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PE20070713A1 - 4-AMINO-5-CHLORO-N - {[1- (TETRAHYDRO-2H-PYRAN-4-ILMETYL) -4-PIPERIDINYL] METHYL} -1-BENZOFURAN-7-CARBOXAMIDE IN THE TREATMENT OF ALZHEIMER - Google Patents

4-AMINO-5-CHLORO-N - {[1- (TETRAHYDRO-2H-PYRAN-4-ILMETYL) -4-PIPERIDINYL] METHYL} -1-BENZOFURAN-7-CARBOXAMIDE IN THE TREATMENT OF ALZHEIMER

Info

Publication number
PE20070713A1
PE20070713A1 PE2006001310A PE2006001310A PE20070713A1 PE 20070713 A1 PE20070713 A1 PE 20070713A1 PE 2006001310 A PE2006001310 A PE 2006001310A PE 2006001310 A PE2006001310 A PE 2006001310A PE 20070713 A1 PE20070713 A1 PE 20070713A1
Authority
PE
Peru
Prior art keywords
benzofuran
pyran
carboxamide
tetrahydro
chloro
Prior art date
Application number
PE2006001310A
Other languages
Spanish (es)
Inventor
Mohammed Mahmood Ahmed
Neil Derek Miller
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0522071A external-priority patent/GB0522071D0/en
Priority claimed from GB0619950A external-priority patent/GB0619950D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20070713A1 publication Critical patent/PE20070713A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE 4-AMINO-5-CLORO-N-{[1-(TETRAHIDRO-2H-PIRAN-4-ILMETIL)-4-PIPERIDINIL]METIL}-1-BENZOFURAN-7-CARBOXAMIDA Y SUS SALES DE TOSILATO, TOSILATO MONOHIDRATO, TOSILATO ANHIDRO. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION QUE COMPRENDE: A) REACCIONAR 4-AMINO-5-CLORO-N-(4-PIPERIDINILMETIL)-1-BENZOFURAN-7-CARBOXAMIDA O UNA SAL O DERIVADO PROTEGIDO DE LA MISMA CON TETRAHIDRO-2H-PIRAN-4-CARBALDEHIDO; B) DESPROTEGER EL COMPUESTO; C) FORMAR LA SAL FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECEPTOR 5-HT4, UTILES EN EL TRATAMIENTO DE ALZHEIMERREFERS TO A COMPOUND OF 4-AMINO-5-CHLORO-N - {[1- (TETRAHYDRO-2H-PYRAN-4-ILMETYL) -4-PIPERIDINYL] METHYL} -1-BENZOFURAN-7-CARBOXAMIDE AND ITS SALTS OF TOSILATE, TOSYLATE MONOHYDRATE, TOSYLATE ANHYDRO. ALSO REFERRED TO A PREPARATION PROCEDURE THAT INCLUDES: A) REACTING 4-AMINO-5-CHLORO-N- (4-PIPERIDINYLMETHYL) -1-BENZOFURAN-7-CARBOXAMIDE OR A SALT OR PROTECTED DERIVATIVE OF THE SAME WITH TETRAHYDRO-2H- PYRAN-4-CARBALDEHYDE; B) UNPROTECT THE COMPOUND; C) FORM THE PHARMACEUTICAL SALT. SUCH COMPOUNDS ARE AGONISTS OF THE 5-HT4 RECEPTOR, USEFUL IN THE TREATMENT OF ALZHEIMER

PE2006001310A 2005-10-28 2006-10-26 4-AMINO-5-CHLORO-N - {[1- (TETRAHYDRO-2H-PYRAN-4-ILMETYL) -4-PIPERIDINYL] METHYL} -1-BENZOFURAN-7-CARBOXAMIDE IN THE TREATMENT OF ALZHEIMER PE20070713A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0522071A GB0522071D0 (en) 2005-10-28 2005-10-28 Novel compound
GB0619950A GB0619950D0 (en) 2006-10-09 2006-10-09 Novel compounds

Publications (1)

Publication Number Publication Date
PE20070713A1 true PE20070713A1 (en) 2007-09-27

Family

ID=37591731

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001310A PE20070713A1 (en) 2005-10-28 2006-10-26 4-AMINO-5-CHLORO-N - {[1- (TETRAHYDRO-2H-PYRAN-4-ILMETYL) -4-PIPERIDINYL] METHYL} -1-BENZOFURAN-7-CARBOXAMIDE IN THE TREATMENT OF ALZHEIMER

Country Status (4)

Country Link
AR (1) AR056729A1 (en)
PE (1) PE20070713A1 (en)
TW (1) TW200732327A (en)
WO (1) WO2007048643A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011092293A2 (en) 2010-02-01 2011-08-04 Novartis Ag Cyclohexyl amide derivatives as crf receptor antagonists
CN102762572A (en) 2010-02-01 2012-10-31 诺瓦提斯公司 Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
CN102753527B (en) 2010-02-02 2014-12-24 诺华股份有限公司 Cyclohexyl amide derivatives as crf receptor antagonists
PL3265459T3 (en) * 2015-02-13 2019-09-30 Suven Life Sciences Limited Amide compounds as 5-ht4 receptor agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0820586A (en) * 1994-07-05 1996-01-23 Sanwa Kagaku Kenkyusho Co Ltd 1-azbicyclo(octane derivative, its salt, production and use
WO2005092882A1 (en) * 2004-03-01 2005-10-06 Pfizer Japan, Inc. 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders

Also Published As

Publication number Publication date
TW200732327A (en) 2007-09-01
WO2007048643A1 (en) 2007-05-03
AR056729A1 (en) 2007-10-17

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