PE20070724A1 - Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas - Google Patents
Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasasInfo
- Publication number
- PE20070724A1 PE20070724A1 PE2006001257A PE2006001257A PE20070724A1 PE 20070724 A1 PE20070724 A1 PE 20070724A1 PE 2006001257 A PE2006001257 A PE 2006001257A PE 2006001257 A PE2006001257 A PE 2006001257A PE 20070724 A1 PE20070724 A1 PE 20070724A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- lipase
- halogen
- phospholipase inhibitors
- carbamoylbenzotriazole
- Prior art date
Links
- VKMHAJDSSBSCEM-UHFFFAOYSA-N 2h-benzotriazole-4-carboxamide Chemical class NC(=O)C1=CC=CC2=C1N=NN2 VKMHAJDSSBSCEM-UHFFFAOYSA-N 0.000 title 1
- 102000004882 Lipase Human genes 0.000 title 1
- 108090001060 Lipase Proteins 0.000 title 1
- 239000004367 Lipase Substances 0.000 title 1
- 235000019421 lipase Nutrition 0.000 title 1
- 239000003428 phospholipase inhibitor Substances 0.000 title 1
- -1 BENZOTRIAZOLE DERIVATIVE COMPOUND Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000032928 Dyslipidaemia Diseases 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 229940127470 Lipase Inhibitors Drugs 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000004129 fatty acid metabolism Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
REFERIDA A UN COMPUESTO DERIVADO DE BENZOTRIAZOL DE FORMULA (I), DONDE W ES C=O, SO, SO2; R1 ES ALQUILO C5-C16, X-ARILO, X-CICLOALQUILO C5-C12, ENTRE OTROS; X ES ALQUILENO C1-C3 QUE PUEDE ESTAR SUSTITUIDO UNA O VARIAS VECES CON HALOGENO, ALQUILO C1-C3, HIDROXI O TRIFLUOROMETILO; R2, R3, R4 Y R5 SON H, HALOGENO, ALQUILO C1-C6, CIANO, NITRO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE LA LIPASA Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS DEL METABOLISMO DE LOS ACIDOS GRASOS, DIABETES MELLITUS, ESPECIALMENTE LA TIPO 2, DISLIPIDEMIAS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005049953A DE102005049953A1 (de) | 2005-10-19 | 2005-10-19 | Carbamoylbenzotriazol-derivate als Inhibitoren von Lipasen und Phospholipasen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070724A1 true PE20070724A1 (es) | 2007-08-07 |
Family
ID=37667178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001257A PE20070724A1 (es) | 2005-10-19 | 2006-10-17 | Derivados de carbamoilbenzotriazol como inhibidores de lipasas y fosfolipasas |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US7897625B2 (es) |
| EP (1) | EP1940807B1 (es) |
| JP (1) | JP2009512650A (es) |
| KR (1) | KR20080063474A (es) |
| CN (1) | CN101291918A (es) |
| AR (1) | AR057554A1 (es) |
| AU (1) | AU2006303552A1 (es) |
| BR (1) | BRPI0617613A2 (es) |
| CA (1) | CA2625722A1 (es) |
| CR (1) | CR9850A (es) |
| DE (1) | DE102005049953A1 (es) |
| DO (1) | DOP2006000226A (es) |
| EC (1) | ECSP088377A (es) |
| GT (1) | GT200600463A (es) |
| HN (1) | HN2006035238A (es) |
| IL (1) | IL190714A0 (es) |
| MA (1) | MA29858B1 (es) |
| NO (1) | NO20081942L (es) |
| NZ (1) | NZ567573A (es) |
| PE (1) | PE20070724A1 (es) |
| RU (1) | RU2430096C2 (es) |
| TN (1) | TNSN08177A1 (es) |
| TW (1) | TW200730513A (es) |
| UY (1) | UY29872A1 (es) |
| WO (1) | WO2007045393A1 (es) |
| ZA (1) | ZA200802370B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008042422A2 (en) * | 2006-10-04 | 2008-04-10 | Schering Corporation | Bicyclic and tricyclic derivatives as thrombin receptor antagonists |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US8470841B2 (en) | 2008-07-09 | 2013-06-25 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| WO2010044441A1 (ja) | 2008-10-17 | 2010-04-22 | 塩野義製薬株式会社 | 血管内皮リパーゼ阻害活性を有する酢酸アミド誘導体 |
| CN105399731A (zh) * | 2008-12-24 | 2016-03-16 | 比亚尔-珀特拉和Ca股份公司 | 药物化合物 |
| US8975286B2 (en) * | 2009-08-20 | 2015-03-10 | Merck Sharp & Dohme Corp. | Ether benzotriazole derivatives |
| KR20120123325A (ko) | 2009-12-15 | 2012-11-08 | 시오노기세야쿠 가부시키가이샤 | 혈관 내피 리파아제 저해 활성을 갖는 옥사디아졸 유도체 |
| US8450350B2 (en) * | 2010-05-05 | 2013-05-28 | Infinity Pharmaceuticals, Inc. | Triazoles as inhibitors of fatty acid synthase |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8476302B2 (en) * | 2010-09-27 | 2013-07-02 | Janssen Pharmaceutica N.V. | α-ketoamide derivatives useful endothelial lipase inhibitors |
| US9630932B2 (en) | 2013-02-25 | 2017-04-25 | Um Pharmauji Sdn. Bhd. | Trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
| RU2563254C2 (ru) * | 2013-07-08 | 2015-09-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина |
| RU2553987C1 (ru) * | 2013-12-26 | 2015-06-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургский государственный университет" (СПбГУ) | N-адамантилбензотриазолы, проявляющие активность против вируса гриппа а, и способ их получения |
| CN104292172B (zh) * | 2014-09-12 | 2016-08-17 | 浙江理工大学 | 一种苯并三氮唑类衍生物及其制备方法 |
| IL270066B2 (en) * | 2017-04-24 | 2023-10-01 | Aurigene Oncology Ltd | Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors |
| US20180369206A1 (en) | 2017-04-24 | 2018-12-27 | Aurigene Discovery Technologies Limited | Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors |
| KR102861339B1 (ko) | 2018-02-20 | 2025-09-19 | 르 라보레또레 쎄르비에르 | 삼치환 벤조트리아졸 유도체의 사용 방법 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1035188A (en) * | 1974-08-15 | 1978-07-25 | Eastman Kodak Company | Blocked development restrainers |
| US4273860A (en) * | 1977-12-28 | 1981-06-16 | Eastman Kodak Company | Inhibition of image formation utilizing cobalt(III) complexes |
| CA1126999A (en) | 1978-10-20 | 1982-07-06 | Michael J. Simons | Use of azole compounds with a n,n disubstituted carbamoyl group on a ring nitrogen as development restrainer precursors in photographic elements |
| JPS6239573A (ja) * | 1985-08-13 | 1987-02-20 | Sumitomo Chem Co Ltd | シクロアルケニルアミド誘導体、その製造法およびそれを有効成分とする土壌病害防除剤 |
| US6440648B1 (en) * | 2000-06-13 | 2002-08-27 | Eastman Kodak Company | Color photographic element having improved contrast and compatibility with both dry and conventional processing |
| US6372421B1 (en) * | 2000-06-13 | 2002-04-16 | Eastman Kodak Company | Photothermographic imaging element having improved contrast and methods of image formation |
| ES2299567T3 (es) | 2001-05-05 | 2008-06-01 | Smithkline Beecham Plc | N-aroilaminas ciclicas. |
| KR20040068240A (ko) | 2001-12-14 | 2004-07-30 | 노보 노르디스크 에이/에스 | 호르몬 민감성 리파아제의 활성을 감소시키기 위한 화합물및 그들의 사용 |
| DE10247680B4 (de) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | Neue bicyclische Inhibitoren der Hormon Sensitiven Lipase |
| ES2330636T3 (es) * | 2003-03-31 | 2009-12-14 | Eli Lilly And Company | Derivados amida del acido 3-oxo-1,3-dihidro-indazol-2-carboxilico como inhibidores de la fosfolipasa. |
-
2005
- 2005-10-19 DE DE102005049953A patent/DE102005049953A1/de not_active Ceased
-
2006
- 2006-10-12 AU AU2006303552A patent/AU2006303552A1/en not_active Abandoned
- 2006-10-12 CN CNA2006800384397A patent/CN101291918A/zh active Pending
- 2006-10-12 KR KR1020087009298A patent/KR20080063474A/ko not_active Withdrawn
- 2006-10-12 CA CA002625722A patent/CA2625722A1/en not_active Abandoned
- 2006-10-12 NZ NZ567573A patent/NZ567573A/en not_active IP Right Cessation
- 2006-10-12 EP EP06806216.5A patent/EP1940807B1/de active Active
- 2006-10-12 BR BRPI0617613-5A patent/BRPI0617613A2/pt not_active IP Right Cessation
- 2006-10-12 JP JP2008535942A patent/JP2009512650A/ja not_active Abandoned
- 2006-10-12 WO PCT/EP2006/009857 patent/WO2007045393A1/de not_active Ceased
- 2006-10-12 RU RU2008119460/04A patent/RU2430096C2/ru not_active IP Right Cessation
- 2006-10-17 AR ARP060104521A patent/AR057554A1/es unknown
- 2006-10-17 DO DO2006000226A patent/DOP2006000226A/es unknown
- 2006-10-17 TW TW095138145A patent/TW200730513A/zh unknown
- 2006-10-17 PE PE2006001257A patent/PE20070724A1/es not_active Application Discontinuation
- 2006-10-17 GT GT200600463A patent/GT200600463A/es unknown
- 2006-10-18 HN HN2006035238A patent/HN2006035238A/es unknown
- 2006-10-18 UY UY29872A patent/UY29872A1/es not_active Application Discontinuation
-
2008
- 2008-03-13 ZA ZA200802370A patent/ZA200802370B/xx unknown
- 2008-03-28 CR CR9850A patent/CR9850A/es not_active Application Discontinuation
- 2008-04-08 MA MA30825A patent/MA29858B1/fr unknown
- 2008-04-08 IL IL190714A patent/IL190714A0/en unknown
- 2008-04-09 US US12/099,924 patent/US7897625B2/en not_active Expired - Fee Related
- 2008-04-17 EC EC2008008377A patent/ECSP088377A/es unknown
- 2008-04-18 TN TNP2008000177A patent/TNSN08177A1/en unknown
- 2008-04-23 NO NO20081942A patent/NO20081942L/no not_active Application Discontinuation
-
2011
- 2011-01-20 US US13/009,951 patent/US20110118321A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HN2006035238A (es) | 2010-05-24 |
| RU2430096C2 (ru) | 2011-09-27 |
| GT200600463A (es) | 2007-05-21 |
| ECSP088377A (es) | 2008-05-30 |
| BRPI0617613A2 (pt) | 2011-08-02 |
| WO2007045393A1 (de) | 2007-04-26 |
| CR9850A (es) | 2008-06-18 |
| NZ567573A (en) | 2010-06-25 |
| KR20080063474A (ko) | 2008-07-04 |
| US7897625B2 (en) | 2011-03-01 |
| EP1940807B1 (de) | 2015-06-17 |
| CA2625722A1 (en) | 2007-04-26 |
| DOP2006000226A (es) | 2007-05-15 |
| AR057554A1 (es) | 2007-12-05 |
| US20080287503A1 (en) | 2008-11-20 |
| RU2008119460A (ru) | 2009-11-27 |
| TNSN08177A1 (en) | 2009-10-30 |
| CN101291918A (zh) | 2008-10-22 |
| NO20081942L (no) | 2008-04-23 |
| IL190714A0 (en) | 2008-11-03 |
| UY29872A1 (es) | 2007-05-31 |
| MA29858B1 (fr) | 2008-10-03 |
| AU2006303552A1 (en) | 2007-04-26 |
| TW200730513A (en) | 2007-08-16 |
| JP2009512650A (ja) | 2009-03-26 |
| DE102005049953A1 (de) | 2007-04-26 |
| EP1940807A1 (de) | 2008-07-09 |
| ZA200802370B (en) | 2008-12-31 |
| US20110118321A1 (en) | 2011-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |