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PE20030549A1 - Derivados de 1,6-naftiridina y su uso para el tratamiento de la diabetes y transtornos relacionados - Google Patents

Derivados de 1,6-naftiridina y su uso para el tratamiento de la diabetes y transtornos relacionados

Info

Publication number
PE20030549A1
PE20030549A1 PE2002000943A PE2002000943A PE20030549A1 PE 20030549 A1 PE20030549 A1 PE 20030549A1 PE 2002000943 A PE2002000943 A PE 2002000943A PE 2002000943 A PE2002000943 A PE 2002000943A PE 20030549 A1 PE20030549 A1 PE 20030549A1
Authority
PE
Peru
Prior art keywords
alkyl
alkinyl
alkenyl
naphthyridin
heteroaryl
Prior art date
Application number
PE2002000943A
Other languages
English (en)
Inventor
William H Bullock
Yamin Wang
Libing Chen
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of PE20030549A1 publication Critical patent/PE20030549A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Transplantation (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE 1,6-NAFTIRIDINA DE FORMULA I DONDE R1' ES ALQUILO, ALQUENILO, ALQUINILO, AR9, ARILO, HETEROARILO; A ES ALQUILO, ALQUENILO, ALQUINILO, HALOALQUILO; R2' ES NR15R16, SO(0-2)R17, OR17; R15 ES H, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, CICLOALQUENILO, HETEROCICLOALQUILO, ENTRE OTROS; R16 ES ALQUILO, ALQUENILO, ALQUINILO, ARILO, HETEROARILO; R17 ES ALQUILO, ALQUENILO, ALQUINILO, HALOALQUILO, AR9; R3' ES ARILO, HETEROARILO, CICLOALQUILO, HETEROCICLOALQUILO, ENTRE OTROS; R4' ES O, S, OR21; R21 ES H, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO; R5', R7', R8' SON CICLOALQUILO, CICLOALQUENILO, ARILO, HETEROARILO. SON COMPUESTOS PREFERIDOS 2-ANILINO-5-METIL-1-FENIL-1,8-NAFTIRIDIN-4(1H)-ONA; 5-METIL-7-MORFOLIN-4-IL-1-FENIL-2-FENILAMINO-1H-[1,8]-NAFTIRIDIN-4-ONA; 5-METIL-1-FENIL-2,7-BIS-FENILAMINO-1H-[1,8]NAFTIRIDIN-4-ONA; 2-ANILINO-1,7-DIFENIL-5-(TRIFLUOROMETIL)-1,8-NAFTIRIDIN-4(1H)-ONA; ENTRE OTROS. TAMBIEN SE REFIERE AL USO CON UN AGONISTA PPAR, INSULINO SENSIBILIZANTE, SULFONILUREA, SECRETAGOGO DE INSULINA, UN PRODUCTO QUE REDUCE LA PRODUCCION DE GLUCOSA HEPATICA, INHIBIDOR DE O-GLUCOSIDASA. LOS COMPUESTOS PUEDEN SER UTILES PARA EL TRATAMIENTO DE DIABETES, INTOLERANCIA A LA GLUCOSA EN AYUNAS
PE2002000943A 2001-09-26 2002-09-25 Derivados de 1,6-naftiridina y su uso para el tratamiento de la diabetes y transtornos relacionados PE20030549A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32451101P 2001-09-26 2001-09-26

Publications (1)

Publication Number Publication Date
PE20030549A1 true PE20030549A1 (es) 2003-08-18

Family

ID=23263913

Family Applications (2)

Application Number Title Priority Date Filing Date
PE2002000943A PE20030549A1 (es) 2001-09-26 2002-09-25 Derivados de 1,6-naftiridina y su uso para el tratamiento de la diabetes y transtornos relacionados
PE2002000944A PE20030601A1 (es) 2001-09-26 2002-09-25 Derivados de 1,8-naftiridina y su uso para el tratamiento de la diabetes y transtornos relacionados

Family Applications After (1)

Application Number Title Priority Date Filing Date
PE2002000944A PE20030601A1 (es) 2001-09-26 2002-09-25 Derivados de 1,8-naftiridina y su uso para el tratamiento de la diabetes y transtornos relacionados

Country Status (24)

Country Link
US (5) US6677352B1 (es)
EP (2) EP1432710A1 (es)
JP (2) JP2005504807A (es)
KR (2) KR20040041178A (es)
CN (2) CN1578780A (es)
AR (2) AR037503A1 (es)
BR (2) BR0212829A (es)
CA (2) CA2461132A1 (es)
CO (2) CO5560542A2 (es)
EC (2) ECSP045081A (es)
GT (2) GT200200191A (es)
HN (1) HN2002000275A (es)
HR (2) HRP20040309A2 (es)
HU (2) HUP0402310A2 (es)
IL (2) IL160708A0 (es)
MA (2) MA27079A1 (es)
MX (2) MXPA04002136A (es)
NO (2) NO20041567L (es)
PE (2) PE20030549A1 (es)
PL (2) PL369531A1 (es)
RU (2) RU2004112787A (es)
UY (2) UY27456A1 (es)
WO (2) WO2003027112A1 (es)
ZA (2) ZA200403063B (es)

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