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PE20061040A1 - Anticuerpos antiamiloides humanizados - Google Patents

Anticuerpos antiamiloides humanizados

Info

Publication number
PE20061040A1
PE20061040A1 PE2006000102A PE2006000102A PE20061040A1 PE 20061040 A1 PE20061040 A1 PE 20061040A1 PE 2006000102 A PE2006000102 A PE 2006000102A PE 2006000102 A PE2006000102 A PE 2006000102A PE 20061040 A1 PE20061040 A1 PE 20061040A1
Authority
PE
Peru
Prior art keywords
seq
humanized
amino acid
antibodies
antiamylloid
Prior art date
Application number
PE2006000102A
Other languages
English (en)
Inventor
Shen Wenyan
Biere-Citron Anja Leona
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of PE20061040A1 publication Critical patent/PE20061040A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

REFERIDA A UN AGENTE DE UNION ESPECIFICO AISLADO QUE SE UNE AL BETA - AMILOIDE, QUE COMPRENDE UNA SECUENCIA DE AMINOACIDOS AL MENOS 80% IDENTICA A LA SECUENCIA DE AMINOACIDOS ESTABLECIDA EN SEQ ID NO: 11; ADEMAS, PUEDE COMPRENDER LAS SECUENCIAS DE AMINOACIDOS DE SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NOS. 12, 13 O 14, ENTRE OTRAS. DICHOS AGENTES DE UNION ESPECIFICOS SON ANTICUERPOS MONOCLONALES HUMANOS O HUMANIZADOS (NO MURINOS) QUE SE UNEN AL BETA - AMILOIDE Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS NEURODEGENERATIVOS O AMILOIDOGENICOS TALES COMO LA ENFERMEDAD DE ALZHEIMER
PE2006000102A 2005-01-24 2006-01-24 Anticuerpos antiamiloides humanizados PE20061040A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64665805P 2005-01-24 2005-01-24

Publications (1)

Publication Number Publication Date
PE20061040A1 true PE20061040A1 (es) 2006-10-12

Family

ID=36463459

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006000102A PE20061040A1 (es) 2005-01-24 2006-01-24 Anticuerpos antiamiloides humanizados

Country Status (8)

Country Link
US (1) US7906625B2 (es)
EP (1) EP1841455A1 (es)
AU (1) AU2006208226A1 (es)
CA (1) CA2589860A1 (es)
PA (1) PA8660801A1 (es)
PE (1) PE20061040A1 (es)
UY (1) UY29344A1 (es)
WO (1) WO2006081171A1 (es)

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