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PE20060623A1 - Compuestos de sulfonamida como potenciadores del receptor de glutamato - Google Patents

Compuestos de sulfonamida como potenciadores del receptor de glutamato

Info

Publication number
PE20060623A1
PE20060623A1 PE2005000909A PE2005000909A PE20060623A1 PE 20060623 A1 PE20060623 A1 PE 20060623A1 PE 2005000909 A PE2005000909 A PE 2005000909A PE 2005000909 A PE2005000909 A PE 2005000909A PE 20060623 A1 PE20060623 A1 PE 20060623A1
Authority
PE
Peru
Prior art keywords
glutamate receptor
sulfonamide compounds
propanosulfonamide
inden
pyridinyl
Prior art date
Application number
PE2005000909A
Other languages
English (en)
Inventor
Daniel Marcus Bradley
Kevin Michael Thewlis
Simon Edward Ward
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0417708A external-priority patent/GB0417708D0/en
Priority claimed from GB0508473A external-priority patent/GB0508473D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20060623A1 publication Critical patent/PE20060623A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE SULFONAMIDA DE FORMULA I, DONDE R1 ES ALQUILO C1-C6, ALQUENILO C2-C6, AMINO, ENTRE OTROS; R4 ES HALOGENO, CIANO, AMINO, ENTRE OTROS; p ES 0, 1 O 2; n ES 1 O 2; R5 Y R6 SON H, HALOGENO, ALQUILO C1-C6, ENTRE OTROS; HET ES TIENILO, PIRIDILO, PIRIMIDINILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[5-(2-FLUORO-3-PIRIDINIL)-2,3-DIHIDRO-1H-INDEN-2-IL]-2-PROPANOSULFONAMIDA, N-[5-(6-FLUORO-3-PIRIDINIL)-2,3-DIHIDRO-1H-INDEN-2-IL]-2-PROPANOSULFONAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS POTENCIAN AL RECEPTOR DE GLUTAMATO Y SON UTILES EN EL TRATAMIENTO DE TRASTORNOS PSICOTICOS, ALTERACION COGNITIVA, PSICOSIS, ENTRE OTRAS
PE2005000909A 2004-08-09 2005-08-05 Compuestos de sulfonamida como potenciadores del receptor de glutamato PE20060623A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0417708A GB0417708D0 (en) 2004-08-09 2004-08-09 Compounds
GB0508473A GB0508473D0 (en) 2005-04-26 2005-04-26 Compounds

Publications (1)

Publication Number Publication Date
PE20060623A1 true PE20060623A1 (es) 2006-07-01

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Application Number Title Priority Date Filing Date
PE2005000909A PE20060623A1 (es) 2004-08-09 2005-08-05 Compuestos de sulfonamida como potenciadores del receptor de glutamato

Country Status (21)

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US (2) US7618969B2 (es)
EP (2) EP1944289B1 (es)
JP (1) JP4901735B2 (es)
KR (1) KR20070050070A (es)
CN (1) CN101035760B (es)
AR (1) AR050208A1 (es)
AT (2) ATE468326T1 (es)
AU (1) AU2005270377A1 (es)
BR (1) BRPI0514191A (es)
CA (1) CA2576254A1 (es)
DE (2) DE602005015119D1 (es)
ES (2) ES2346017T3 (es)
IL (1) IL181172A0 (es)
MA (1) MA28823B1 (es)
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4901735B2 (ja) * 2004-08-09 2012-03-21 グラクソ グループ リミテッド グルタミン酸受容体を強化する化合物および医学におけるその使用
KR100659088B1 (ko) * 2005-07-15 2006-12-21 삼성에스디아이 주식회사 디플루오로피리딘계 화합물 및 이를 이용한 유기 발광 소자
AR059961A1 (es) 2006-03-20 2008-05-14 Glaxo Group Ltd Compuesto derivado de fenil tetrahidro-indazol, composiciones farmaceuticas que lo comprenden, usos para preparar un medicamento para el tratamiento de una enfermedad mediada por una reduccion o desequilibrio en la funcion del receptor de glutamato y procesos para su preparacion
ATE502675T1 (de) 2006-11-03 2011-04-15 Glaxo Group Ltd Verbindungen, die den ampa-rezeptor verstärken, und deren anwendung in der medizin
GB0704939D0 (en) * 2007-03-14 2007-04-25 Glaxo Group Ltd Compounds
WO2008113795A1 (en) * 2007-03-20 2008-09-25 Glaxo Group Limited Compounds which potentiate ampa receptor and uses thereof in medicine
GB0711088D0 (en) * 2007-06-08 2007-07-18 Glaxo Group Ltd Compounds
GB0711089D0 (en) * 2007-06-08 2007-07-18 Glaxo Group Ltd Compounds
UY31544A1 (es) 2007-12-19 2009-07-17 Compuestos que potencian el receptor de ampa y usos de los mismos en medicina
TW201012803A (en) * 2008-06-06 2010-04-01 Organon Nv Heterocyclic derivatives
GB0818071D0 (en) * 2008-10-02 2008-11-05 Glaxo Group Ltd Compounds
GB0821166D0 (en) * 2008-11-19 2008-12-24 Glaxo Group Ltd Compounds
GB0822425D0 (en) * 2008-12-09 2009-01-14 Glaxo Group Ltd Compounds
CA2758105A1 (en) * 2009-04-09 2010-10-14 N.V. Organon Indane derivatives
EP2694472B1 (en) 2011-04-05 2020-03-11 Takeda Pharmaceutical Company Limited Sulfonamide derivative and use thereof
EP2784065B1 (en) 2011-11-22 2016-10-05 Beijing Medisan Technology Co. Ltd. Glycine reuptake inhibitor and use thereof
MX2015017253A (es) 2013-06-13 2016-04-19 Veroscience Llc Composiciones y metodos para tratar trastornos metabolicos.
WO2016092547A1 (en) * 2014-12-09 2016-06-16 Ezekiel Golan Alcoholic beverage substitutes
CN112500301B (zh) 2014-12-09 2024-02-13 以西结·戈兰 放纵行为调节剂
GB201601301D0 (en) * 2016-01-25 2016-03-09 Takeda Pharmaceutical Novel compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07233072A (ja) * 1993-12-28 1995-09-05 Tanabe Seiyaku Co Ltd 医薬組成物
US6552086B1 (en) * 1998-07-31 2003-04-22 Eli Lilly And Company Sulfonamide derivatives
PE20000944A1 (es) * 1998-07-31 2000-09-20 Lilly Co Eli Derivados de sulfonamida
TW593241B (en) * 1999-04-20 2004-06-21 Hoffmann La Roche Carbamic acid derivatives
NZ530385A (en) * 1999-04-30 2004-05-28 Lilly Co Eli Monofluoroalkyl derivatives
US6703425B2 (en) * 2000-06-13 2004-03-09 Eli Lilly And Company Sulfonamide derivatives
EP1395550B1 (en) * 2001-05-30 2005-06-29 Eli Lilly And Company Cycloalkenylsulfonamide derivatives
JP4901735B2 (ja) * 2004-08-09 2012-03-21 グラクソ グループ リミテッド グルタミン酸受容体を強化する化合物および医学におけるその使用

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BRPI0514191A (pt) 2008-06-03
US20070161638A1 (en) 2007-07-12
US7572819B2 (en) 2009-08-11
CN101035760B (zh) 2011-03-02
RU2007108536A (ru) 2008-09-20
KR20070050070A (ko) 2007-05-14
US7618969B2 (en) 2009-11-17
ATE434608T1 (de) 2009-07-15
US20080194648A1 (en) 2008-08-14
TW200619197A (en) 2006-06-16
ATE468326T1 (de) 2010-06-15
NO20071234L (no) 2007-05-08
NZ552979A (en) 2010-02-26
EP1944289A1 (en) 2008-07-16
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MX2007001678A (es) 2007-04-12
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CA2576254A1 (en) 2006-02-16
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EP1781614B1 (en) 2009-06-24
AU2005270377A1 (en) 2006-02-16
CN101035760A (zh) 2007-09-12
MA28823B1 (fr) 2007-08-01
DE602005021407D1 (de) 2010-07-01
AR050208A1 (es) 2006-10-04
WO2006015828A1 (en) 2006-02-16
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