 2007-10-12 2009-04-16 Novartis Ag Metabotropic glutamate receptor modulators for the treatment of pervasive developmental disorder
KR20110027817A (ko) * 2008-06-30 2011-03-16 노파르티스 아게 Ｍｇｌｕｒ 조절제를 포함하는 파킨슨병 치료용 조합물
KR101754698B1 (ko) * 2008-12-19 2017-07-26 센트렉시온 테라퓨틱스 코포레이션 염증, 천식 및 ｃｏｐｄ 치료용 ｃｃｒ2 수용체 길항제로서의 사이클릭 피리미딘-4-카복스아미드
US8748623B2 (en) 2009-02-17 2014-06-10 Syntrix Biosystems, Inc. Pyridinecarboxamides as CXCR2 modulators
WO2011009890A2 (en) 2009-07-23 2011-01-27 Novartis Ag Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives
HRP20140621T1 (hr) * 2009-08-24 2014-11-21 Neuralstem, Inc. Sinteza neurostimulativnog piperazina
JP2013505297A (ja) * 2009-09-21 2013-02-14 ヴァンダービルト ユニバーシティー ｍＧｌｕＲ５の正のアロステリック調節因子としてのＯ−ベンジルニコチンアミド類似体
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
WO2011048150A1 (en) 2009-10-20 2011-04-28 Novartis Ag Use of 1h-quinazoline-2,4-diones
HRP20141143T1 (hr) 2009-12-17 2015-01-02 Boehringer Ingelheim International Gmbh Novi antagonisti receptora ccr2 i njihove uporabe
EP2575461A4 (en) * 2010-05-24 2013-12-18 Univ Vanderbilt SUBSTITUTED 6-METHYLNICOTINAMIDES USEFUL AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR5
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