PE20040451A1 - Activadores cicloalquil sustituidos y cicloalquil oxigenados de glucoquinasa - Google Patents
Activadores cicloalquil sustituidos y cicloalquil oxigenados de glucoquinasaInfo
- Publication number
- PE20040451A1 PE20040451A1 PE2003000409A PE2003000409A PE20040451A1 PE 20040451 A1 PE20040451 A1 PE 20040451A1 PE 2003000409 A PE2003000409 A PE 2003000409A PE 2003000409 A PE2003000409 A PE 2003000409A PE 20040451 A1 PE20040451 A1 PE 20040451A1
- Authority
- PE
- Peru
- Prior art keywords
- substituted
- chain
- cycloalkyl
- oxo
- nitro
- Prior art date
Links
- 102000030595 Glucokinase Human genes 0.000 title abstract 2
- 108010021582 Glucokinase Proteins 0.000 title abstract 2
- 239000012190 activator Substances 0.000 title abstract 2
- -1 AMINO GROUP Chemical group 0.000 abstract 4
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940080818 propionamide Drugs 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/50—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 Y R2 SON INDEPENDIENTEMENTE H, HALO, HIDROXIAMINO, CIANO, NITRO, ALQUILO INFERIOR, -OR5, PERFLUOROALQUILO ENTRE OTROS; R3 ES UNA CADENA DE ALQUILO NO RAMIFICADO DE 4-5 CARBONOS O HETEROALQUILO NO RAMIFICADO DE 3-4 CARBONOS MAS UN O o S DONDE LA CADENA EN COMBINACION CON UN C AL QUE ESTA UNIDO FORMA UN ANILLO DE 5-6 MIEMBROS Y SI LA CADENA NO TIENE HETEROATOMOS UN C PUEDE ESTAR SUSTITUIDO POR -OH, OXO, HIDROXIIMINO, ENTRE OTROS, SI TIENE UN HETEROATOMO DE O o S LA CADENA NO ESTA SUSTITUIDA, O EL S ESTE SUSTITUIDO POR UN OXO; R4 ES -CONHR6 O UN HETEROAROMATICO DE 5-6 MIEMBROS NO SUSTITUIDO O MONO-SUSTITUIDO UNIDO CON UN C AL GRUPO AMINO, ESTE ANILLO PUEDE TENER DE 1 A 3 HETEROATOMOS DE S, O o N, DICHO ANILLO PUEDE ESTAR SUSTITUIDO POR ALQUILO INFERIOR, HALO, NITRO, CIANO, NITRO, PERFLUOROALQUILO, AMIDOOXIMA, -(CH2)n-OR7, -(CH2)n-CO-OR7, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-[2-(3,4-DICLORO-FENIL)-3-(TETRAHIDRO-FURAN-2-IL)-PROPIONIL]-3-METIL-UREA.1-[2-(3,4-DICLORO-FENIL)-3-(2-HIDROXI-CICLOPENTIL)-PROPIONIL]-3-METIL-UREA, 2(R)-(3-CLORO-4-METANOSULFONIL-FENIL)-3-((R)-3-OXO-CICLOPENTIL)-N-PIRAZIN-2-IL-PROPIONAMIDA.TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON ACTIVADORES DE LA GLUCOQUINASA Y SON UTILES EN EL TRATAMIENTO DE LA DIABETES TIPO II
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37616102P | 2002-04-26 | 2002-04-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040451A1 true PE20040451A1 (es) | 2004-07-21 |
Family
ID=29420328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000409A PE20040451A1 (es) | 2002-04-26 | 2003-04-24 | Activadores cicloalquil sustituidos y cicloalquil oxigenados de glucoquinasa |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US7105671B2 (es) |
| EP (1) | EP1501815B1 (es) |
| JP (1) | JP4091600B2 (es) |
| KR (1) | KR100669587B1 (es) |
| CN (1) | CN1329386C (es) |
| AR (1) | AR039665A1 (es) |
| AT (1) | ATE346056T1 (es) |
| AU (1) | AU2003232204B8 (es) |
| BR (1) | BR0309546A (es) |
| CA (1) | CA2482346C (es) |
| DE (1) | DE60309856T2 (es) |
| DK (1) | DK1501815T3 (es) |
| EA (1) | EA011297B1 (es) |
| EC (1) | ECSP045382A (es) |
| ES (1) | ES2276097T3 (es) |
| GT (1) | GT200300096A (es) |
| HR (1) | HRP20040953A2 (es) |
| IL (1) | IL164780A (es) |
| MA (1) | MA27113A1 (es) |
| MX (1) | MXPA04010605A (es) |
| MY (1) | MY135222A (es) |
| NO (1) | NO20044534L (es) |
| NZ (1) | NZ535706A (es) |
| PA (1) | PA8572301A1 (es) |
| PE (1) | PE20040451A1 (es) |
| PL (1) | PL373701A1 (es) |
| PT (1) | PT1501815E (es) |
| RS (1) | RS93604A (es) |
| TN (1) | TNSN04211A1 (es) |
| TW (1) | TWI281917B (es) |
| UA (1) | UA80427C2 (es) |
| UY (1) | UY27787A1 (es) |
| WO (1) | WO2003095438A1 (es) |
| ZA (1) | ZA200407986B (es) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04115996U (ja) * | 1991-03-28 | 1992-10-15 | 東洋運搬機株式会社 | ボートリフタ |
| SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| CA2498089A1 (en) * | 2002-10-03 | 2004-06-17 | Novartis Ag | Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes |
| GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
| PL378117A1 (pl) * | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
| AU2005214132B9 (en) | 2004-02-18 | 2009-06-25 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
| CN101098876A (zh) | 2004-04-02 | 2008-01-02 | 诺瓦提斯公司 | 噻唑并吡啶衍生物、包含它们的药物形式以及治疗葡糖激酶介导的病症的方法 |
| JP4700684B2 (ja) | 2004-04-02 | 2011-06-15 | ノバルティス アーゲー | ２型糖尿病の処置に有用なグルコキナーゼアクティベーターとしてのスルホンアミド−チアゾロピリジン誘導体 |
| JP2007533722A (ja) * | 2004-04-21 | 2007-11-22 | プロシディオン・リミテッド | トリ（シクロ）置換アミド化合物 |
| TW200600086A (en) | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
| CA2576407A1 (en) * | 2004-08-12 | 2006-02-16 | Prosidion Limited | Substituted phenylacetamides and their use as glucokinase activators |
| GB0418046D0 (en) * | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Eantioselective process |
| GB0418058D0 (en) * | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Fluorination process |
| NZ575512A (en) | 2005-07-09 | 2009-11-27 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| AR057661A1 (es) | 2005-07-11 | 2007-12-12 | Tanabe Seiyaku Co | Un derivado de oxima y sus preparaciones |
| EP1921074A1 (en) | 2005-08-31 | 2008-05-14 | Astellas Pharma Inc. | Thiazole derivative |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| NZ566877A (en) | 2005-09-29 | 2010-05-28 | Sanofi Aventis | Phenyl-1,2,4-oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| GT200600428A (es) | 2005-09-30 | 2007-05-21 | Compuestos organicos | |
| GT200600429A (es) | 2005-09-30 | 2007-04-30 | Compuestos organicos | |
| WO2007048717A1 (en) | 2005-10-24 | 2007-05-03 | F. Hoffmann-La Roche Ag | Preparation of cyclic, ketalized ketones by favorskii rearrangement and the use thereof for the preparation of glucokinase activator 70 |
| US20080293741A1 (en) * | 2005-11-03 | 2008-11-27 | Matthew Colin Thor Fyfe | Tricyclo Substituted Amides as Glucokinase Modulators |
| WO2007104034A2 (en) | 2006-03-08 | 2007-09-13 | Takeda San Diego, Inc. | Glucokinase activators |
| WO2007115967A1 (en) * | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Crystalline isopropanol solvate of glucokinase activator |
| WO2007115968A2 (en) * | 2006-04-12 | 2007-10-18 | F. Hoffmann-La Roche Ag | Process for the preparation of a glucokinase activator |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| WO2007143434A2 (en) | 2006-05-31 | 2007-12-13 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents |
| MY154798A (en) | 2006-06-27 | 2015-07-31 | Takeda Pharmaceutical | Fused cyclic compounds |
| US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
| US7888504B2 (en) | 2006-07-06 | 2011-02-15 | Bristol-Myers Squibb Company | Glucokinase activators and methods of using same |
| AU2007278261A1 (en) | 2006-07-24 | 2008-01-31 | F. Hoffmann-La Roche Ag | Pyrazoles as glucokinase activators |
| TW200819457A (en) | 2006-08-30 | 2008-05-01 | Actelion Pharmaceuticals Ltd | Spiro antibiotic derivatives |
| TW200825060A (en) | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
| US7902248B2 (en) * | 2006-12-14 | 2011-03-08 | Hoffmann-La Roche Inc. | Oxime glucokinase activators |
| WO2008079787A2 (en) | 2006-12-20 | 2008-07-03 | Takeda San Diego, Inc. | Glucokinase activators |
| WO2008074694A1 (en) * | 2006-12-20 | 2008-06-26 | F. Hoffmann-La Roche Ag | Crystallization of glucokinase activators |
| TW200831081A (en) * | 2006-12-25 | 2008-08-01 | Kyorin Seiyaku Kk | Glucokinase activator |
| WO2008080822A1 (en) * | 2006-12-29 | 2008-07-10 | F. Hoffmann-La Roche Ag | Epimerization methodologies for recovering stereo isomers in high yield and purity |
| WO2008080824A1 (en) * | 2006-12-29 | 2008-07-10 | F. Hoffmann-La Roche Ag | Aromatic sulfonated ketals |
| EP2105435A4 (en) | 2007-01-10 | 2011-06-15 | Mitsubishi Tanabe Pharma Corp | Hydrazone derivative |
| CN101687800B (zh) * | 2007-03-07 | 2012-03-21 | 杏林制药株式会社 | 葡糖激酶活化物质 |
| WO2008116107A2 (en) | 2007-03-21 | 2008-09-25 | Takeda San Diego, Inc. | Piperazine derivatives as glucokinase activators |
| AU2008310519B2 (en) * | 2007-10-08 | 2013-05-02 | Advinus Therapeutics Private Limited | Acetamide derivatives as glucokinase activators, their process and medicinal applications |
| RU2010134411A (ru) | 2008-01-18 | 2012-02-27 | Астеллас Фарма Инк. (Jp) | Фенилацетамидное производное |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| US8258134B2 (en) * | 2008-04-16 | 2012-09-04 | Hoffmann-La Roche Inc. | Pyridazinone glucokinase activators |
| RU2565070C2 (ru) * | 2008-04-28 | 2015-10-20 | Киорин Фармасьютикал Ко., Лтд. | Производное циклопентилакриламида |
| US20110021570A1 (en) | 2009-07-23 | 2011-01-27 | Nancy-Ellen Haynes | Pyridone glucokinase activators |
| US8222416B2 (en) | 2009-12-14 | 2012-07-17 | Hoffmann-La Roche Inc. | Azaindole glucokinase activators |
| WO2011123572A1 (en) | 2010-03-31 | 2011-10-06 | The Scripps Research Institute | Reprogramming cells |
| US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
| EP2878339A1 (en) | 2013-12-02 | 2015-06-03 | Siena Biotech S.p.A. | SIP3 antagonists |
| CN108495850B (zh) | 2016-08-31 | 2021-11-26 | 江苏恒瑞医药股份有限公司 | 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用 |
| GB201714777D0 (en) | 2017-09-14 | 2017-11-01 | Univ London Queen Mary | Agent |
| US11076596B2 (en) | 2017-09-18 | 2021-08-03 | Basf Se | Substituted trifluoromethyloxadiazoles for combating phytopathogenic fungi |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE249241C (es) | 1910-05-01 | 1912-07-13 | ||
| US3431301A (en) * | 1966-03-24 | 1969-03-04 | Hoffmann La Roche | Process for producing methylhydrazine derivatives |
| US3776917A (en) * | 1972-06-05 | 1973-12-04 | Schering Corp | 2-amino-6-phenalkyl-aminopyridines and derivatives thereof |
| ES419319A1 (es) | 1973-10-04 | 1976-03-01 | Gallardo Antonio Sa | Un procedimiento para la obtencion de derivados de acidos 3-benzoilfenilalcanoicos. |
| GB8909574D0 (en) * | 1989-04-26 | 1989-06-14 | Ici Plc | Chemical process |
| US5169951A (en) * | 1990-04-23 | 1992-12-08 | Ciba-Geigy Corporation | Process for preparing nematicidal compositions |
| DE69322118T2 (de) | 1992-04-17 | 1999-05-20 | Hodogaya Chemical Co., Ltd., Tokio/Tokyo | Amino-Thiazolderivate und ihre Anwendung als Fungizide |
| US5556859A (en) * | 1994-12-22 | 1996-09-17 | Dowelanco | N-(4-pyrimidinyl)amide pesticides |
| GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| HRP20010688B1 (en) * | 1999-03-29 | 2008-10-31 | F. Hoffmann - La Roche Ag | Glucokinase activators |
| MXPA03000365A (es) * | 2000-07-20 | 2003-05-27 | Hoffmann La Roche | Bencenacetamida substituida con alfa-acilo y alfa-heteroatomo como activadores de la glucocinasa. |
-
2003
- 2003-04-14 WO PCT/EP2003/003844 patent/WO2003095438A1/en not_active Ceased
- 2003-04-14 DE DE60309856T patent/DE60309856T2/de not_active Expired - Lifetime
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