PE20040914A1 - Derivados de pirrolopirimidina como inhibidores de tirosina quinasas - Google Patents
Derivados de pirrolopirimidina como inhibidores de tirosina quinasasInfo
- Publication number
- PE20040914A1 PE20040914A1 PE2003001266A PE2003001266A PE20040914A1 PE 20040914 A1 PE20040914 A1 PE 20040914A1 PE 2003001266 A PE2003001266 A PE 2003001266A PE 2003001266 A PE2003001266 A PE 2003001266A PE 20040914 A1 PE20040914 A1 PE 20040914A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- alkyl
- cycloalkyl
- groups
- pyrrolo
- Prior art date
Links
- 150000004944 pyrrolopyrimidines Chemical class 0.000 title abstract 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- AMVHAASGKCIUQB-UHFFFAOYSA-N 1-[3-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)phenyl]-3-(2-chlorophenyl)urea Chemical compound C12=C(N)N=CN=C2N(C(C)C)C=C1C(=O)C(C=1)=CC=CC=1NC(=O)NC1=CC=CC=C1Cl AMVHAASGKCIUQB-UHFFFAOYSA-N 0.000 abstract 1
- NBIMLOJSKMKITL-UHFFFAOYSA-N 1-[3-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)phenyl]-3-(2-fluoro-5-methylphenyl)urea Chemical compound C12=C(N)N=CN=C2N(C(C)C)C=C1C(=O)C(C=1)=CC=CC=1NC(=O)NC1=CC(C)=CC=C1F NBIMLOJSKMKITL-UHFFFAOYSA-N 0.000 abstract 1
- JIJYZDRUGWAJLR-UHFFFAOYSA-N 1-[3-(4-amino-7-propan-2-ylpyrrolo[2,3-d]pyrimidine-5-carbonyl)phenyl]-3-(2-methoxy-5-methylphenyl)urea Chemical compound COC1=CC=C(C)C=C1NC(=O)NC1=CC=CC(C(=O)C=2C3=C(N)N=CN=C3N(C(C)C)C=2)=C1 JIJYZDRUGWAJLR-UHFFFAOYSA-N 0.000 abstract 1
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical class F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229940127361 Receptor Tyrosine Kinase Inhibitors Drugs 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical class 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIRROLOPIRIMIDINA DE FORMULA I DONDE Q ES CO, CR11R12, NR11 o S(O)n; n ES 0 A 2; A ES UN ENLACE, ARILO C6-C10, ANILLO HETEROAROMATICO DE 5-13 MIEMBROS, ENTRE OTROS, TODOS OPCIONALMENTE SUSTITUIDOS CON 1-5 GRUPOS R5; L ES (CH2)p, O, S, S(O), S(O)2, ENTRE OTROS; p ES 0 A 5; R1 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, BICICLOALQUILO SUSTITUIDO, CICLOALQUENILO DE 5-8 MIEMBROS, ENTRE OTROS, TODOS SUSTITUIDOS CON 1-5 GRUPOS R10; R2 ES H, HALO, ALQUILO C1-C6, CICLOALQUILO C3-C8, GRUPO AROMATICO DE 6-10 MIEMBROS, ENTRE OTROS, TODOS SUSTITUIDOS CON 1-5 GRUPOS R5; R3 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, ENTRE OTROS, TODOS OPCIONALMENTE SUSTITUIDOS CON 1-5 GRUPOS R5; R5 ES HALO, CIANO, TRIFLUOROMETOXI, TRIFLUOROMETILO, ENTRE OTROS; R11 Y R12 SON, INDEPENDIENTEMENTE ENTRE SI, H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ALCOXI C1-C6 o R11 Y R12 TOMADOS JUNTOS FORMAN UN ANILLO ALQUILO O HETEROALQUILO DE 3-7 MIEMBROS. SON COMPUESTOS PREFERIDOS: 1-[3-(4-AMINO-7-ISOPROPIL-7H-PIRROLO[2,3-d]PIRIMIDINA-5-CARBONIL)-FENIL]-3-(2-CLORO-FENIL)-UREA; 1-[3-(4-AMINO-7-ISOPROPIL-7H-PIRROLO[2,3-d]PIRIMIDINA-5-CARBONIL)-FENIL]-3-(2-METOXI-5-METIL-FENIL)-UREA; 1-[3-(4-AMINO-7-ISOPROPIL-7H-PIRROLO[2,3-d]PIRIMIDINA-5-CARBONIL)-FENIL]-3-(2-FLUORO-5-METIL-FENIL)-UREA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE TIROSINA QUINASA RECEPTORAS Y SON UTILES COMO INHIBIDORES SELECTIVOS DEL CRECIMIENTO DE CELULAS CANCERIGENAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43456802P | 2002-12-19 | 2002-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040914A1 true PE20040914A1 (es) | 2005-01-08 |
Family
ID=32682064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001266A PE20040914A1 (es) | 2002-12-19 | 2003-12-11 | Derivados de pirrolopirimidina como inhibidores de tirosina quinasas |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US7271262B2 (es) |
| EP (1) | EP1578751B1 (es) |
| JP (1) | JP4057013B2 (es) |
| KR (2) | KR20050084402A (es) |
| CN (1) | CN1726218A (es) |
| AP (1) | AP2005003342A0 (es) |
| AR (1) | AR042509A1 (es) |
| AT (1) | ATE512965T1 (es) |
| AU (1) | AU2003286317A1 (es) |
| BR (1) | BR0317524A (es) |
| CA (1) | CA2510853C (es) |
| EA (1) | EA200500814A1 (es) |
| EC (1) | ECSP055867A (es) |
| ES (1) | ES2364649T3 (es) |
| GT (1) | GT200300289A (es) |
| HN (1) | HN2003000416A (es) |
| HR (1) | HRP20050560A2 (es) |
| IS (1) | IS7872A (es) |
| MA (1) | MA27568A1 (es) |
| MX (1) | MXPA05006793A (es) |
| NL (1) | NL1025068C2 (es) |
| NO (1) | NO20052802L (es) |
| NZ (1) | NZ540456A (es) |
| OA (1) | OA12976A (es) |
| PA (1) | PA8591701A1 (es) |
| PE (1) | PE20040914A1 (es) |
| PL (1) | PL377774A1 (es) |
| RS (1) | RS20050469A (es) |
| TN (1) | TNSN05165A1 (es) |
| TW (1) | TW200423939A (es) |
| UA (1) | UA80171C2 (es) |
| UY (1) | UY28132A1 (es) |
| WO (1) | WO2004056830A1 (es) |
| ZA (1) | ZA200504440B (es) |
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| MY143225A (en) * | 2004-04-02 | 2011-03-31 | Osi Pharm Inc | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
| JP4842929B2 (ja) * | 2004-05-27 | 2011-12-21 | ファイザー・プロダクツ・インク | 癌治療に有用なピロロピリミジン誘導体 |
| MY139689A (en) * | 2004-07-20 | 2009-10-30 | Osi Pharm Inc | Imidazotriazines as protein kinase inhibitors |
| US7625931B2 (en) | 2005-01-14 | 2009-12-01 | Cgi Pharmaceuticals, Inc. | Certain substituted diphenyl ureas, as modulators of kinase activity |
| US20070287719A1 (en) * | 2005-03-11 | 2007-12-13 | Pfizer Inc | Salts, Prodrugs and Formulations of 1-[5-(4-Amino-7-Isopropyl-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carbonyl)-2-Methoxy-Phenyl]-3-(2,4-Dichloro-Phenyl)-Urea |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| US7795248B2 (en) * | 2005-05-18 | 2010-09-14 | Abbott Laboratories, Inc. | Substituted 7,8-dihydro-1H-pyrimido[4,5-B][1,4]diazepin-4-amines are novel kinase inhibitors |
| DE102005037499A1 (de) * | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
| WO2007024754A1 (en) * | 2005-08-22 | 2007-03-01 | Amgen Inc. | Bis-aryl urea compounds for the treatment of protein kinase-mediated diseaes |
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| AU2007323725B2 (en) | 2006-11-22 | 2014-02-20 | Incyte Holdings Corporation | Imidazotriazines and imidazopyrimidines as kinase inhibitors |
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