PE20061338A1 - Combinacion de antagonistas del receptor adrenergico alfa 1 o inhibidores de 5 alfa reductasa con inhibidores de pde 5 para la terapia de hiperplasia benigna de prostata - Google Patents
Combinacion de antagonistas del receptor adrenergico alfa 1 o inhibidores de 5 alfa reductasa con inhibidores de pde 5 para la terapia de hiperplasia benigna de prostataInfo
- Publication number
- PE20061338A1 PE20061338A1 PE2006000383A PE2006000383A PE20061338A1 PE 20061338 A1 PE20061338 A1 PE 20061338A1 PE 2006000383 A PE2006000383 A PE 2006000383A PE 2006000383 A PE2006000383 A PE 2006000383A PE 20061338 A1 PE20061338 A1 PE 20061338A1
- Authority
- PE
- Peru
- Prior art keywords
- alpha
- inhibitors
- pde
- adrenergic receptor
- benign prostate
- Prior art date
Links
- 229940123333 Phosphodiesterase 5 inhibitor Drugs 0.000 title abstract 3
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 title abstract 3
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 title abstract 2
- 102000030619 alpha-1 Adrenergic Receptor Human genes 0.000 title abstract 2
- 108020004102 alpha-1 Adrenergic Receptor Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000000674 adrenergic antagonist Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000005557 antagonist Substances 0.000 abstract 2
- 238000013270 controlled release Methods 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 101100296726 Caenorhabditis elegans pde-5 gene Proteins 0.000 abstract 1
- WNMJYKCGWZFFKR-UHFFFAOYSA-N alfuzosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(C)CCCNC(=O)C1CCCO1 WNMJYKCGWZFFKR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 abstract 1
- 229960001389 doxazosin Drugs 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 abstract 1
- 229960001693 terazosin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005016981A DE102005016981A1 (de) | 2005-04-13 | 2005-04-13 | Kombination zur Therapie bei benigner Prostatahyperplasie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20061338A1 true PE20061338A1 (es) | 2007-01-28 |
Family
ID=36608700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006000383A PE20061338A1 (es) | 2005-04-13 | 2006-04-11 | Combinacion de antagonistas del receptor adrenergico alfa 1 o inhibidores de 5 alfa reductasa con inhibidores de pde 5 para la terapia de hiperplasia benigna de prostata |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1888075A1 (fr) |
| JP (1) | JP2008535877A (fr) |
| KR (1) | KR20080007252A (fr) |
| CN (1) | CN101193638A (fr) |
| AR (1) | AR053575A1 (fr) |
| AU (1) | AU2006233567A1 (fr) |
| BR (1) | BRPI0610634A2 (fr) |
| CA (1) | CA2605224A1 (fr) |
| CR (1) | CR9427A (fr) |
| DE (1) | DE102005016981A1 (fr) |
| DO (1) | DOP2006000074A (fr) |
| GT (1) | GT200600145A (fr) |
| IL (1) | IL186604A0 (fr) |
| MA (1) | MA29683B1 (fr) |
| MX (1) | MX2007012567A (fr) |
| PE (1) | PE20061338A1 (fr) |
| RU (1) | RU2007141518A (fr) |
| SV (1) | SV2008002477A (fr) |
| TN (1) | TNSN07385A1 (fr) |
| TW (1) | TW200716122A (fr) |
| UY (1) | UY29473A1 (fr) |
| WO (1) | WO2006108519A1 (fr) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143746A (en) * | 1994-01-21 | 2000-11-07 | Icos Corporation | Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use |
| US20070093493A1 (en) * | 2005-10-12 | 2007-04-26 | Lilly Icos Llc | Treatment of benign prostatic hypertrophy and lower urinary tract symptoms |
| CA2633570A1 (fr) * | 2005-12-21 | 2007-06-28 | Pfizer Products Inc. | Combinaison pharmaceutique d'un inhibiteur de pde-5 et d'un inhibiteur de 5-alpha reductase |
| BRPI0621852A2 (pt) * | 2006-07-07 | 2011-12-20 | Teva Pharma | compostos sólidos consistindo de tadalafil e pelo menos um veìculo |
| DE102007028869A1 (de) | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
| HRP20140701T1 (hr) | 2007-12-13 | 2014-11-21 | Vanda Pharmaceuticals Inc. | Metoda i spoj za lijeäśenje stanja posredovanih serotoninskim receptorom |
| US8729100B2 (en) | 2007-12-13 | 2014-05-20 | Vanda Pharmaceuticals, Inc. | Method and composition for treating an alpha adrenoceptor-mediated condition |
| US8654746B2 (en) | 2010-04-26 | 2014-02-18 | Intel Corporation | Method, apparatus and system for fast session transfer for multiple frequency band wireless communication |
| WO2013123965A1 (fr) * | 2012-02-20 | 2013-08-29 | Synthon Bv | Formulation pharmaceutique à dose fixe |
| CN102727456B (zh) * | 2012-07-03 | 2016-06-22 | 北京科信必成医药科技发展有限公司 | 药物口腔崩解片及其制备方法 |
| WO2014209087A1 (fr) * | 2013-06-28 | 2014-12-31 | Hanmi Pharm. Co., Ltd. | Préparation composite pour gélule pharmaceutique comprenant du tadalafil et de la tamsulosine |
| CN105579057A (zh) | 2013-07-23 | 2016-05-11 | 阿勒根公司 | 包含与β-3-肾上腺素能受体激动剂组合的去氨加压素的方法和组合物 |
| KR101663238B1 (ko) * | 2013-11-15 | 2016-10-14 | 한미약품 주식회사 | 타다라필 및 암로디핀을 포함하는 복합 고형 제제 |
| BR112016030731A2 (pt) * | 2014-06-30 | 2017-08-22 | Hanmi Pharm Ind Co Ltd | Preparação de compósito, e, método de preparação de uma preparação de compósito |
| MY181172A (en) * | 2014-06-30 | 2020-12-21 | Hanmi Pharm Ind Co Ltd | Composite preparation comprising active ingredient-containing film coating layer |
| PH12016502537B1 (en) * | 2014-06-30 | 2022-11-04 | Hanmi Pharmaceutical Co Ltd | Composite preparation comprising active ingredient-containing film coating layer |
| JP2017535567A (ja) * | 2014-11-20 | 2017-11-30 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | アルファ−アドレナリン受容体拮抗薬と組み合わせたデスモプレシンを含む方法及び組成物 |
| ES2933177T3 (es) * | 2016-03-31 | 2023-02-02 | Hanmi Pharm Ind Co Ltd | Preparación de cápsulas compuestas, que contienen tadalafilo y tamsulosina, y que tienen una estabilidad y una tasa de elución mejoradas |
| KR101835506B1 (ko) * | 2016-10-25 | 2018-03-07 | 주식회사 에스텍파마 | 두타스테리드와 타다라필을 함유하는 속효성 복합정제 |
| CN108066347B (zh) * | 2016-11-16 | 2021-02-02 | 深圳万和制药有限公司 | 包含坦索罗辛和度他雄胺的口腔崩解片药物组合物 |
| KR101879133B1 (ko) * | 2017-07-11 | 2018-07-17 | (주)동구바이오제약 | 비뇨기 질환 예방 또는 치료용 제제 및 이의 제조방법 |
| TR201715231A2 (tr) * | 2017-10-09 | 2019-04-22 | Montero Gida Sanayi Ve Ticaret Anonim Sirketi | Dapokseti̇n ve fosfodi̇esteraz ti̇p-5 i̇nhi̇bi̇törü i̇çeren farmasöti̇k kombi̇nasyon |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050042177A1 (en) * | 2003-07-23 | 2005-02-24 | Elan Pharma International Ltd. | Novel compositions of sildenafil free base |
-
2005
- 2005-04-13 DE DE102005016981A patent/DE102005016981A1/de not_active Withdrawn
-
2006
- 2006-03-29 DO DO2006000074A patent/DOP2006000074A/es unknown
- 2006-03-31 KR KR1020077026260A patent/KR20080007252A/ko not_active Withdrawn
- 2006-03-31 RU RU2007141518/15A patent/RU2007141518A/ru unknown
- 2006-03-31 MX MX2007012567A patent/MX2007012567A/es not_active Application Discontinuation
- 2006-03-31 JP JP2008505765A patent/JP2008535877A/ja active Pending
- 2006-03-31 EP EP06723901A patent/EP1888075A1/fr not_active Withdrawn
- 2006-03-31 BR BRPI0610634-0A patent/BRPI0610634A2/pt not_active Application Discontinuation
- 2006-03-31 WO PCT/EP2006/002941 patent/WO2006108519A1/fr not_active Ceased
- 2006-03-31 AU AU2006233567A patent/AU2006233567A1/en not_active Abandoned
- 2006-03-31 CA CA002605224A patent/CA2605224A1/fr not_active Abandoned
- 2006-03-31 CN CNA2006800207814A patent/CN101193638A/zh active Pending
- 2006-04-07 SV SV2006002477A patent/SV2008002477A/es not_active Application Discontinuation
- 2006-04-10 GT GT200600145A patent/GT200600145A/es unknown
- 2006-04-11 AR ARP060101410A patent/AR053575A1/es unknown
- 2006-04-11 PE PE2006000383A patent/PE20061338A1/es not_active Application Discontinuation
- 2006-04-12 UY UY29473A patent/UY29473A1/es not_active Application Discontinuation
- 2006-04-12 TW TW095112920A patent/TW200716122A/zh unknown
-
2007
- 2007-10-09 CR CR9427A patent/CR9427A/es not_active Application Discontinuation
- 2007-10-11 IL IL186604A patent/IL186604A0/en unknown
- 2007-10-11 TN TNP2007000385A patent/TNSN07385A1/en unknown
- 2007-10-29 MA MA30335A patent/MA29683B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR053575A1 (es) | 2007-05-09 |
| MX2007012567A (es) | 2007-12-10 |
| DE102005016981A1 (de) | 2006-10-19 |
| MA29683B1 (fr) | 2008-08-01 |
| KR20080007252A (ko) | 2008-01-17 |
| GT200600145A (es) | 2007-04-10 |
| CN101193638A (zh) | 2008-06-04 |
| UY29473A1 (es) | 2006-11-30 |
| SV2008002477A (es) | 2008-02-08 |
| RU2007141518A (ru) | 2009-05-20 |
| TW200716122A (en) | 2007-05-01 |
| JP2008535877A (ja) | 2008-09-04 |
| CR9427A (es) | 2007-12-17 |
| AU2006233567A1 (en) | 2006-10-19 |
| CA2605224A1 (fr) | 2006-10-19 |
| IL186604A0 (en) | 2008-01-20 |
| EP1888075A1 (fr) | 2008-02-20 |
| BRPI0610634A2 (pt) | 2010-07-13 |
| WO2006108519A1 (fr) | 2006-10-19 |
| DOP2006000074A (es) | 2006-10-15 |
| TNSN07385A1 (en) | 2009-03-17 |
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