[go: up one dir, main page]

PE20030236A1 - Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados - Google Patents

Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados

Info

Publication number
PE20030236A1
PE20030236A1 PE2002000612A PE2002000612A PE20030236A1 PE 20030236 A1 PE20030236 A1 PE 20030236A1 PE 2002000612 A PE2002000612 A PE 2002000612A PE 2002000612 A PE2002000612 A PE 2002000612A PE 20030236 A1 PE20030236 A1 PE 20030236A1
Authority
PE
Peru
Prior art keywords
derivatives
pharmaceutical preparations
preparations containing
aril
benzimidazole
Prior art date
Application number
PE2002000612A
Other languages
English (en)
Inventor
Thorsten Blume
Wolfgang Halfbrodt
Ursula Monning
Herbert Schneider
Joachim Kuhnke
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20030236A1 publication Critical patent/PE20030236A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE BENCIMIDAZOL DE FORMULA I DONDE R1 ES UN GRUPO ARILO, GRUPO HETEROARILO DE 5-6 MIEMBROS CON UNO O DOS HETEROATOMOS SELECCIONADOS DE N, S, O; EL GRUPO ARILO PUEDE ESTAR SUSTITUIDO CON F, Cl, Br, C(NH)NH2, C(NH)NHR4, ENTRE OTROS; Z ES NH, NR2', O, S, SO, SO2; R2 Y R2' SON PERFLURALQUILO C1-C4, ALQUILO C1-C6, (C0-3-ALCANODIIL-CICLOALQUILO C3-C7), ENTRE OTROS; R3 ES H, F, Cl, Br, OH, OR4, OCOR4, OCONHR4, COR4, CH, COOH, ENTRE OTROS; A ES ALCANODIILO C1-C10, ALQUENDIILO C2-C10, ALQUINDIILO C2-C10, ENTRE OTROS; B ES UN RADICAL SELECCIONADO DE COOH, COOR5, CONH2, ENTRE OTROS; Y ES O, NH, NR4, NSO2R4, ENTRE OTROS; R4 Y R4' SON CF3, C2F5, ALQUILO C1-C4, ALQUENILO C2-C4, ALQUINILO C2-C3, ENTRE OTROS; R5 Y R5' SON ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS. SON COMPUESTOS PREFERIDOS ESTER METILICO DEL ACIDO 6-[[1-FENIL-2-PROPILMERCAPTO-1H-BENCIMIDAZOL-6-IL]OXI]HEXANOICO, ESTER METILICO DEL ACIDO 6-[[1-FENIL-2-PROPANSULFONIL-1H-BENCIMIDAZOL-6-IL]OXI]HEXANOICO, ENTRE OTROS. LOS DERIVADOS DE BENCIMIDAZOL SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES ALERGICAS, INFECCIOSAS, AUTOINMUNES
PE2002000612A 2001-07-09 2002-07-09 Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados PE20030236A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10135050A DE10135050A1 (de) 2001-07-09 2001-07-09 1-Ary1-2-N-, S- oder O-substituierte Benzimidazolderivate, deren Verwendung zur Herstellung von Arzneimitteln sowie diese Derivate enthaltende pharmazeutische Präparate

Publications (1)

Publication Number Publication Date
PE20030236A1 true PE20030236A1 (es) 2003-04-10

Family

ID=7692286

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000612A PE20030236A1 (es) 2001-07-09 2002-07-09 Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados

Country Status (10)

Country Link
EP (1) EP1404656B9 (es)
JP (1) JP4351042B2 (es)
AT (1) ATE295838T1 (es)
DE (2) DE10135050A1 (es)
DK (1) DK1404656T3 (es)
ES (1) ES2242866T3 (es)
PE (1) PE20030236A1 (es)
PT (1) PT1404656E (es)
UY (1) UY27372A1 (es)
WO (1) WO2003006438A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10207843A1 (de) * 2002-02-15 2003-09-04 Schering Ag Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen
CA2494942A1 (en) 2002-08-08 2004-02-19 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzimidazole compounds
WO2004035549A1 (en) 2002-10-17 2004-04-29 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
JPWO2006038738A1 (ja) * 2004-10-08 2008-05-15 武田薬品工業株式会社 受容体機能調節剤
ATE488235T1 (de) 2005-01-11 2010-12-15 Neurosearch As Neue 2-amino-benzimidazolderivate und ihre verwendung als modulatoren calciumaktivierter kaliumkanäle mit geringer leitfähigkeit
CN103435552A (zh) * 2013-06-28 2013-12-11 浙江工业大学 一种1,2-二取代苯并咪唑类化合物的制备方法
IL316875A (en) 2018-10-05 2025-01-01 Annapurna Bio Inc Compounds and compositions for treating conditions associated with APJ receptor activity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
US4520196A (en) * 1983-08-18 1985-05-28 American Home Products Corporation α-Mercaptophenylacetic acid derivatives of imidazole-containing compounds and analogues thereof
EP0251536A1 (en) * 1986-06-24 1988-01-07 FISONS plc Benzimidazoles, their production, formulation and use as gastric acid secretion inhibitors
JPH06759B2 (ja) * 1989-09-22 1994-01-05 ファイザー製薬株式会社 新規なベンゾイミダゾール化合物
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
DK0520200T3 (da) * 1991-06-24 1998-09-23 Neurosearch As Imadazol-forbindelser, deres fremstilling og anvendelse
DE4129603A1 (de) * 1991-09-06 1993-03-11 Thomae Gmbh Dr K Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DK154092D0 (da) * 1992-12-23 1992-12-23 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
DE4330959A1 (de) * 1993-09-09 1995-03-16 Schering Ag Neue Benzimidazolderivate, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US5552426A (en) * 1994-04-29 1996-09-03 Eli Lilly And Company Methods for treating a physiological disorder associated with β-amyloid peptide
GB9518552D0 (en) * 1995-09-11 1995-11-08 Fujisawa Pharmaceutical Co New heterocyclic compounds
DE19816915A1 (de) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Neue Peptide, Verfahren zu ihrer Herstellung und diese Peptide enthaltende pharmazeutische Zusammensetzungen
JP2000026430A (ja) * 1998-07-02 2000-01-25 Taisho Pharmaceut Co Ltd ２、５、６−置換ベンズイミダゾール化合物誘導体
DE19900355A1 (de) * 1999-01-07 2000-07-13 Merck Patent Gmbh Benzimidazolderivate
EP1165518A2 (en) * 1999-04-02 2002-01-02 Neurogen Corporation Benzimidazole and imidazolopyridine derivatives, their preparation and their use as selective modulators of bradykinin b2 (= bk-2) receptors
CA2383546A1 (en) * 1999-06-30 2001-01-04 William H. Parsons Src kinase inhibitor compounds
CA2363274A1 (en) * 1999-12-27 2001-07-05 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs for hepatitis c
MEP13308A (en) * 2000-01-14 2010-10-10 Bayer Schering Pharma Ag 1,2-diaryl benzimidazoles for treating illnesses associated with a microglia activation

Also Published As

Publication number Publication date
PT1404656E (pt) 2005-09-30
WO2003006438A1 (de) 2003-01-23
DK1404656T3 (da) 2005-09-12
ES2242866T3 (es) 2005-11-16
EP1404656A1 (de) 2004-04-07
DE10135050A1 (de) 2003-02-06
EP1404656B9 (de) 2005-10-19
DE50203154D1 (de) 2005-06-23
EP1404656B1 (de) 2005-05-18
UY27372A1 (es) 2003-01-31
JP4351042B2 (ja) 2009-10-28
JP2004536123A (ja) 2004-12-02
ATE295838T1 (de) 2005-06-15

Similar Documents

Publication Publication Date Title
AU2002218167A1 (en) N-phenyl-2-pyrimidine-amine derivatives
SE9904505D0 (sv) Novel compounds
SE0001899D0 (sv) New compounds
NO20024005D0 (no) Pteridinforbindelser for behandling av psoriasis
GB0112348D0 (en) Compounds
NO20042596L (no) Inbibitorer av 11-beta-hydroksy steroid dehydrogenase type 1
MY139302A (en) Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
EA200300248A1 (ru) Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
MY139303A (en) Novel aromatic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof
DE60224172D1 (de) Formanilid-derivative als beta2-adrenorezeptor-agonisten
ATE442142T1 (de) Fredericamycin-derivate als arzneimittel zur tumorbehandlung
TW200510325A (en) 2-acylamino-4-phenylthiazole derivatives, preparation thereof and therapeutic application thereof
ATE316083T1 (de) Adamantanderivate
EA200500377A1 (ru) Пиразольные производные как ингибиторы трансформирующего фактора роста (tgf)
TNSN04203A1 (en) Benzoxazinone-derived compounds, their preparation and use as medicaments
ATE386725T1 (de) Heterocyclylverbindungen
DE60001586D1 (de) Diphenyl-piperidin derivate
BR0107628A (pt) l,2-diarilbenzimidazóis para tratamento de doenças que estão associadas a uma ativação microglial
DK1251846T3 (da) C4-Carbonattaxaner
SE9903894D0 (sv) Novel compounds
ATE360428T1 (de) Analgetisches arzneimittel
PE20030236A1 (es) Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados
IT1307786B1 (it) Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali.
MY139613A (en) Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders
NO20020914D0 (no) Alkoksy-substituerte benzimidazolforbindelser, preparater inneholdende slike samt anvendelser derav

Legal Events

Date Code Title Description
FA Abandonment or withdrawal