MXPA05008584A - Compuestos heterociclicos utiles como activadores de nurr-1. - Google Patents
Compuestos heterociclicos utiles como activadores de nurr-1.Info
- Publication number
- MXPA05008584A MXPA05008584A MXPA05008584A MXPA05008584A MXPA05008584A MX PA05008584 A MXPA05008584 A MX PA05008584A MX PA05008584 A MXPA05008584 A MX PA05008584A MX PA05008584 A MXPA05008584 A MX PA05008584A MX PA05008584 A MXPA05008584 A MX PA05008584A
- Authority
- MX
- Mexico
- Prior art keywords
- alkoxy
- alkyl
- hydroxy
- nurr
- activators
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invencion se refiere a compuestos de la formula I: en donde: R1 es hidroxi, alcoxi de C1-4, amino, alquilamino de C1-4, dialquilamino de C1-4, benciloxi o alcanoilo de C2-7, R2 es alquilo de C1-4, alcoxi de C1-4, alcoxi de C1-4-alcoxi de C1-4, CF3, halogeno, alquilamino de C1-4, dialquilamino de C1-4, dialquilamino de C1-4-alcoxi de C1-4 o N-alcoxi de C1-4-alquilo de C1-4-N-alquilamino de C1-4, N-alquilpiperazinilo de C1-4, morfolinilo, pirrolidinilalcoxi de C1-4, en donde los radicales alquilo de C1-4, en R2 ademas estan opcionalmente substituidos por alquilo de C1-4, halogeno, ciano, amino, alcoxi o alquiltio, X es N u O, Y es N, O u CH, Z es N o CH, y W es N o CH, siempre que (a) R1 no sea hidroxi o alcoxi de C1-4 cuando R2 sea CF3, X sea O, Y sea CH, Z sea N y W sea CH, (b) R1 no sea hidroxi o alcoxi de C1-4 cuando R2 es CF3 o cloro, X es N, Y es O, Z es CH y W es CH, (c) R1 no sea hidroxi cuando R2 sea CF3, X sea O, Y sea N, Z sea CH y W sea CH y (d) X e Y simultaneamente no sean O, sus sales; su preparacion, su uso y composiciones farmaceuticas que lo contienen (ver formula I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0303503.7A GB0303503D0 (en) | 2003-02-14 | 2003-02-14 | Organic compounds |
| PCT/EP2004/001372 WO2004072050A1 (en) | 2003-02-14 | 2004-02-13 | Heterocyclic compounds useful as nurr-1 activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MXPA05008584A true MXPA05008584A (es) | 2005-11-04 |
Family
ID=9953078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MXPA05008584A MXPA05008584A (es) | 2003-02-14 | 2004-02-13 | Compuestos heterociclicos utiles como activadores de nurr-1. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7432293B2 (es) |
| EP (1) | EP1597243A1 (es) |
| JP (1) | JP2006517564A (es) |
| CN (2) | CN101665469A (es) |
| AR (1) | AR043168A1 (es) |
| AU (1) | AU2004212151B2 (es) |
| BR (1) | BRPI0407479A (es) |
| CA (1) | CA2515847A1 (es) |
| GB (1) | GB0303503D0 (es) |
| MX (1) | MXPA05008584A (es) |
| PE (1) | PE20050193A1 (es) |
| PL (1) | PL376754A1 (es) |
| TW (1) | TW200502225A (es) |
| WO (1) | WO2004072050A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6992096B2 (en) | 2003-04-11 | 2006-01-31 | Ptc Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| WO2006044456A1 (en) * | 2004-10-13 | 2006-04-27 | Ptc Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
| PT1874306E (pt) | 2005-04-08 | 2012-10-11 | Ptc Therapeutics Inc | Composições de um 1,2,4-oxadiazole oralmente activo para terapia de supressão de mutações sem sentido (ou nonsense) |
| AU2006239418A1 (en) | 2005-04-26 | 2006-11-02 | Neurosearch A/S | Novel oxadiazole derivatives and their medical use |
| SG170819A1 (en) | 2006-03-30 | 2011-05-30 | Ptc Therapeutics Inc | Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith |
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| FR2903105A1 (fr) | 2006-07-03 | 2008-01-04 | Sanofi Aventis Sa | Derives de 2-benzoyl-imidazopyridines, leur preparation et leur application en therapeutique |
| FR2903107B1 (fr) | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| CN101535284B (zh) | 2006-09-08 | 2014-12-10 | Ptc医疗公司 | 制备1,2,4-噁二唑苯甲酸的方法 |
| FR2906250B1 (fr) * | 2006-09-22 | 2008-10-31 | Sanofi Aventis Sa | Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique |
| DK2076501T3 (da) | 2006-09-25 | 2016-02-29 | Ptc Therapeutics Inc | Krystallinske former af 3-[5-(2-fluorphenyl)-[1,2,4]oxadiazol-3-yl]-benzoesyre |
| WO2008130370A1 (en) | 2006-09-25 | 2008-10-30 | Ptc Therapeutics, Inc. | Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression |
| EP2073805B1 (en) * | 2006-10-12 | 2015-03-04 | PTC Therapeutics, Inc. | Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy |
| EP2182809B1 (en) * | 2007-08-27 | 2018-01-17 | Dart Neuroscience (Cayman) Ltd | Therapeutic isoxazole compounds |
| DK2307381T3 (da) | 2008-06-09 | 2021-03-15 | Univ Muenchen Ludwig Maximilians | Nye lægemidler til inhibering af aggregering af proteiner involveret i sygdomme forbundet med proteinaggregering og/eller neurodegenerative sygdomme |
| CN102076670B (zh) * | 2008-06-24 | 2013-05-22 | Irm责任有限公司 | 调节g蛋白偶联受体的化合物和方法 |
| FR2933609B1 (fr) | 2008-07-10 | 2010-08-27 | Fournier Lab Sa | Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson. |
| WO2011009484A1 (en) * | 2009-07-22 | 2011-01-27 | Novartis Ag | Arylpyrazoles and arylisoxazoles and their use as pkd modulators |
| FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
| FR2955110A1 (fr) * | 2010-01-08 | 2011-07-15 | Fournier Lab Sa | Nouveaux derives de type pyrrolopyridine benzoique |
| DK2628733T3 (en) * | 2010-10-14 | 2015-03-30 | Daiichi Sankyo Co Ltd | Acylbenzenderivat |
| KR20160078974A (ko) * | 2013-11-05 | 2016-07-05 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 절지동물 방제용 신규 화합물 |
| US9873677B2 (en) | 2014-03-06 | 2018-01-23 | Ptc Therapeutics, Inc. | Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid |
| MX2018005361A (es) | 2015-10-30 | 2018-06-07 | Ptc Therapeutics Inc | Metodos para tratar epilepsia. |
| AU2018265584B2 (en) | 2017-05-12 | 2023-09-28 | Ludwig-Maximilians-Universität München | Phenyl-heterocycle-phenyl derivatives for use in the treatment or prevention of melanoma |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04295470A (ja) * | 1991-03-22 | 1992-10-20 | Wakamoto Pharmaceut Co Ltd | モノアミンオキシダーゼ−ｂ酵素阻害活性を有する１，２，４−オキサジアゾール誘導体及びその製造法 |
| AU6526896A (en) * | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
| DE19620041A1 (de) * | 1996-05-17 | 1998-01-29 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| IT1300055B1 (it) | 1998-04-17 | 2000-04-05 | Boehringer Ingelheim Italia | Eterocicli con anello a 5 termini difenil-sostituiti loro procedimento di preparazione e loro impiego come farmici |
| US6545009B1 (en) * | 1998-07-01 | 2003-04-08 | Takeda Chemical Industries, Ltd. | Retinoid-related receptor function regulating agent |
| JP2000080086A (ja) * | 1998-07-01 | 2000-03-21 | Takeda Chem Ind Ltd | レチノイド関連受容体機能調節剤 |
| DK1070708T3 (da) * | 1999-07-21 | 2004-05-10 | Hoffmann La Roche | Triazolderivater |
| CZ2002599A3 (cs) * | 1999-08-19 | 2002-06-12 | Nps Pharmaceuticals Inc. | Heteropolycyklické sloučeniny a jejich pouľití jako antagonistů metabotropního receptoru glutamátu |
| PL369598A1 (en) * | 2001-02-21 | 2005-05-02 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| US7223791B2 (en) * | 2001-06-26 | 2007-05-29 | Takeda Pharmaceutical Company Limited | Function regulator for retinoid relative receptor |
-
2003
- 2003-02-14 GB GBGB0303503.7A patent/GB0303503D0/en not_active Ceased
-
2004
- 2004-02-12 AR ARP040100440A patent/AR043168A1/es unknown
- 2004-02-12 PE PE2004000155A patent/PE20050193A1/es not_active Application Discontinuation
- 2004-02-13 BR BR0407479-3A patent/BRPI0407479A/pt not_active IP Right Cessation
- 2004-02-13 MX MXPA05008584A patent/MXPA05008584A/es active IP Right Grant
- 2004-02-13 TW TW093103501A patent/TW200502225A/zh unknown
- 2004-02-13 JP JP2006501839A patent/JP2006517564A/ja active Pending
- 2004-02-13 AU AU2004212151A patent/AU2004212151B2/en not_active Ceased
- 2004-02-13 CN CN200910004889A patent/CN101665469A/zh active Pending
- 2004-02-13 EP EP04710812A patent/EP1597243A1/en not_active Withdrawn
- 2004-02-13 CA CA002515847A patent/CA2515847A1/en not_active Abandoned
- 2004-02-13 PL PL376754A patent/PL376754A1/pl not_active Application Discontinuation
- 2004-02-13 CN CNB2004800038107A patent/CN100475795C/zh not_active Expired - Fee Related
- 2004-02-13 WO PCT/EP2004/001372 patent/WO2004072050A1/en not_active Ceased
- 2004-02-13 US US10/545,245 patent/US7432293B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1747942A (zh) | 2006-03-15 |
| JP2006517564A (ja) | 2006-07-27 |
| PL376754A1 (pl) | 2006-01-09 |
| CN100475795C (zh) | 2009-04-08 |
| GB0303503D0 (en) | 2003-03-19 |
| TW200502225A (en) | 2005-01-16 |
| WO2004072050A1 (en) | 2004-08-26 |
| BRPI0407479A (pt) | 2006-02-07 |
| US7432293B2 (en) | 2008-10-07 |
| AU2004212151B2 (en) | 2008-09-04 |
| AU2004212151A1 (en) | 2004-08-26 |
| CN101665469A (zh) | 2010-03-10 |
| US20060089365A1 (en) | 2006-04-27 |
| AR043168A1 (es) | 2005-07-20 |
| PE20050193A1 (es) | 2005-04-11 |
| CA2515847A1 (en) | 2004-08-26 |
| EP1597243A1 (en) | 2005-11-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |