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PE20021096A1 - Derivados de 4-amino-5-fenil-7-ciclobutil-pirrolo[2,3-d]pirimidina como inhibidores de la tirosina-cinasa igf-ir - Google Patents

Derivados de 4-amino-5-fenil-7-ciclobutil-pirrolo[2,3-d]pirimidina como inhibidores de la tirosina-cinasa igf-ir

Info

Publication number
PE20021096A1
PE20021096A1 PE2002000402A PE2002000402A PE20021096A1 PE 20021096 A1 PE20021096 A1 PE 20021096A1 PE 2002000402 A PE2002000402 A PE 2002000402A PE 2002000402 A PE2002000402 A PE 2002000402A PE 20021096 A1 PE20021096 A1 PE 20021096A1
Authority
PE
Peru
Prior art keywords
amino
phenyl
alkyl
pirrolo
cyclobutyl
Prior art date
Application number
PE2002000402A
Other languages
English (en)
Inventor
Hans-Georg Capraro
Pascal Furet
Carlos Garcia-Echeverria
Paul William Manley
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0111764A external-priority patent/GB0111764D0/en
Priority claimed from GB0204752A external-priority patent/GB0204752D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20021096A1 publication Critical patent/PE20021096A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DE 4-AMINO-5-FENIL-7-CICLOBUTIL-PIRROLO(2,3-D)PIRIMIDINA DE FORMULA I DONDE n ES 0-4; R1 ES H, ALQUILO, HALOGENO; R2 ES ALQUILO CON OH, AMINO CON UN RADICAL HETEROCICLICO, UN RADICAL R5-(C=Y)-Z- DONDE R5 ES ALQUILO, AMINO, ENTRE OTROS; Z NO ESTA PRESENTE O ES ALQUILO, AMINOALQUILO, ENTRE OTROS; R3 ES ALQUILO CON OH, AMINO, HALOGENO, ENTRE OTROS; R4 ES UN RADICAL R7-CR8(R9)- DONDE R7 ES CICLOBUTILO, CICLOPENTILO, CICLOHEXILO, FENILO, FURILO, PIRROLILO, TIENILO, ENTRE OTROS; R7 ES ALQUILO, HALOGENO; R8 Y R9 SON H, ALQUILO, HALOGENO; X ES -O-, -NH-, -S-. SON COMPUESTOS PREFERIDOS CIS/TRANS-7-(3-AMINOMETIL-CICLOBUTIL)-5-(3-BENCILOXI-FENIL)-7H-PIRROLO[2,3-d]PIRIMIDIN-4-ILAMINA, DIMETILAMIDA DEL ACIDO CIS-3-(4-AMINO-5-(3-BENCILOXI-FENIL)-PIRROLO[2,3-d]PIRIMIDIN-7-IL]-CICLOBUTANOCARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE LA TIROSINA CINASA Y SON UTILES PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS Y TUMORALES
PE2002000402A 2001-05-14 2002-05-14 Derivados de 4-amino-5-fenil-7-ciclobutil-pirrolo[2,3-d]pirimidina como inhibidores de la tirosina-cinasa igf-ir PE20021096A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0111764A GB0111764D0 (en) 2001-05-14 2001-05-14 Organic compounds
GB0204752A GB0204752D0 (en) 2002-02-28 2002-02-28 Organic compounds

Publications (1)

Publication Number Publication Date
PE20021096A1 true PE20021096A1 (es) 2003-03-03

Family

ID=26246078

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000402A PE20021096A1 (es) 2001-05-14 2002-05-14 Derivados de 4-amino-5-fenil-7-ciclobutil-pirrolo[2,3-d]pirimidina como inhibidores de la tirosina-cinasa igf-ir

Country Status (26)

Country Link
US (1) US7326699B2 (es)
EP (1) EP1390369B1 (es)
JP (1) JP4099399B2 (es)
KR (1) KR100583704B1 (es)
CN (1) CN1264844C (es)
AR (1) AR035885A1 (es)
AT (1) ATE309245T1 (es)
AU (1) AU2002312905B2 (es)
BR (1) BR0209658A (es)
CA (1) CA2446435C (es)
CO (1) CO5540346A2 (es)
CZ (1) CZ20033067A3 (es)
DE (1) DE60207241T2 (es)
ES (1) ES2252465T3 (es)
HU (1) HUP0304082A3 (es)
IL (1) IL158697A0 (es)
MX (1) MXPA03010402A (es)
MY (1) MY124853A (es)
NO (1) NO20034929L (es)
NZ (1) NZ529256A (es)
PE (1) PE20021096A1 (es)
PL (1) PL363866A1 (es)
RU (1) RU2305682C2 (es)
SK (1) SK14022003A3 (es)
TW (1) TWI238824B (es)
WO (1) WO2002092599A1 (es)

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