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PE20060689A1 - Derivados de sulfonamidas como antagonistas de receptores orexina 2 - Google Patents

Derivados de sulfonamidas como antagonistas de receptores orexina 2

Info

Publication number
PE20060689A1
PE20060689A1 PE2005000897A PE2005000897A PE20060689A1 PE 20060689 A1 PE20060689 A1 PE 20060689A1 PE 2005000897 A PE2005000897 A PE 2005000897A PE 2005000897 A PE2005000897 A PE 2005000897A PE 20060689 A1 PE20060689 A1 PE 20060689A1
Authority
PE
Peru
Prior art keywords
alkyl
phenyl
alcoxy
methyl
chloro
Prior art date
Application number
PE2005000897A
Other languages
English (en)
Inventor
Gilles Courtemanche
Pierre Despeyroux
Pierrick Rochard
Gal Claudine Serradeil-Le
Evelyne Fontaine
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34947042&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20060689(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20060689A1 publication Critical patent/PE20060689A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/44—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE Ar1 ES FENILO, HETEROCICLILO SUSTITUIDO O NO POR HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4, ENTRE OTROS; T ES (CH2)n, CH3OH, N-(ALQUILO C1-C4), ENTRE OTROS; n ES 0-2; Ar2 ES FENILO SUSTITUIDO O NO POR HALOGENO, ALQUILO C1-C4, ENTRE OTROS O PIRINIDILO SUSTITUIDO POR ALQUILO C1-C4, ALCOXI C1-C4; Ar3 ES FENILO Y NAFTILO SUSTITUIDO O NO POR HALOGENO, ALQUILO C1-C4, ALCOXI C1-C4, NITRO, ENTRE OTROS; R1 ES CO-CF3 O UN GRUPO DE FORMULA A DONDE n ES 0-3; R7 ES H, ALQUILO C1-C4, F, ALCOXI C1-C4, ENTRE OTROS; R8 ES H, F, ALQUILO C1-C4, ENTRE OTROS; R9 ES H, HIDROXILO, CICLOALQUILO C3-C6, ALCOXI C1-C4, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-{4-CLORO-2-[(2-CLOROFENIL)(HIDROXI)METIL]FENIL}-N-[(3,4-DIMETOXIFENIL)SULFONIL]GLICINATO DE ETILO; N-{4-CLORO-2-[(2-CLOROFENIL)(HIDROXI)METIL]FENIL}-N-[(2-ETIL-2H-TETRAZOL-5-IL)METIL]-3,4-DIMETOXIBENCENSULFONAMIDA; N-{4-CLORO-2-[(3-CLOROFENIL)(HIDROXI)METIL]FENIL}-N-[(3,4-DIMETOXIFENIL)SULFONIL]GLICINATO DE ETILO; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES DE LA OREXINA 2, UTILES EN EL TRATAMIENTO DE OBESIDAD , PERTURBACIONES DEL APETITO O GUSTO, TRASTORNOS DEL HUMOR Y DEL COMPORTAMIENTO, TRASTORNOS DEL APRENDIZAJE Y LA MEMORIA
PE2005000897A 2004-08-03 2005-08-02 Derivados de sulfonamidas como antagonistas de receptores orexina 2 PE20060689A1 (es)

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Application Number Priority Date Filing Date Title
FR0408546A FR2874011B1 (fr) 2004-08-03 2004-08-03 Derives de sulfonamides, leur preparation et leur application en therapeutique

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PE20060689A1 true PE20060689A1 (es) 2006-08-10

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AU2005279088A1 (en) 2006-03-09
ZA200701482B (en) 2008-10-29
MA28752B1 (fr) 2007-07-02
NO20071197L (no) 2007-03-27
EA200700112A1 (ru) 2007-08-31
FR2874011A1 (fr) 2006-02-10
EP1776347A1 (fr) 2007-04-25
WO2006024779A1 (fr) 2006-03-09
FR2874011B1 (fr) 2007-06-15
AR050364A1 (es) 2006-10-18
MX2007001437A (es) 2007-04-19
KR20070053726A (ko) 2007-05-25
BRPI0513068A (pt) 2008-04-22
UY29047A1 (es) 2006-03-31
CN101090892A (zh) 2007-12-19
JP2008509115A (ja) 2008-03-27
EP1776347B1 (fr) 2010-05-26
ATE469131T1 (de) 2010-06-15
US20070185136A1 (en) 2007-08-09
IL181069A0 (en) 2007-07-04
DE602005021501D1 (de) 2010-07-08
TW200609204A (en) 2006-03-16
CA2577220A1 (fr) 2006-03-09
US7396958B2 (en) 2008-07-08

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