[go: up one dir, main page]

PE20070167A1 - COMPUESTOS 5H-BENZO[4,5]CICLOHEPTA[1,2-b]PIRIDINA COMO INHIBIDORES DE TIROSINA QUINASA - Google Patents

COMPUESTOS 5H-BENZO[4,5]CICLOHEPTA[1,2-b]PIRIDINA COMO INHIBIDORES DE TIROSINA QUINASA

Info

Publication number
PE20070167A1
PE20070167A1 PE2006000702A PE2006000702A PE20070167A1 PE 20070167 A1 PE20070167 A1 PE 20070167A1 PE 2006000702 A PE2006000702 A PE 2006000702A PE 2006000702 A PE2006000702 A PE 2006000702A PE 20070167 A1 PE20070167 A1 PE 20070167A1
Authority
PE
Peru
Prior art keywords
cyclohepta
benzo
compounds
alkyl
pyridine
Prior art date
Application number
PE2006000702A
Other languages
English (en)
Inventor
Christopher J Dinsmore
James P Jewell
Michelle R Machacek
Jonathan R Young
Ryan D Otte
Jason D Katz
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of PE20070167A1 publication Critical patent/PE20070167A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS 5H-BENZO[4,5]CICLOHEPTA[1,2-b]PIRIDINA, DE FORMULA (I) DONDE R1 ES ARILO, HETEROARILO AMBOS OPCIONALMENTE SUSTITUIDOS CON 1 A 5 SUSTITUYENTES R8; O NR10R11; DONDE R10 Y R11 SON INDEPENDIENTEMENTE H, (C=O)ObALQUILO(C1-C10), (C=O)ObCICLOALQUILO(C3-C8), ENTRE OTROS; R5 ES H, ALQUILO(C1-C6), ALQUENILO(C2-C6), -O-ALQUILO(C1-C6), -O-C(=O)ALQUILO(C1-C6), ENTRE OTROS; b ES 0 O 1. SON COMPUESTOS PREFERIDOS: 3-FENIL-7-VINIL-5H-BENZOL[4,5]CICLOHEPTA[1,2-b]PIRIDIN-5-ONA, 7-ETIL-3-FENIL-5H-BENZO[4,5]CICLOHEPTA[1,2-b]PIRIDIN-5-ONA, 7-[(2,4-DIMETOXIBENCIL)AMINO]-3-FENIL-5H-BENZO[4,5]CICLOHEPTA[1,2-b]PIRIDIN-5-ONA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. LOS COMPUESTOS SON INHIBIDORES DE LA TIROSINA QUINASA DEL RECEPTOR MET Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS CELULARES TAL COMO CANCER, HIPERPLASIAS, TRASTORNOS INMUNES E INFLAMACION
PE2006000702A 2005-06-23 2006-06-21 COMPUESTOS 5H-BENZO[4,5]CICLOHEPTA[1,2-b]PIRIDINA COMO INHIBIDORES DE TIROSINA QUINASA PE20070167A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69322905P 2005-06-23 2005-06-23
US72906105P 2005-10-21 2005-10-21
US78947306P 2006-04-05 2006-04-05

Publications (1)

Publication Number Publication Date
PE20070167A1 true PE20070167A1 (es) 2007-04-16

Family

ID=37595817

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000702A PE20070167A1 (es) 2005-06-23 2006-06-21 COMPUESTOS 5H-BENZO[4,5]CICLOHEPTA[1,2-b]PIRIDINA COMO INHIBIDORES DE TIROSINA QUINASA

Country Status (21)

Country Link
EP (1) EP1896422B1 (es)
KR (1) KR20080018907A (es)
AR (1) AR057377A1 (es)
AT (1) ATE520664T1 (es)
BR (1) BRPI0612518A2 (es)
CR (1) CR9579A (es)
CY (1) CY1112038T1 (es)
DO (1) DOP2006000143A (es)
EC (1) ECSP078017A (es)
IL (1) IL187895A0 (es)
MA (1) MA29643B1 (es)
MX (1) MX2007016533A (es)
NI (1) NI200700318A (es)
NO (1) NO20080417L (es)
NZ (1) NZ563711A (es)
PE (1) PE20070167A1 (es)
PL (1) PL1896422T3 (es)
PT (1) PT1896422E (es)
SI (1) SI1896422T1 (es)
TW (1) TW200738638A (es)
WO (1) WO2007002258A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
US7893081B2 (en) * 2007-12-20 2011-02-22 Merck & Co., Inc. Tyrosine kinase inhibitors
JP5775085B2 (ja) 2009-09-30 2015-09-09 メルク シャープ エンド ドーム リミテッド ｃ−ＭＥＴキナーゼ阻害剤の製剤
EP2482821A4 (en) 2009-09-30 2013-03-06 Merck Sharp & Dohme CRYSTALLINE HYDROCHLORIDE SALTS FROM C-MET KINASE INHIBITORS
US20130315895A1 (en) 2010-07-01 2013-11-28 Takeda Pharmaceutical Company Limited COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET
ES2764299T3 (es) 2014-12-09 2020-06-02 Inst Nat Sante Rech Med Anticuerpos monoclonales humanos contra AXL
WO2016135041A1 (en) 2015-02-26 2016-09-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Fusion proteins and antibodies comprising thereof for promoting apoptosis
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04002682A (es) * 2001-09-19 2004-06-18 Pharmacia Corp Compuestos pirazolilo sustituidos para el tratamiento de la inflamacion.
WO2003084931A1 (en) * 2002-04-02 2003-10-16 Merck & Co., Inc. 5h-benzo[4,5]cyclohepta[1,2-b]pyridine nmda/nr2b antagonists

Also Published As

Publication number Publication date
NO20080417L (no) 2008-03-18
KR20080018907A (ko) 2008-02-28
CY1112038T1 (el) 2015-11-04
TW200738638A (en) 2007-10-16
DOP2006000143A (es) 2007-02-28
WO2007002258A3 (en) 2007-06-07
PL1896422T3 (pl) 2012-01-31
MA29643B1 (fr) 2008-07-01
NI200700318A (es) 2008-05-23
IL187895A0 (en) 2008-03-20
NZ563711A (en) 2010-12-24
EP1896422A2 (en) 2008-03-12
BRPI0612518A2 (pt) 2010-11-23
ATE520664T1 (de) 2011-09-15
CR9579A (es) 2008-03-06
EP1896422B1 (en) 2011-08-17
AR057377A1 (es) 2007-11-28
MX2007016533A (es) 2008-03-06
WO2007002258A2 (en) 2007-01-04
PT1896422E (pt) 2011-11-08
ECSP078017A (es) 2008-01-23
SI1896422T1 (sl) 2011-11-30

Similar Documents

Publication Publication Date Title
PE20220931A1 (es) Inhibidores de shp2 fosfatasa de tipo pirazolo[3,4-b]pirazina
PE20191613A1 (es) Compuestos de pirazolo[1,5-a]piridina sustituidos como inhibidores de la quinasa ret
PE20160875A1 (es) Compuestos de biaril-amida como inhibidores de cinasa
MX2022006475A (es) Compuestos triciclicos sustituidos.
PE20212303A1 (es) Inhibidores aza-heterobiciclicos de mat2a y metodos de uso en el tratamiento de cancer
NZ766835A (en) Pharmaceutical compounds
EA200601350A1 (ru) Азотсодержащие гетероциклические производные и их фармацевтические применения
EA202090659A1 (ru) СОСТАВЫ, СОДЕРЖАЩИЕ 6-(2-ГИДРОКСИ-2-МЕТИЛПРОПОКСИ)-4-(6-(6-((6-МЕТОКСИПИРИДИН-3-ИЛ)МЕТИЛ)-3,6-ДИАЗАБИЦИКЛО[3.1.1]ГЕПТАН-3-ИЛ)ПИРИДИН-3-ИЛ)ПИРАЗОЛО[1,5-a]ПИРИДИН-3-КАРБОНИТРИЛ
MY206521A (en) Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof
PE20181491A1 (es) Nuevos derivados biciclicos, un proceso para su preparacion y composiciones farmaceuticas que los contienen
PE20170247A1 (es) Derivados de pirrolidina-2,5-diona, composiciones farmaceuticas y metodos para usar como inhibidores ido1
CL2012001699A1 (es) Compuestos derivados de n-(1h-indazol-4-il)imidazo[1,2-a]piridin-3-carboxamida sustituidos, inhibidores de cfms; proceso de preparacion; composicion farmaceutica que los comprende; uso del compuesto para el tratamiento de enfermedades relacionadas con huesos, cancer, trastornos autoinmunes, enfermedades inflamatorias, entre otras.
ECSP056194A (es) Derivados de pirazolo-quinazolina, procedimiento para su preparacion y su uso como inhibidores de quinasa
PE20120534A1 (es) PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt
PE20170003A1 (es) Compuestos heterociclicos y usos de los mismos
PA8593001A1 (es) Derivados de pirimidina para el tratamiento del crecimiento celular anormal
EA200870373A1 (ru) Пиридил- и пиримидинилзамещённые производные пиррола, тиофена и фурана в качестве ингибиторов киназ
EA200700099A1 (ru) Производные пиридина
PE20010211A1 (es) Compuestos de tiazol y composiciones farmaceuticas para inhibir las quinasas de proteina
EA201000615A1 (ru) Производные имидазо[1,2-а]пиридина, применимые в качестве ингибиторов апк (активиноподобной киназы)
CO5700778A2 (es) Administracion combinada de una indolinona con un agente quimioterapeutico para trastornos de proliferacion celular
DE602005016261D1 (de) Substituierte arylaminderivate und verwendungsverfahren
EA201101566A1 (ru) Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ
DE602008003322D1 (de) Pyrrolo (3, 2, 1-ij) chinolin-4-on-derivate zur behandlung von tuberkulose
CL2007001711A1 (es) Compuestos derivados de pirazolopiridina sustituida;composicion farmaceutica que los comprende;metodo de preparacion de los compuestos ,compuestos intermediarios;y su uso en el tratamiento de enfermedades,tales como tumores,artritis reumatoide,enfermedades del crecimiento vascular desregulado, entre otras.

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed