PE20070530A1 - COMPOUNDS DERIVED FROM THIAZOLS SUBSTITUTED AS OPENING AGENTS OF HIGH CONDUCTANCE ACTIVATED POTASSIUM CHANNELS - Google Patents
COMPOUNDS DERIVED FROM THIAZOLS SUBSTITUTED AS OPENING AGENTS OF HIGH CONDUCTANCE ACTIVATED POTASSIUM CHANNELSInfo
- Publication number
- PE20070530A1 PE20070530A1 PE2006001294A PE2006001294A PE20070530A1 PE 20070530 A1 PE20070530 A1 PE 20070530A1 PE 2006001294 A PE2006001294 A PE 2006001294A PE 2006001294 A PE2006001294 A PE 2006001294A PE 20070530 A1 PE20070530 A1 PE 20070530A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- potassium channels
- thiazols
- substituted
- high conductance
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 102000004257 Potassium Channel Human genes 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 108020001213 potassium channel Proteins 0.000 title abstract 2
- 150000003109 potassium Chemical class 0.000 title 1
- -1 ISOPROPYL Chemical group 0.000 abstract 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 4
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 108091006146 Channels Proteins 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 206010020853 Hypertonic bladder Diseases 0.000 abstract 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical group [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 208000020629 overactive bladder Diseases 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA (I) DONDE R1 ES ETILO, PROPILO O ISOPROPILO; R2 ES H, CLORO, FLUOR O METILO. SON COMPUESTOS PREFERIDOS: ACIDO {4-(4-CLORO-3-FLUORO-FENIL)-2-[4-(ETILOXI)FENIL]-1,3-TIAZOL-5-IL}ACETICO, ACIDO {4-(4-CLORO-3-FLUORO-FENIL)-2-[4-(n-PROPILOXI)FENIL]-1,3-TIAZOL-5-IL}ACETICO, ACIDO {4-(4-CLORO-3-FLUORO-FENIL)-2-[4-(i-PROPILOXI)FENIL]-1,3-TIAZOL-5-IL}ACETICO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACETICA. DICHOS COMPUESTOS SON AGENTES DE APERTURA DE CANALES DE POTASIO ACTIVADOS POR CALCIO DE ALTA CONDUCTANCIA (CANALES BKCa) SIENDO UTILES EN EL TRATAMIENTO DE AFECCIONES URINARIAS TALES COMO VEJIGA HIPERACTIVAREFERS TO COMPOUNDS OF FORMULA (I) WHERE R1 IS ETHYL, PROPYL OR ISOPROPYL; R2 IS H, CHLORINE, FLUORINE, OR METHYL. THE PREFERRED COMPOUNDS ARE: {4- (4-CHLORO-3-FLUORO-PHENYL) -2- [4- (ETHYLOXY) PHENYL] -1,3-THIAZOL-5-IL} ACETIC ACID, {4- (4- CHLORO-3-FLUORO-PHENYL) -2- [4- (n-PROPYLOXY) PHENYL] -1,3-THIAZOL-5-IL} ACETIC ACID {4- (4-CHLORO-3-FLUORO-PHENYL) - 2- [4- (i-PROPYLOXY) PHENYL] -1,3-THIAZOL-5-IL} ACETIC, AMONG OTHERS. IT ALSO REFERS TO A PHARMACETICAL COMPOSITION. SAID COMPOUNDS ARE OPENING AGENTS OF POTASSIUM CHANNELS ACTIVATED BY HIGH CONDUCTANCE CALCIUM (BKCa CHANNELS) BEING USEFUL IN THE TREATMENT OF URINARY AFFECTIONS SUCH AS OVERACTIVE BLADDER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73029805P | 2005-10-26 | 2005-10-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20070530A1 true PE20070530A1 (en) | 2007-05-31 |
Family
ID=37968661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001294A PE20070530A1 (en) | 2005-10-26 | 2006-10-24 | COMPOUNDS DERIVED FROM THIAZOLS SUBSTITUTED AS OPENING AGENTS OF HIGH CONDUCTANCE ACTIVATED POTASSIUM CHANNELS |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR056720A1 (en) |
| PE (1) | PE20070530A1 (en) |
| TW (1) | TW200732314A (en) |
| WO (1) | WO2007051133A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575338B2 (en) | 2008-04-09 | 2013-11-05 | Mitsubishi Tanabe Pharma Corporation | Pyrimidine, pyridine and triazine derivatives as maxi-K channel openers |
| WO2022075780A1 (en) * | 2020-10-07 | 2022-04-14 | 광주과학기술원 | Pharmaceutical composition for preventing or treating overactive bladder |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4746741A (en) * | 1986-06-19 | 1988-05-24 | Eastman Kodak Company | N,N'-bis[2-(3-methylphenyl)ethyl]-perylene-3,4:9,10-bis (dicarboximide) compound use thereof in multi-active photoconductive insulating elements exhibiting far red sensitivity |
| IE73235B1 (en) * | 1991-03-25 | 1997-05-21 | Akzo Nv | 4-aryl-thiazole or imidazole derivatives |
| HU208429B (en) * | 1991-05-03 | 1993-10-28 | Gyogyszerkutato Intezet | Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity |
| US5668286A (en) * | 1994-03-15 | 1997-09-16 | Pharmacia & Upjohn Company | Oxazolidinone derivatives and pharmaceutical compositions containing them |
| AU2002246397B2 (en) * | 2001-04-16 | 2005-03-24 | Tanabe Seiyaku Co., Ltd. | Imidazole, thiazole and oxazole derivatives and their use for the manufacture of a medicament for the treatment and/or prevention of pollakiuria or urinary incontinence |
| GB0121033D0 (en) * | 2001-08-30 | 2001-10-24 | Novartis Ag | Organic compounds |
| US7057040B2 (en) * | 2002-02-07 | 2006-06-06 | Council Of Scientific And Industrial Research | Substituted aryl alkenoic acid heterocyclic amides |
-
2006
- 2006-10-24 PE PE2006001294A patent/PE20070530A1/en not_active Application Discontinuation
- 2006-10-24 AR ARP060104641A patent/AR056720A1/en not_active Application Discontinuation
- 2006-10-24 TW TW095139076A patent/TW200732314A/en unknown
- 2006-10-26 WO PCT/US2006/060248 patent/WO2007051133A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AR056720A1 (en) | 2007-10-17 |
| TW200732314A (en) | 2007-09-01 |
| WO2007051133A3 (en) | 2007-12-13 |
| WO2007051133A2 (en) | 2007-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |