AR056729A1 - COMPOSITE OF BENZOFURAN CARBOXAMIDE, PHARMACEUTICAL COMPOSITION UNDERSTANDING ITS USE TO PREPARE A MEDICINAL PRODUCT AND PROCESSES FOR PREPARATION - Google Patents
COMPOSITE OF BENZOFURAN CARBOXAMIDE, PHARMACEUTICAL COMPOSITION UNDERSTANDING ITS USE TO PREPARE A MEDICINAL PRODUCT AND PROCESSES FOR PREPARATIONInfo
- Publication number
- AR056729A1 AR056729A1 ARP060104683A ARP060104683A AR056729A1 AR 056729 A1 AR056729 A1 AR 056729A1 AR P060104683 A ARP060104683 A AR P060104683A AR P060104683 A ARP060104683 A AR P060104683A AR 056729 A1 AR056729 A1 AR 056729A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- processes
- pharmaceutical composition
- benzofuran
- prepare
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- QHKJIJXBJCOABP-UHFFFAOYSA-N 1-benzofuran-2-carboxamide Chemical compound C1=CC=C2OC(C(=O)N)=CC2=C1 QHKJIJXBJCOABP-UHFFFAOYSA-N 0.000 title 1
- 239000002131 composite material Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- ZXVBXMMWTGCOCZ-UHFFFAOYSA-N 4-amino-5-chloro-1-benzofuran-7-carboxylic acid Chemical compound NC1=C(Cl)C=C(C(O)=O)C2=C1C=CO2 ZXVBXMMWTGCOCZ-UHFFFAOYSA-N 0.000 abstract 1
- SDTGSBHXCGAHQY-UHFFFAOYSA-N 4-amino-5-chloro-n-(piperidin-4-ylmethyl)-1-benzofuran-7-carboxamide Chemical compound C1=2OC=CC=2C(N)=C(Cl)C=C1C(=O)NCC1CCNCC1 SDTGSBHXCGAHQY-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 230000008484 agonism Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000004682 monohydrates Chemical class 0.000 abstract 1
- CXLGNJCMPWUZKM-UHFFFAOYSA-N oxane-4-carbaldehyde Chemical compound O=CC1CCOCC1 CXLGNJCMPWUZKM-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 tetrahydro-2H-pyranylmethyl Chemical group 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto 4-amino-5-cloro-N-{[1-(tetrahidro-2H-piran-4-ilmetil]metil}-1-benzofuran-7-carboxamida (A), o una de sus sales farmacéuticamente aceptables, por ejemplo hidrocloruro, tosilato como monohidrato o anhidrato. Composicion farmacéutica que lo comprende. Su uso para la preparacion de un medicamento util para el tratamiento de enfermedades tratables mediante agonismo de 5-HT4. Procesos para su preparacion a partir de 4-amino-5-cloro-N-(4-piperidinilmetil)-1-benzofuran-7-carboxamida y tetrahidro-2H-piran-4-carbaldehído o de ácido 4-amino-5-cloro-1-benzofuran-7-carboxílico y {[1-(tetrahídro-2H-piranilmetil)-4-piperidinil]metil}amina.A 4-amino-5-chloro-N - {[1- (tetrahydro-2H-pyran-4-ylmethyl] methyl} -1-benzofuran-7-carboxamide (A) compound, or a pharmaceutically acceptable salt thereof, by example hydrochloride, tosylate as monohydrate or anhydrate Pharmaceutical composition comprising it.Its use for the preparation of a medicament useful for the treatment of diseases treatable by 5-HT4 agonism.Processes for its preparation from 4-amino-5- Chloro-N- (4-piperidinylmethyl) -1-benzofuran-7-carboxamide and tetrahydro-2H-pyran-4-carbaldehyde or 4-amino-5-chloro-1-benzofuran-7-carboxylic acid and {[1- (tetrahydro-2H-pyranylmethyl) -4-piperidinyl] methyl} amine.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0522071A GB0522071D0 (en) | 2005-10-28 | 2005-10-28 | Novel compound |
| GB0619950A GB0619950D0 (en) | 2006-10-09 | 2006-10-09 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056729A1 true AR056729A1 (en) | 2007-10-17 |
Family
ID=37591731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060104683A AR056729A1 (en) | 2005-10-28 | 2006-10-26 | COMPOSITE OF BENZOFURAN CARBOXAMIDE, PHARMACEUTICAL COMPOSITION UNDERSTANDING ITS USE TO PREPARE A MEDICINAL PRODUCT AND PROCESSES FOR PREPARATION |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR056729A1 (en) |
| PE (1) | PE20070713A1 (en) |
| TW (1) | TW200732327A (en) |
| WO (1) | WO2007048643A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102762572A (en) | 2010-02-01 | 2012-10-31 | 诺瓦提斯公司 | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| US8835444B2 (en) | 2010-02-02 | 2014-09-16 | Novartis Ag | Cyclohexyl amide derivatives as CRF receptor antagonists |
| CN107406434B (en) | 2015-02-13 | 2020-09-11 | 苏文生命科学有限公司 | Amide compounds as 5-HT4 receptor agonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0820586A (en) * | 1994-07-05 | 1996-01-23 | Sanwa Kagaku Kenkyusho Co Ltd | 1-azbicyclo(octane derivative, its salt, production and use |
| WO2005092882A1 (en) * | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
-
2006
- 2006-10-26 PE PE2006001310A patent/PE20070713A1/en not_active Application Discontinuation
- 2006-10-26 WO PCT/EP2006/010438 patent/WO2007048643A1/en not_active Ceased
- 2006-10-26 AR ARP060104683A patent/AR056729A1/en unknown
- 2006-10-26 TW TW095139451A patent/TW200732327A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007048643A1 (en) | 2007-05-03 |
| TW200732327A (en) | 2007-09-01 |
| PE20070713A1 (en) | 2007-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |