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PE20020338A1 - DERIVADOS DEL 3-INDOLIL-4-FENIL-1H-PIRROL-2,5-DIONA QUE INHIBEN LA GLUCOGENO SINTASA QUINASA-3ß (GSK-3ß) - Google Patents

DERIVADOS DEL 3-INDOLIL-4-FENIL-1H-PIRROL-2,5-DIONA QUE INHIBEN LA GLUCOGENO SINTASA QUINASA-3ß (GSK-3ß)

Info

Publication number
PE20020338A1
PE20020338A1 PE2001000742A PE2001000742A PE20020338A1 PE 20020338 A1 PE20020338 A1 PE 20020338A1 PE 2001000742 A PE2001000742 A PE 2001000742A PE 2001000742 A PE2001000742 A PE 2001000742A PE 20020338 A1 PE20020338 A1 PE 20020338A1
Authority
PE
Peru
Prior art keywords
diona
pyrrol
alkyl
gsk
indolyl
Prior art date
Application number
PE2001000742A
Other languages
English (en)
Inventor
Leyi Gong
Andrew Grupe
Gary Allen Peltz
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20020338A1 publication Critical patent/PE20020338A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DEL 3-INDOLIL-4-FENIL-1H-PIRROL-2,5-DIONA DE FORMULA I DONDE R1 Y R2 SON H, ALQUILO, HALOGENO, HALOALQUILO, TIOALQUILO, HIDROXI, ALCOXI, CIANO, ENTRE OTROS; R3 ES H, ALQUILO, CICLOALQUILO, HETEROALQUILO, COR7 DONDE R7 ES H, ALQUILO, ENTRE OTROS; R4 Y R5 SON H, ALQUILO, HALOGENO, HALOALQUILO, TIOALQUILO, HIDROXI, ENTRE OTROS; R6 ES HETEROALQUILO, HETEROCICLICO, HETEROCICLIL ALQUILO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO PARA LA PREPARACION. SON COMPUESTOS PREFERIDOS 3-(1-METILINDOLIL)-4-[3-(2-HIDROXIETILAMINOFENIL)-1H-PIRROL-2,5-DIONA, 3-(1-METILINDOLIL)-4-[4-(2-HIDROXIETILAMINOFENIL)-1H-PIRROL-2,5-DIONA. LOS COMPUESTOS DESCRITOS SON INHIBIDORES DE LA GLUCOGENO CINTAZA QUINASA--3ß(GSK--3ß) Y SON UTILES PARA EL TRATAMIENTO DE ALZHEIMER, ISQUEMIA, DANO CEREBRAL, ENFERMEDAD BIPOLAR
PE2001000742A 2000-07-27 2001-07-23 DERIVADOS DEL 3-INDOLIL-4-FENIL-1H-PIRROL-2,5-DIONA QUE INHIBEN LA GLUCOGENO SINTASA QUINASA-3ß (GSK-3ß) PE20020338A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22105800P 2000-07-27 2000-07-27

Publications (1)

Publication Number Publication Date
PE20020338A1 true PE20020338A1 (es) 2002-04-23

Family

ID=22826151

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000742A PE20020338A1 (es) 2000-07-27 2001-07-23 DERIVADOS DEL 3-INDOLIL-4-FENIL-1H-PIRROL-2,5-DIONA QUE INHIBEN LA GLUCOGENO SINTASA QUINASA-3ß (GSK-3ß)

Country Status (31)

Country Link
US (2) US6479490B2 (es)
EP (1) EP1307447B1 (es)
JP (1) JP3984157B2 (es)
KR (1) KR20030017655A (es)
CN (1) CN1185229C (es)
AR (1) AR033989A1 (es)
AT (1) ATE284885T1 (es)
AU (1) AU2001293702A1 (es)
BR (1) BR0112965A (es)
CA (1) CA2417277A1 (es)
CZ (1) CZ2003555A3 (es)
DE (1) DE60107857T2 (es)
EC (1) ECSP034452A (es)
ES (1) ES2233691T3 (es)
GT (1) GT200100151A (es)
HR (1) HRP20030030A2 (es)
HU (1) HUP0301431A2 (es)
IL (1) IL153851A0 (es)
JO (1) JO2293B1 (es)
MA (1) MA26936A1 (es)
MX (1) MXPA03000695A (es)
NO (1) NO20030328D0 (es)
NZ (1) NZ523462A (es)
PA (1) PA8523001A1 (es)
PE (1) PE20020338A1 (es)
PL (1) PL366701A1 (es)
RU (1) RU2003104796A (es)
UY (1) UY26857A1 (es)
WO (1) WO2002010158A2 (es)
YU (1) YU4403A (es)
ZA (1) ZA200300216B (es)

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EP1885454A2 (en) 2005-05-04 2008-02-13 DeveloGen Aktiengesellschaft Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders
CA2620333A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
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JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
EP2125683B1 (en) 2006-12-19 2013-10-23 The Board of Trustees of the University of Illinois 3-benzofuranyl-4-indolyl-maleimides as potent gsk-3 inhibitors for neurodegenerative disorders
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Also Published As

Publication number Publication date
PL366701A1 (en) 2005-02-07
CN1185229C (zh) 2005-01-19
AU2001293702A1 (en) 2002-02-13
JP3984157B2 (ja) 2007-10-03
HRP20030030A2 (en) 2005-02-28
US20020052397A1 (en) 2002-05-02
EP1307447A2 (en) 2003-05-07
AR033989A1 (es) 2004-01-21
ES2233691T3 (es) 2005-06-16
PA8523001A1 (es) 2002-10-24
HK1058670A1 (en) 2004-05-28
NO20030328L (no) 2003-01-22
MA26936A1 (fr) 2004-12-20
BR0112965A (pt) 2003-07-08
CA2417277A1 (en) 2002-02-07
US20020188018A1 (en) 2002-12-12
JO2293B1 (en) 2005-09-12
DE60107857T2 (de) 2005-12-08
MXPA03000695A (es) 2003-06-04
YU4403A (sh) 2006-05-25
GT200100151A (es) 2002-05-23
CZ2003555A3 (en) 2004-03-17
ATE284885T1 (de) 2005-01-15
WO2002010158A3 (en) 2002-05-16
ECSP034452A (es) 2003-03-10
NZ523462A (en) 2004-09-24
RU2003104796A (ru) 2004-08-20
KR20030017655A (ko) 2003-03-03
JP2004505078A (ja) 2004-02-19
EP1307447B1 (en) 2004-12-15
IL153851A0 (en) 2003-07-31
DE60107857D1 (de) 2005-01-20
CN1444581A (zh) 2003-09-24
HUP0301431A2 (hu) 2003-08-28
WO2002010158A2 (en) 2002-02-07
UY26857A1 (es) 2002-01-31
ZA200300216B (en) 2004-04-08
NO20030328D0 (no) 2003-01-22
US6479490B2 (en) 2002-11-12

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