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PE20060457A1 - Derivados de difenil eter como antagonistas de los receptores 5ht2 - Google Patents

Derivados de difenil eter como antagonistas de los receptores 5ht2

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Publication number
PE20060457A1
PE20060457A1 PE2005001039A PE2005001039A PE20060457A1 PE 20060457 A1 PE20060457 A1 PE 20060457A1 PE 2005001039 A PE2005001039 A PE 2005001039A PE 2005001039 A PE2005001039 A PE 2005001039A PE 20060457 A1 PE20060457 A1 PE 20060457A1
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PE
Peru
Prior art keywords
alkyl
antagonists
diphenyl ether
receptors
ether derivatives
Prior art date
Application number
PE2005001039A
Other languages
English (en)
Inventor
Michelle Marie Claffey
Anton Franz Josef Fliri
Randall James Gallaschun
Christopher John O'donnell
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20060457A1 publication Critical patent/PE20060457A1/es

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Abstract

REFERIDA A UN COMPUESTO DERIVADO DE DIFENIL ETER DE FORMULAS Ia, Ib Y Ic, DONDE X E Y SON O, O(CH2)n, S, N, ENTRE OTROS; R1, R2 Y R3 SON H O CH3; R4 ES H, F, Cl O CH3; R5 ES F, ALQUILO C1-C6, ENTRE OTROS; R6 ES H, CN, ALQUILO C1-C6, ENTRE OTROS; R7 ES H, F, ALQUILO C1-C6, ENTRE OTROS; R8 ES H, F, ALQUILO C1-C6, ENTRE OTROS; R9 ES H, CH3, OH, ENTRE OTROS; R10 ES H, F, ALQUILO C1-C6, ENTRE OTROS; R11 Y R12 SON H, OH, ALQUILO C1-C6, ENTRE OTROS; R13, R15, R16 Y R17 SON H O ALQUILO C1-C6; R14 ES H, CH3, OH, ENTRE OTROS; k ES 1 O 2; m, u Y v SON 0, 1 O 2; n, p, q, r, s Y t SON 0, 1, 2, 3, 4, 5 O 6; LA LINEA DE PUNTOS REPRESENTA UN DOBLE ENLACE OPCIONAL. SON COMPUESTOS PREFERIDOS: 3-(5-CLORO-4-FLUORO-2-METILAMINOMETILFENOXI)-2-METILFENOL; [4-BROMO-2-(3-METOXI-2-METILFENOXI)BENCIL]METILAMINA, 2-[3-(METOXI-2-METIFENOXI)-4-METIAMINOMETILFENIL]PROPAN-2-OL, ENTRE OTROS. TAMBIEN ESTA REFERIDA A COMPOSICIONES FARMACEUTICAS. DICHOS COMPUESTOS SON LIGANDOS DE LOS RECEPTORES DE SEROTONINA 5HT, PARTICULARMENTE SON ANTAGONISTAS DE 5HT2, INCLUYENDO LOS SUBTIPOS 5HT2A Y 5HT2C Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL Y OTROS RELACIONADOS CON RECEPTORES 5HT
PE2005001039A 2004-09-10 2005-09-08 Derivados de difenil eter como antagonistas de los receptores 5ht2 PE20060457A1 (es)

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US60899404P 2004-09-10 2004-09-10
US69917505P 2005-07-14 2005-07-14

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US (1) US20060058361A1 (es)
EP (1) EP1791807A1 (es)
JP (1) JP2008512438A (es)
AR (1) AR050798A1 (es)
BR (1) BRPI0514675A (es)
CA (1) CA2580024A1 (es)
GT (1) GT200500253A (es)
MX (1) MX2007002732A (es)
NL (1) NL1029919C2 (es)
PE (1) PE20060457A1 (es)
SV (1) SV2007002226A (es)
TW (1) TW200613255A (es)
UY (1) UY29108A1 (es)
WO (1) WO2006027684A1 (es)

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CN105250316B (zh) * 2015-11-14 2018-01-19 西安力邦制药有限公司 一种含二联苯酚的抗癫痫药物组合
CN109819653A (zh) * 2016-08-16 2019-05-28 拜耳作物科学股份公司 制备2-(3,6-二卤代吡啶-2-基)-3H-咪唑[4,5-c]吡啶衍生物的方法以及通过3H-咪唑[4,5-c]吡啶衍生物与有机金属锌胺碱的反应得到的相关化合物
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KR20030029889A (ko) * 2000-08-31 2003-04-16 화이자 인코포레이티드 선택적 세로토닌 재흡수 억제제인 페녹시벤질아민 유도체
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EP1260221A3 (en) * 2001-05-23 2002-12-18 Pfizer Products Inc. Combination treatment for depression and anxiety

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TW200613255A (en) 2006-05-01
GT200500253A (es) 2006-04-17
CA2580024A1 (en) 2006-03-16
AR050798A1 (es) 2006-11-22
NL1029919C2 (nl) 2006-10-12
JP2008512438A (ja) 2008-04-24
EP1791807A1 (en) 2007-06-06
UY29108A1 (es) 2006-04-28
WO2006027684A1 (en) 2006-03-16
NL1029919A1 (nl) 2006-03-13
US20060058361A1 (en) 2006-03-16
BRPI0514675A (pt) 2008-06-17
SV2007002226A (es) 2007-03-20

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