PE20030493A1 - Hepta-,octa-,y nonapeptidos con actividad antiangiogenica - Google Patents
Hepta-,octa-,y nonapeptidos con actividad antiangiogenicaInfo
- Publication number
- PE20030493A1 PE20030493A1 PE2002001059A PE2002001059A PE20030493A1 PE 20030493 A1 PE20030493 A1 PE 20030493A1 PE 2002001059 A PE2002001059 A PE 2002001059A PE 2002001059 A PE2002001059 A PE 2002001059A PE 20030493 A1 PE20030493 A1 PE 20030493A1
- Authority
- PE
- Peru
- Prior art keywords
- ile
- nva
- thr
- arg
- alanh2
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Gynecology & Obstetrics (AREA)
Abstract
SE REFIERE A PEPTIDOS DE FORMULA Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10; (SEQ ID NO1); Xaa1 ES H, R-(CH2)n-CO; n ES 0-8; R ES ALCOXI, ALQUILO, AMINO, ARILO, CARBOXILO, ENTRE OTROS; Xaa2 ES ALANILO, (1S,3R)-1-AMINOCICLOHEPTANO-3-CARBONILO, ASPARRAGINILO, ENTRE OTROS; Xaa3 ES ALANILO, (1R,4S)-1-AMINOCICLOPENT-2-EN-4-CARBONILO, ARGINILO, ENTRE OTROS; Xaa4 ES D-ALANILO, D-ALOISOLEUCINO, D-ALILGLICILO, D-4-CLOROFENILALANILO, ENTRE OTROS; Xaa5 ES ALOTREONILO, ASPARTILO, GLUTAMILO, GLICILO, HISTIDILO, ENTRE OTROS; Xaa6 ES ALANILO, ALOTREONILO, ARGINILO, GLUTAMINILO, GLICILO, HOMOSERILO, LEUCILO, ENTRE OTROS; Xaa7 ES ALANILO, ALOISOLEUCILO, ASPARTILO, CITRULILO, ISOLEUCILO, NORVALILO, ENTRE OTROS; Xaa8 ES ARGINILO, CITRULILO, GLUTAMINILO, HISTIDILO, HOMOARGINILO, LISILO, ORNITILO, ENTRE OTROS; Xaa9 ES N-METIL-D-ALANILO, 2-AMINOBUTIRILO, HOMOPROLILO, HIDROXIPROLILO, LEUCILO, ENTRE OTROS; Xaa10 ES D-ALANILAMIDA, AZAGLICICLAMIDA, GLICILAMIDA, NH(CH2)n-CHR1R2, NHR3; n ES 0-8; R1 ES H, ALQUILO, CICLOALQUENILO, CICLOALQUILO; R2 ES H, ALCOXI, ALQUILO, ARILO, CICLOALQUENILO. SON COMPUESTOS PREFERIDOS N-AC-(4CH3)PHE-GLN-D-ILE-THR-NVA-ILE-ARG-PRO-D-ALANH2; N-AC-GLN-VAL-D-ILE-THR-NVA-ILE-ARG-PRO-D-ALANH2; N-AC-GLY-ASN-D-ILE-THR-NVA-ILE-ARG-PRO-D-ALANH2; N-AC-GLY-VAL-D-ILE-THR-NVA-ILE-ARG-PRONHCH2CH3; ENTRE OTROS. LOS COMPUESTOS INHIBEN LA ANGIOGENESIS Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE CANCER, TUMORES SOLIDOS PRIMARIOS, METASTASTASICOS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/000,681 US20030125259A1 (en) | 2001-10-31 | 2001-10-31 | Octa- and nonapeptides having antiangiogenic activity |
| US10/263,812 US20030096758A1 (en) | 2001-10-31 | 2002-10-04 | HEPTA-, OCTA- and nonapeptides having antiangiogenic activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030493A1 true PE20030493A1 (es) | 2003-06-10 |
Family
ID=21692581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001059A PE20030493A1 (es) | 2001-10-31 | 2002-10-28 | Hepta-,octa-,y nonapeptidos con actividad antiangiogenica |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20030125259A1 (es) |
| EP (1) | EP2177530B1 (es) |
| KR (1) | KR20040054759A (es) |
| AR (1) | AR037165A1 (es) |
| AT (1) | ATE513846T1 (es) |
| CY (1) | CY1112574T1 (es) |
| DK (1) | DK2177530T3 (es) |
| ES (1) | ES2367166T3 (es) |
| PE (1) | PE20030493A1 (es) |
| PT (1) | PT2177530E (es) |
| SA (1) | SA02230488B1 (es) |
| SI (1) | SI2177530T1 (es) |
| UY (1) | UY27524A1 (es) |
| ZA (1) | ZA200403242B (es) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932545A (en) * | 1997-03-17 | 1999-08-03 | Abbott Laboratories | Antiangiogenic drug to treat cancer, arthritis and retinopathy |
| DE19724793A1 (de) * | 1997-06-06 | 1998-12-10 | Schering Ag | D-mutierte Peptide mit VEGF-Rezeptor blockierenden Eigenschaften |
| JP2002513804A (ja) * | 1998-05-05 | 2002-05-14 | アドヘレックス テクノロジーズ インコーポレイテッド | 非古典的カドヘリン媒介機能を調節するための化合物および方法 |
| SK286554B6 (sk) | 1998-05-22 | 2008-12-05 | Abbott Laboratories | Peptidické antiangiogénne liečivá, farmaceutický prostriedok s ich obsahom a ich použitie |
| DE60025648T2 (de) | 1999-11-22 | 2006-09-14 | Abbott Laboratories, Abbott Park | Peptide mit antiangiogener aktivität |
| CO5261544A1 (es) | 1999-11-22 | 2003-03-31 | Abbott Lab | Peptidos n-alquilados que tienen actividad antiangiogenica |
-
2001
- 2001-10-31 US US10/000,681 patent/US20030125259A1/en not_active Abandoned
-
2002
- 2002-10-04 US US10/263,812 patent/US20030096758A1/en not_active Abandoned
- 2002-10-28 PE PE2002001059A patent/PE20030493A1/es not_active Application Discontinuation
- 2002-10-30 PT PT10153271T patent/PT2177530E/pt unknown
- 2002-10-30 EP EP10153271A patent/EP2177530B1/en not_active Expired - Lifetime
- 2002-10-30 SI SI200230952T patent/SI2177530T1/sl unknown
- 2002-10-30 KR KR10-2004-7006643A patent/KR20040054759A/ko not_active Ceased
- 2002-10-30 AT AT10153271T patent/ATE513846T1/de active
- 2002-10-30 DK DK10153271.1T patent/DK2177530T3/da active
- 2002-10-30 UY UY27524A patent/UY27524A1/es not_active Application Discontinuation
- 2002-10-30 AR ARP020104135A patent/AR037165A1/es unknown
- 2002-10-30 ES ES10153271T patent/ES2367166T3/es not_active Expired - Lifetime
- 2002-12-28 SA SA02230488A patent/SA02230488B1/ar unknown
-
2004
- 2004-04-29 ZA ZA200403242A patent/ZA200403242B/xx unknown
-
2011
- 2011-08-31 CY CY20111100841T patent/CY1112574T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20030125259A1 (en) | 2003-07-03 |
| ES2367166T3 (es) | 2011-10-28 |
| SA02230488B1 (ar) | 2008-09-17 |
| ZA200403242B (en) | 2005-08-15 |
| AR037165A1 (es) | 2004-10-27 |
| PT2177530E (pt) | 2011-09-02 |
| CY1112574T1 (el) | 2016-02-10 |
| UY27524A1 (es) | 2003-05-30 |
| EP2177530B1 (en) | 2011-06-22 |
| SI2177530T1 (sl) | 2011-09-30 |
| KR20040054759A (ko) | 2004-06-25 |
| EP2177530A1 (en) | 2010-04-21 |
| US20030096758A1 (en) | 2003-05-22 |
| DK2177530T3 (da) | 2011-10-10 |
| ATE513846T1 (de) | 2011-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |