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MX2009006650A - Pirimidinas substituidas que contienen una porcion heteroarilamida o heteroarilfenilo. - Google Patents

Pirimidinas substituidas que contienen una porcion heteroarilamida o heteroarilfenilo.

Info

Publication number
MX2009006650A
MX2009006650A MX2009006650A MX2009006650A MX2009006650A MX 2009006650 A MX2009006650 A MX 2009006650A MX 2009006650 A MX2009006650 A MX 2009006650A MX 2009006650 A MX2009006650 A MX 2009006650A MX 2009006650 A MX2009006650 A MX 2009006650A
Authority
MX
Mexico
Prior art keywords
heteroarylphenyl
heteroarylamide
moiety
substituted piperidines
group
Prior art date
Application number
MX2009006650A
Other languages
English (en)
Inventor
Richard William Arthur Luke
Marinus Leendert Verdonk
Steven John Woodhead
Hannah Fiona Sore
David Winter Walker
Ian Collins
Zbigniew Stanley Matusiak
Christopher Hamlett
Tatiana Faria Da Fonseca Mchardy
Gregory Richard Carr
Jeffrey James Morris
Kwai Ming Cheung
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0625682A external-priority patent/GB0625682D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of MX2009006650A publication Critical patent/MX2009006650A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona compuestos de la fórmula (I) que tienen compuestos inhibidores de PKA o PKB cinasa de la fórmula (I): GP 1 J T 2 J N 4 R N H (I) o sales, solvatos, tautómeros o N-óxidos de los mismos, en donde (1) GP es un grupo GP1; HET 2a a Q G (HNCO)f 7 (R )x N * (GP1) (2) GP es un grupo GP2: 10 (R)r O 2a a QG (CH2)w N y H N * (GP2), en donde HET es un grupo heterocíclico monocíclico o bicíclico que contiene hasta 4 miembros de anti de átomo heterogéneo; el anillo y es un grupo heteroarilo monocíclico o bicíclico de 5 a 10 miembros de anillo; y JI, J2, R4, R7, RI0, Q2a, Ga, x, w y f son como se define en las reivindicaciones.
MX2009006650A 2006-12-21 2007-12-20 Pirimidinas substituidas que contienen una porcion heteroarilamida o heteroarilfenilo. MX2009006650A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87135506P 2006-12-21 2006-12-21
GB0625682A GB0625682D0 (en) 2006-12-21 2006-12-21 Pharmaceutical compounds
US98263607P 2007-10-25 2007-10-25
US98615007P 2007-11-07 2007-11-07
PCT/GB2007/050777 WO2008075110A1 (en) 2006-12-21 2007-12-20 Substituted piperidines containing a heteroarylamide or heteroarylphenyl moiety

Publications (1)

Publication Number Publication Date
MX2009006650A true MX2009006650A (es) 2009-08-20

Family

ID=39301245

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006650A MX2009006650A (es) 2006-12-21 2007-12-20 Pirimidinas substituidas que contienen una porcion heteroarilamida o heteroarilfenilo.

Country Status (15)

Country Link
US (1) US20100120798A1 (es)
EP (1) EP2125820A1 (es)
JP (1) JP2010513453A (es)
KR (1) KR20090104030A (es)
AR (1) AR064415A1 (es)
AU (1) AU2007335969A1 (es)
BR (1) BRPI0721124A2 (es)
CA (1) CA2672841A1 (es)
EC (1) ECSP099446A (es)
MX (1) MX2009006650A (es)
NO (1) NO20092341L (es)
PE (1) PE20081680A1 (es)
TW (1) TW200833694A (es)
UY (1) UY30823A1 (es)
WO (1) WO2008075110A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
EP2043655A2 (en) 2006-04-25 2009-04-08 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
JP4705695B2 (ja) 2007-10-11 2011-06-22 アストラゼネカ アクチボラグ プロテインキナーゼｂ阻害剤としてのピロロ［２，３−ｄ］ピリミジン誘導体
EA019488B1 (ru) * 2008-04-21 2014-04-30 Лексикон Фармасьютикалз, Инк. Ингибиторы limk2 и способы их применения
US9045485B2 (en) 2010-12-16 2015-06-02 Convergence Pharmaceuticals Limited ASK 1 inhibiting pyrrolopyrimidine derivatives
JP6080837B2 (ja) 2011-04-01 2017-02-15 アストラゼネカ アクチボラグ 療法的治療
CN103814030A (zh) * 2011-09-22 2014-05-21 辉瑞大药厂 吡咯并嘧啶及嘌呤衍生物
KR102035361B1 (ko) 2011-11-30 2019-11-08 아스트라제네카 아베 암의 병용 치료
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
CN104119342A (zh) * 2013-04-25 2014-10-29 苏州科捷生物医药有限公司 一种制备高纯度4-氯-5-甲基-7H-吡咯[2,3-d]嘧啶的方法
PT3980417T (pt) 2019-06-10 2023-12-28 Lupin Ltd Inibidores de prmt5

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5213229B2 (ja) * 2004-04-23 2013-06-19 エグゼリクシス， インコーポレイテッド キナーゼ調節因子および使用方法
MY179032A (en) * 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
US7994172B2 (en) * 2004-12-28 2011-08-09 Exelixis, Inc. [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases
EP2013206A1 (en) * 2006-04-25 2009-01-14 Astex Therapeutics Limited Pharmaceutical compounds
EP2029592A1 (en) * 2006-04-25 2009-03-04 Astex Therapeutics Limited Pharmaceutical compounds
WO2007125310A2 (en) * 2006-04-25 2007-11-08 Astex Therapeutics Limited Pharmaceutical combinations of pk inhibitors and other active agents

Also Published As

Publication number Publication date
WO2008075110A1 (en) 2008-06-26
PE20081680A1 (es) 2008-12-18
AU2007335969A1 (en) 2008-06-26
CA2672841A1 (en) 2008-06-26
BRPI0721124A2 (pt) 2014-03-04
NO20092341L (no) 2009-07-21
ECSP099446A (es) 2009-09-29
KR20090104030A (ko) 2009-10-05
JP2010513453A (ja) 2010-04-30
EP2125820A1 (en) 2009-12-02
TW200833694A (en) 2008-08-16
AR064415A1 (es) 2009-04-01
UY30823A1 (es) 2008-07-31
US20100120798A1 (en) 2010-05-13

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