PE20060127A1 - Sistema de entrega de farmacos constituido por copolimero de polietileno acetato de vinilo - Google Patents
Sistema de entrega de farmacos constituido por copolimero de polietileno acetato de viniloInfo
- Publication number
- PE20060127A1 PE20060127A1 PE2005000327A PE2005000327A PE20060127A1 PE 20060127 A1 PE20060127 A1 PE 20060127A1 PE 2005000327 A PE2005000327 A PE 2005000327A PE 2005000327 A PE2005000327 A PE 2005000327A PE 20060127 A1 PE20060127 A1 PE 20060127A1
- Authority
- PE
- Peru
- Prior art keywords
- drug delivery
- delivery system
- compartment
- copolymer
- vinyl acetate
- Prior art date
Links
- -1 POLYETHYLENE COPOLYMER Polymers 0.000 title abstract 3
- 239000004698 Polyethylene Substances 0.000 title abstract 3
- 229920000573 polyethylene Polymers 0.000 title abstract 3
- 238000012377 drug delivery Methods 0.000 title abstract 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229920001577 copolymer Polymers 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 abstract 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 1
- 208000019802 Sexually transmitted disease Diseases 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 229960002568 ethinylestradiol Drugs 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical class C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229920001169 thermoplastic Polymers 0.000 abstract 1
- 239000004416 thermosoftening plastic Substances 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical class C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UN SISTEMA DE ENTREGA DE FARMACOS, CARACTERIZADO POR: A) SI TIENE UN COMPARTIMIENTO, ESTA COMPRENDIDO POR: i) UN NUCLEO DE UN COPOLIMERO DE POLIETILENOACETATO DE VINILO TERMOPLASTICO, QUE COMPRENDE EL COMPUESTO PROGESTAGENO ESTEROIDAL COMO ETONOGESTREL, EL CUAL ESTA DISUELTO EN EL COPOLIMERO DE POLIETILENO, HASTA UNA CONCENTRACION INFERIOR AL NIVEL DE SATURACION A 25°C, Y UN COMPUESTO ESTROGENICO COMO ETINIL ESTRADIOL Y ii) UN FORRO DEL MISMO COPOLIMERO, QUE CUBRE EL NUCLEO Y ES PERMEABLE PARA AMBOS COMPUESTOS, CON UN ESPESOR DE 70 A 250 um; B) SI ESTA CONFORMADO POR MAS DE UN COMPARTIMIENTO, SOLO UN COMPARTIMIENTO ESTARA CONFORMADO POR LOS ELEMENTOS ANTERIORES. TAMBIEN SE REFIRE A UN PROCESO DE FABRICACION . ESTE SISTEMA SE PRESENTA BAJO LA FORMA DE ANILLO DE USO INTRAVAGINAL Y SE UTILIZA PARA LA FABRICACION DE UN KIT O DE UNA PREPARACION COMBINADA PARA ANTICONCEPCION Y/O PREVENCION DE UNA ENFERMEDAD DE TRANSMICION SEXUAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04101215 | 2004-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060127A1 true PE20060127A1 (es) | 2006-03-15 |
Family
ID=34928924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005000327A PE20060127A1 (es) | 2004-03-24 | 2005-03-22 | Sistema de entrega de farmacos constituido por copolimero de polietileno acetato de vinilo |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8481079B2 (es) |
| EP (1) | EP1732520B1 (es) |
| JP (1) | JP2007530500A (es) |
| CN (1) | CN100531800C (es) |
| AR (1) | AR048185A1 (es) |
| AT (1) | ATE434433T1 (es) |
| AU (1) | AU2005224056B2 (es) |
| BR (1) | BRPI0509146B8 (es) |
| CA (1) | CA2559224C (es) |
| DE (1) | DE602005015090D1 (es) |
| ES (1) | ES2327247T3 (es) |
| IL (1) | IL178018A (es) |
| MX (1) | MXPA06010905A (es) |
| MY (1) | MY142824A (es) |
| PE (1) | PE20060127A1 (es) |
| TW (1) | TWI290837B (es) |
| WO (1) | WO2005089723A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1629844T4 (da) | 2004-07-13 | 2012-05-29 | Bayer Schering Pharma Oy | Retarderet indgivelsessystem med kontrolleret initialudbrud |
| KR20090083922A (ko) * | 2006-11-20 | 2009-08-04 | 엔.브이.오가논 | 나선형 약물 전달 시스템 |
| EP2094348A1 (en) * | 2006-11-22 | 2009-09-02 | N.V. Organon | Delivery system for a non-steroidal non-ionized hydrophilic drug |
| US8741329B2 (en) * | 2007-09-21 | 2014-06-03 | Merck Sharp & Dohme B.V. | Drug delivery system |
| TW200927141A (en) * | 2007-11-22 | 2009-07-01 | Bayer Schering Pharma Oy | Vaginal delivery system |
| EP2062568A1 (en) * | 2007-11-22 | 2009-05-27 | Bayer Schering Pharma Oy | Vaginal delivery system |
| DK2062569T3 (da) * | 2007-11-22 | 2011-08-29 | Bayer Oy | Vaginalt afgivelsessystem |
| WO2010105995A2 (en) | 2009-03-17 | 2010-09-23 | Intervet International B.V. | Zoo-technical drug delivery device |
| KR20120006987A (ko) * | 2009-03-17 | 2012-01-19 | 인터벳 인터내셔널 비.브이. | 마크로시클릭 락톤 약물 전달 시스템 |
| AU2011238710B2 (en) * | 2010-03-28 | 2015-08-20 | Evestra, Inc. | Intravaginal drug delivery device |
| US8580294B2 (en) | 2010-10-19 | 2013-11-12 | International Partnership For Microbicides | Platinum-catalyzed intravaginal rings |
| CN104168902A (zh) | 2011-08-26 | 2014-11-26 | 智利圣地亚哥大学 | 阴道内给药非类固醇抗炎药物美洛昔康和吡罗昔康用于中断女性排卵过程的用途 |
| TW201332585A (zh) | 2012-02-14 | 2013-08-16 | Chemo Res S L | 核鞘藥物遞送裝置 |
| EP2893804B1 (en) | 2012-09-03 | 2018-03-21 | Ecosea Farming S.A. | Reservoir-cage submersion system for the culture and/or containment of hydrobiological species |
| US10137031B2 (en) | 2013-11-14 | 2018-11-27 | International Partnership For Microbicides, Inc. | Combination therapy intravaginal rings |
| US10596103B2 (en) | 2013-12-11 | 2020-03-24 | Merek Sharp & Dohme B.V. | Drug delivery system for delivery of anti-virals |
| US10413504B2 (en) * | 2013-12-11 | 2019-09-17 | Merck Sharp & Dohme Corp. | Intravaginal ring drug delivery system |
| CN104306380A (zh) * | 2014-09-18 | 2015-01-28 | 新疆特丰药业股份有限公司 | 结合雌激素和醋酸甲羟孕酮双层片及其制备方法 |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| US10406336B2 (en) | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
| EP3395335A1 (en) * | 2017-04-24 | 2018-10-31 | Kern Pharma, S.L. | Vaginal ring for the simultaneous release of two active ingredients |
| CA3087238A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| WO2019226519A1 (en) | 2018-05-24 | 2019-11-28 | Celanese EVA Performance Polymers Corporation | Implantable device for sustained release of a macromolecular drug compound |
| EP3803866A4 (en) | 2018-05-24 | 2022-03-16 | Nureva Inc. | METHOD, APPARATUS, AND COMPUTER READABLE MATERIALS FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE CATCH/HOME AREAS |
| CA3122847A1 (en) * | 2018-12-11 | 2020-06-18 | Lupin Inc. | Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof |
| US11439588B2 (en) * | 2019-10-12 | 2022-09-13 | National Research Institute For Family Planning | Vaginal sustained-release drug delivery system for luteal support, method for preparation and use thereof |
| KR102159904B1 (ko) | 2020-04-24 | 2020-09-24 | 강경원 | 약물 방출 고리를 구비한 월경컵 |
| EP4329734A4 (en) | 2021-04-26 | 2025-04-02 | Celanese EVA Performance Polymers LLC | Implantable device for the delayed release of a macromolecular drug compound |
| WO2023200974A1 (en) * | 2022-04-14 | 2023-10-19 | Yale University | Nanoparticles and nanoparticle-releasing vaginal rings |
| WO2024030116A1 (en) * | 2022-08-01 | 2024-02-08 | Lupin Inc. | Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3995634A (en) * | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal cavity dispensing means and method |
| US3995633A (en) * | 1975-12-02 | 1976-12-07 | The Procter & Gamble Company | Vaginal Medicament dispensing device |
| US4237885A (en) * | 1978-10-23 | 1980-12-09 | Alza Corporation | Delivery system with mated members for storing and releasing a plurality of beneficial agents |
| US4292965A (en) * | 1978-12-29 | 1981-10-06 | The Population Council, Inc. | Intravaginal ring |
| DE3040978A1 (de) | 1980-10-28 | 1982-05-27 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Vaginalring |
| US4596576A (en) * | 1984-10-12 | 1986-06-24 | Akzo N.V. | Release system for two or more active substances |
| WO1997002015A1 (en) | 1995-07-04 | 1997-01-23 | Akzo Nobel N.V. | Ring-shaped devices |
| TW358031B (en) * | 1997-04-11 | 1999-05-11 | Akze Nobel N V | Drug delivery system for 2 or more active substances |
| IL136307A (en) | 1997-12-12 | 2004-03-28 | Akzo Nobel Nv | Packing for holster ring |
-
2005
- 2005-03-16 AT AT05717059T patent/ATE434433T1/de not_active IP Right Cessation
- 2005-03-16 JP JP2007504403A patent/JP2007530500A/ja not_active Withdrawn
- 2005-03-16 WO PCT/EP2005/051189 patent/WO2005089723A1/en not_active Ceased
- 2005-03-16 CN CNB2005800093236A patent/CN100531800C/zh not_active Expired - Fee Related
- 2005-03-16 MX MXPA06010905A patent/MXPA06010905A/es active IP Right Grant
- 2005-03-16 CA CA2559224A patent/CA2559224C/en not_active Expired - Lifetime
- 2005-03-16 US US10/594,104 patent/US8481079B2/en not_active Expired - Lifetime
- 2005-03-16 TW TW094108065A patent/TWI290837B/zh not_active IP Right Cessation
- 2005-03-16 BR BRPI0509146A patent/BRPI0509146B8/pt not_active IP Right Cessation
- 2005-03-16 EP EP05717059A patent/EP1732520B1/en not_active Expired - Lifetime
- 2005-03-16 ES ES05717059T patent/ES2327247T3/es not_active Expired - Lifetime
- 2005-03-16 AU AU2005224056A patent/AU2005224056B2/en not_active Ceased
- 2005-03-16 DE DE602005015090T patent/DE602005015090D1/de not_active Expired - Lifetime
- 2005-03-22 PE PE2005000327A patent/PE20060127A1/es not_active Application Discontinuation
- 2005-03-23 AR ARP050101144A patent/AR048185A1/es unknown
- 2005-03-24 MY MYPI20051277A patent/MY142824A/en unknown
-
2006
- 2006-09-11 IL IL178018A patent/IL178018A/en not_active IP Right Cessation
-
2013
- 2013-06-05 US US13/910,250 patent/US8808744B2/en not_active Expired - Lifetime
-
2014
- 2014-06-23 US US14/312,034 patent/US20140302115A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005224056B2 (en) | 2010-03-18 |
| IL178018A (en) | 2010-05-17 |
| TWI290837B (en) | 2007-12-11 |
| CA2559224C (en) | 2011-12-13 |
| TW200536572A (en) | 2005-11-16 |
| EP1732520A1 (en) | 2006-12-20 |
| JP2007530500A (ja) | 2007-11-01 |
| IL178018A0 (en) | 2006-12-31 |
| BRPI0509146B1 (pt) | 2018-03-20 |
| CN100531800C (zh) | 2009-08-26 |
| EP1732520B1 (en) | 2009-06-24 |
| AR048185A1 (es) | 2006-04-05 |
| CN1933820A (zh) | 2007-03-21 |
| AU2005224056A1 (en) | 2005-09-29 |
| MXPA06010905A (es) | 2007-03-08 |
| BRPI0509146A (pt) | 2007-09-04 |
| WO2005089723A1 (en) | 2005-09-29 |
| BRPI0509146B8 (pt) | 2021-05-25 |
| ES2327247T3 (es) | 2009-10-27 |
| DE602005015090D1 (de) | 2009-08-06 |
| US20070141102A1 (en) | 2007-06-21 |
| MY142824A (en) | 2011-01-14 |
| US8481079B2 (en) | 2013-07-09 |
| ATE434433T1 (de) | 2009-07-15 |
| US8808744B2 (en) | 2014-08-19 |
| US20130266632A1 (en) | 2013-10-10 |
| US20140302115A1 (en) | 2014-10-09 |
| CA2559224A1 (en) | 2005-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |