PE20030948A1 - Proceso para la preparacion de una suspension esteril de particulas de dipropionato de beclometasona para administracion por inhalacion - Google Patents
Proceso para la preparacion de una suspension esteril de particulas de dipropionato de beclometasona para administracion por inhalacionInfo
- Publication number
- PE20030948A1 PE20030948A1 PE2003000389A PE2003000389A PE20030948A1 PE 20030948 A1 PE20030948 A1 PE 20030948A1 PE 2003000389 A PE2003000389 A PE 2003000389A PE 2003000389 A PE2003000389 A PE 2003000389A PE 20030948 A1 PE20030948 A1 PE 20030948A1
- Authority
- PE
- Peru
- Prior art keywords
- turbine
- beclometasone dipropionate
- istiling
- corticosteroid
- suspension
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000725 suspension Substances 0.000 title abstract 3
- KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 title abstract 2
- 229950000210 beclometasone dipropionate Drugs 0.000 title abstract 2
- 239000002245 particle Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 3
- RLQJEEJISHYWON-UHFFFAOYSA-N flonicamid Chemical compound FC(F)(F)C1=CC=NC=C1C(=O)NCC#N RLQJEEJISHYWON-UHFFFAOYSA-N 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003246 corticosteroid Substances 0.000 abstract 2
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 239000006096 absorbing agent Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000002663 nebulization Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000035939 shock Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Abstract
QUE COMPRENDE: 1)AGREGAR UNO O MAS INGREDIENTES ACTIVOS, TAL COMO UN CORTICOSTEROIDE, BAJO LA FORMA DE UN POLVO ESTERIL MICRONIZADO, A UNA SOLUCION ACUOSA QUE CONSTITUYE EL VEHICULO, LA CUAL CONTIENE ADITIVOS O EXCIPIENTES SELECCIONADOS ENTRE AGENTES HUMECTANTES, ESTABILIZADORES, ISOTONICOS Y/O AMORTIGUADORES, EN UN TURBO EMULSIFICADOR EQUIPADO CON UNA TURBINA DE ALTO PODER Y CONECTADO A UNA TOLVA DE CARGA, INTRODUCIENDO LOS INGREDIENTES ACTIVOS A TRAVES DE LA TURBINA DESPUES DE APLICAR EL VACIO; 2)HOMOGENEIZAR EL INGREDIENTE ACTIVO EN LA SUSPENSION, AUN AL VACIO, USANDO EL SISTEMA DE TURBINA, A UNA VELOCIDAD ENTRE 750 rpm Y 4000 rpm DURANTE 10 min A 60 min; Y, 3)DISTRIBUIR LA SUSPENSION OBTENIDA DE ESTE MODO EN RECIPIENTES ADECUADOS DE DOSIS INDIVIDUALES . DONDE, EL PROCESO SE REALIZA BAJO CONDICIONES ESTERILES, AGREGANDO UN CORTICOSTEROIDE, TAL COMO DIPROPIONATO DE BECLOMETASONA, ESTERILIZADO POR IRRADIACION O CALENTAMIENTO. SE REFIERE TAMBIEN A FORMULACIONES FARMACEUTICAS QUE SE UTILIZAN PARA NEBULIZACION, EN EL TRATAMIENTO DE ENFERMEDADES PULMONARES, QUE CONSTAN DE DOSIS UNITARIAS QUE CONTIENEN SUSPENSIONES ACUOSAS OBTENIDAS EN EL PROCESO ANTES DESCRITO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000808A ITMI20020808A1 (it) | 2002-04-17 | 2002-04-17 | Procedimento per la preparazione di una sospensione sterile di particelle di beclometasone dipropionato da somministrare per inalazione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030948A1 true PE20030948A1 (es) | 2004-01-19 |
Family
ID=11449718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003000389A PE20030948A1 (es) | 2002-04-17 | 2003-04-16 | Proceso para la preparacion de una suspension esteril de particulas de dipropionato de beclometasona para administracion por inhalacion |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7541021B2 (es) |
| EP (1) | EP1494647B1 (es) |
| CN (1) | CN1292733C (es) |
| AR (1) | AR039317A1 (es) |
| AT (1) | ATE338539T1 (es) |
| AU (1) | AU2003227627A1 (es) |
| BR (1) | BRPI0304821B8 (es) |
| CA (1) | CA2481520C (es) |
| CY (1) | CY1105800T1 (es) |
| DE (1) | DE60308164T2 (es) |
| DK (1) | DK1494647T3 (es) |
| EA (1) | EA007629B1 (es) |
| ES (1) | ES2272987T3 (es) |
| HK (1) | HK1079986B (es) |
| HR (1) | HRP20040964A2 (es) |
| IT (1) | ITMI20020808A1 (es) |
| MA (1) | MA27194A1 (es) |
| MX (1) | MXPA04010117A (es) |
| PE (1) | PE20030948A1 (es) |
| PL (1) | PL207863B1 (es) |
| PT (1) | PT1494647E (es) |
| SI (1) | SI1494647T1 (es) |
| UA (1) | UA79453C2 (es) |
| WO (1) | WO2003086347A1 (es) |
| ZA (1) | ZA200408319B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004052374A1 (en) * | 2002-12-12 | 2004-06-24 | Altana Pharma Ag | Combination medicament |
| PL1670482T5 (pl) * | 2003-09-16 | 2022-10-03 | Covis Pharma Gmbh | Zastosowanie cyklezonidu w leczeniu chorób układu oddechowego |
| CA2543242C (en) * | 2003-10-23 | 2015-04-14 | Otsuka Pharmaceutical Co., Ltd. | Controlled release sterile freeze-dried aripiprazole formulation and injectable formulation thereof |
| PE20050941A1 (es) * | 2003-12-16 | 2005-11-08 | Nycomed Gmbh | Suspensiones acuosas de ciclesonida para nebulizacion |
| US20070020299A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| US20070020298A1 (en) * | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether gamma-cyclodextrin and corticosteroid |
| EP1740188A1 (en) * | 2004-04-20 | 2007-01-10 | Altana Pharma AG | Use of ciclesonide for the treatment of respiratory diseases in a smoking patient |
| GB0425266D0 (en) | 2004-11-16 | 2004-12-15 | Norton Healthcare Ltd | Pharmaceutical manufacturing process |
| EP1683514B1 (en) | 2005-01-20 | 2012-05-23 | Eratech S.r.l. | Process for the preparation of concentrated suspensions of drugs and kit thereof |
| US20070148100A1 (en) * | 2005-09-15 | 2007-06-28 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
| US20070099883A1 (en) * | 2005-10-07 | 2007-05-03 | Cheryl Lynn Calis | Anhydrous mometasone furoate formulation |
| JP2009526619A (ja) * | 2006-02-15 | 2009-07-23 | ティカ レーケメデル アーベー | 質量減量を伴うコルチコステロイドの滅菌 |
| PT2170348T (pt) * | 2007-06-22 | 2016-11-02 | Dompé Farm S P A | Comprimidos efervescentes para utilização por via inalatória |
| US12370352B2 (en) | 2007-06-28 | 2025-07-29 | Cydex Pharmaceuticals, Inc. | Nasal and ophthalmic delivery of aqueous corticosteroid solutions |
| MX2010001311A (es) * | 2007-07-31 | 2010-04-21 | Otsuka Pharma Co Ltd | Metodo para producir una suspensi?n de aripiprazol y formulacion liofilizada. |
| CN102657659A (zh) * | 2010-11-23 | 2012-09-12 | 天津金耀集团有限公司 | 皮肤用含有辅料的丙酸氟替卡松与含有辅料的水的透皮吸收药物 |
| CN102475708A (zh) * | 2010-11-23 | 2012-05-30 | 天津金耀集团有限公司 | 丙酸氟替卡松和含辅料的水构成的治疗皮肤病的分离式水混悬剂药物 |
| HUE030016T2 (en) | 2011-05-03 | 2017-04-28 | Chiesi Farm Spa | An improved suspension beclomethasone dipropionate formulation for inhalation administration |
| CN103505412A (zh) * | 2012-06-26 | 2014-01-15 | 上海臣邦医药科技有限公司 | 一种吸入用丙酸氟替卡松混悬液的制备方法 |
| WO2022098321A1 (en) * | 2020-11-09 | 2022-05-12 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Process for the preparation of sterilised suspensions for the administration by inhalation |
| WO2022231533A1 (en) * | 2021-04-29 | 2022-11-03 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Process for the preparation of sterilized suspensions for the inhalation by nebulization |
| WO2022231531A1 (en) * | 2021-04-29 | 2022-11-03 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Process for the preparation of sterilized suspensions for the inhalation by nebulization |
| WO2023022672A2 (en) * | 2021-08-18 | 2023-02-23 | Arven Ilac Sanayi Ve Ticaret Anonim Sirketi | Process for the preparation of homogeneous suspensions for the inhalation by nebulization |
| WO2024180569A1 (en) * | 2023-03-01 | 2024-09-06 | Ajaykumar Balraj Kanduri | A synergistic aqueous nebulization suspension for management of infectious respiratory disorders and process of preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1303692B1 (it) * | 1998-11-03 | 2001-02-23 | Chiesi Farma Spa | Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione. |
| ITMI20022674A1 (it) * | 2002-12-18 | 2004-06-19 | Chiesi Farma Spa | Procedimento per la preparazione di formulazioni sterili a base di principi attivi farmaceutici cristallini micronizzati da somministrare come sospensioni acquose per inalazione. |
-
2002
- 2002-04-17 IT IT2002MI000808A patent/ITMI20020808A1/it unknown
-
2003
- 2003-04-15 HR HR20040964A patent/HRP20040964A2/hr not_active Application Discontinuation
- 2003-04-15 EA EA200401209A patent/EA007629B1/ru unknown
- 2003-04-15 BR BRPI0304821A patent/BRPI0304821B8/pt not_active IP Right Cessation
- 2003-04-15 PT PT03725033T patent/PT1494647E/pt unknown
- 2003-04-15 AT AT03725033T patent/ATE338539T1/de active
- 2003-04-15 MX MXPA04010117A patent/MXPA04010117A/es active IP Right Grant
- 2003-04-15 SI SI200330532T patent/SI1494647T1/sl unknown
- 2003-04-15 CN CNB038111608A patent/CN1292733C/zh not_active Expired - Lifetime
- 2003-04-15 EP EP03725033A patent/EP1494647B1/en not_active Expired - Lifetime
- 2003-04-15 US US10/510,232 patent/US7541021B2/en not_active Expired - Fee Related
- 2003-04-15 WO PCT/EP2003/003916 patent/WO2003086347A1/en not_active Ceased
- 2003-04-15 ES ES03725033T patent/ES2272987T3/es not_active Expired - Lifetime
- 2003-04-15 DE DE60308164T patent/DE60308164T2/de not_active Expired - Lifetime
- 2003-04-15 CA CA2481520A patent/CA2481520C/en not_active Expired - Fee Related
- 2003-04-15 HK HK06100045.9A patent/HK1079986B/zh not_active IP Right Cessation
- 2003-04-15 AU AU2003227627A patent/AU2003227627A1/en not_active Abandoned
- 2003-04-15 DK DK03725033T patent/DK1494647T3/da active
- 2003-04-15 PL PL373331A patent/PL207863B1/pl unknown
- 2003-04-15 UA UA20041008327A patent/UA79453C2/uk unknown
- 2003-04-16 AR ARP030101350A patent/AR039317A1/es unknown
- 2003-04-16 PE PE2003000389A patent/PE20030948A1/es not_active Application Discontinuation
-
2004
- 2004-10-08 MA MA27897A patent/MA27194A1/fr unknown
- 2004-10-14 ZA ZA200408319A patent/ZA200408319B/xx unknown
-
2006
- 2006-11-21 CY CY20061101689T patent/CY1105800T1/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |