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PE20061361A1 - Uso de derivados de 4-piridilmetil-ftalacina como inhibidores de vegf-r - Google Patents

Uso de derivados de 4-piridilmetil-ftalacina como inhibidores de vegf-r

Info

Publication number
PE20061361A1
PE20061361A1 PE2006000398A PE2006000398A PE20061361A1 PE 20061361 A1 PE20061361 A1 PE 20061361A1 PE 2006000398 A PE2006000398 A PE 2006000398A PE 2006000398 A PE2006000398 A PE 2006000398A PE 20061361 A1 PE20061361 A1 PE 20061361A1
Authority
PE
Peru
Prior art keywords
phthalkine
vegf
inhibitors
capillary
patients
Prior art date
Application number
PE2006000398A
Other languages
English (en)
Inventor
William Berg
David Lebwohl
Andrea Kay
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20061361A1 publication Critical patent/PE20061361A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE REFIERE AL USO DE INHIBIDORES DE RECEPTOR DE FACTOR DE CRECIMIENTO ENDOTELIAL VASCULAR (VEGF-R) TAL COMO UN DERIVADO DE 4-PIRIDILMETIL-FTALACINA DE FORMULA (I), SIENDO PREFERIDO EL COMPUESTO PTK787 O PTK/ZK O N-(4-CLOROFENIL)-4-(4-PIRIDINILMETIL)-FTALACINAMINA O TAMBIEN DENOMINADO VATALANIB, SOLO O EN COMBINACION CON AL MENOS UN COMPUESTO DE PLATINO TAL COMO OXALIPLATINA Y/O UN ANTIMETABOLITO ANTINEOPLASICO TAL COMO 5-FLUOROURACILO, CAPECITABINA Y OPCIONALMENTE ACIDO FOLINICO, ENTRE OTROS. PARA EL TRATAMIENTO DE PACIENTES CON CANCER GASTROINTESTINAL, GENITOURINARIO, LINFOIDE Y PULMONAR O CANCER DE ORIGEN CRESTA NEURAL, EN ESPECIAL CANCER COLORECTAL, A PACIENTES QUE TIENE ALTO VALORES DE LDH
PE2006000398A 2005-04-13 2006-04-17 Uso de derivados de 4-piridilmetil-ftalacina como inhibidores de vegf-r PE20061361A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67087005P 2005-04-13 2005-04-13
US68039605P 2005-05-12 2005-05-12

Publications (1)

Publication Number Publication Date
PE20061361A1 true PE20061361A1 (es) 2007-01-03

Family

ID=36649704

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000398A PE20061361A1 (es) 2005-04-13 2006-04-17 Uso de derivados de 4-piridilmetil-ftalacina como inhibidores de vegf-r

Country Status (6)

Country Link
AR (1) AR053576A1 (es)
GT (1) GT200600147A (es)
PE (1) PE20061361A1 (es)
TW (1) TW200719914A (es)
UY (1) UY29471A1 (es)
WO (1) WO2006113172A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0610925D0 (en) * 2006-06-02 2006-07-12 Novartis Ag Use of vascular endothelial growth factor receptor inhibitors for the treatment of cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO4950519A1 (es) * 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion

Also Published As

Publication number Publication date
GT200600147A (es) 2006-11-24
AR053576A1 (es) 2007-05-09
UY29471A1 (es) 2006-11-30
WO2006113172A1 (en) 2006-10-26
TW200719914A (en) 2007-06-01

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal