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GB9828640D0 - Novel method and compounds - Google Patents

Novel method and compounds

Info

Publication number
GB9828640D0
GB9828640D0 GBGB9828640.4A GB9828640A GB9828640D0 GB 9828640 D0 GB9828640 D0 GB 9828640D0 GB 9828640 A GB9828640 A GB 9828640A GB 9828640 D0 GB9828640 D0 GB 9828640D0
Authority
GB
United Kingdom
Prior art keywords
compounds
novel method
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB9828640.4A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Priority to GBGB9828640.4A priority Critical patent/GB9828640D0/en
Publication of GB9828640D0 publication Critical patent/GB9828640D0/en
Priority to EP99962419A priority patent/EP1140070A1/en
Priority to PCT/GB1999/004374 priority patent/WO2000038675A1/en
Priority to AU18777/00A priority patent/AU1877700A/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GBGB9828640.4A 1998-12-23 1998-12-23 Novel method and compounds Ceased GB9828640D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GBGB9828640.4A GB9828640D0 (en) 1998-12-23 1998-12-23 Novel method and compounds
EP99962419A EP1140070A1 (en) 1998-12-23 1999-12-22 Treatment of conditions with a need for the inhibition of gsk-3
PCT/GB1999/004374 WO2000038675A1 (en) 1998-12-23 1999-12-22 Treatment of conditions with a need for the inhibition of gsk-3
AU18777/00A AU1877700A (en) 1998-12-23 1999-12-22 Treatment of conditions with a need for the inhibition of gsk-3

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9828640.4A GB9828640D0 (en) 1998-12-23 1998-12-23 Novel method and compounds

Publications (1)

Publication Number Publication Date
GB9828640D0 true GB9828640D0 (en) 1999-02-17

Family

ID=10845024

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9828640.4A Ceased GB9828640D0 (en) 1998-12-23 1998-12-23 Novel method and compounds

Country Status (4)

Country Link
EP (1) EP1140070A1 (en)
AU (1) AU1877700A (en)
GB (1) GB9828640D0 (en)
WO (1) WO2000038675A1 (en)

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WO2001013916A1 (en) * 1999-08-20 2001-03-01 Sagami Chemical Research Center Drugs inhibiting cell death
CA2395284A1 (en) * 1999-12-23 2001-07-05 The Ontario Cancer Institute Inhibition of gsk-3.beta.
HUP0302002A3 (en) * 2000-05-11 2007-02-28 Consejo Superior Investigacion Heterocyclic inhibitors of glycogen synthase kinase gsk-3, their use and pharmaceutical compositions containing them
ES2166328B1 (en) * 2000-05-11 2003-09-16 Consejo Superior Investigacion HETEROCICLIC INHIBITORS OF ENZYME GSK 3 USEFUL IN THE TREATMENT OF NEURODEGENERATIVE AND HYPERPROLIFERATIVE PROCESSES
HUP0301431A2 (en) 2000-07-27 2003-08-28 F. Hoffmann-La Roche Ag. 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivativas as inhibitors of glycogen synthase kinase-3betha, process for their preparation and pharmaceutical compositions containing them
EP1698627A1 (en) 2000-09-15 2006-09-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en) 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
EP1334207A2 (en) * 2000-10-02 2003-08-13 Reddy US Therapeutics, Inc. Methods and compositions for the treatment of inflammatory diseases
US6645970B2 (en) 2000-11-07 2003-11-11 Novartis Ag Indolylmaleimide derivatives
BRPI0115193B1 (en) * 2000-11-07 2016-08-09 Novartis Ag indolylmaleimide derivatives, process for preparing them as well as pharmaceutical composition comprising them
ATE301661T1 (en) 2000-12-08 2005-08-15 Ortho Mcneil Pharm Inc MACROHETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS
ATE354573T1 (en) 2000-12-21 2007-03-15 Vertex Pharma ßPYRAZOLE COMPOUNDS THAT ARE SUITABLE AS PROTEIN KINASE INHIBITORS
GB0103031D0 (en) * 2001-02-07 2001-03-21 Smithkline Beecham Plc Novel treatment
EP2295550A3 (en) 2001-04-30 2011-12-14 Vertex Pharmaceuticals Incorporated Crystal structures of GSK-3beta protein and protein complexes and their use
WO2003024447A1 (en) * 2001-09-20 2003-03-27 Smithkline Beecham Corporation Inhibitors of glycogen synthase kinase-3
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
DE60236322D1 (en) 2001-12-07 2010-06-17 Vertex Pharma PYRIMIDIN-BASED COMPOUNDS AS A GSK-3 HEMMER
JP4237066B2 (en) * 2002-01-10 2009-03-11 エフ．ホフマン−ラ ロシュ アーゲー Use of a GSK-3β inhibitor in the manufacture of a drug to increase bone formation
SG159380A1 (en) 2002-02-06 2010-03-30 Vertex Pharma Heteroaryl compounds useful as inhibitors of gsk-3
EP1490093A4 (en) * 2002-03-01 2007-04-11 Novartis Vaccines & Diagnostic METHODS AND COMPOSITIONS FOR THE TREATMENT OF ISCHEMIA
KR100974770B1 (en) 2002-03-05 2010-08-06 일라이 릴리 앤드 캄파니 Purine Derivatives as Kinase Inhibitors
MXPA04008671A (en) 2002-03-08 2004-12-06 Lilly Co Eli Pyrrole-2, 5-dione derivatives and their use as gsk-3 inhibitors.
JP2005529918A (en) 2002-05-08 2005-10-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Substituted pyrroline kinase inhibitors
MY141867A (en) 2002-06-20 2010-07-16 Vertex Pharma Substituted pyrimidines useful as protein kinase inhibitors
EP1534389A2 (en) * 2002-07-23 2005-06-01 SmithKline Beecham Corporation Pyrazolopyrimidines as kinase inhibitors
CN1319968C (en) 2002-08-02 2007-06-06 沃泰克斯药物股份有限公司 Pyrazole compositions useful as inhibitors of GSK-3
RU2005122484A (en) 2002-12-18 2006-01-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) COMPOSITIONS USED AS PROTEINKINASE INHIBITORS
GB0303319D0 (en) 2003-02-13 2003-03-19 Novartis Ag Organic compounds
CA2520590A1 (en) 2003-03-27 2004-11-04 Janssen Pharmaceutica, N.V. Substituted pyrroline kinase inhibitors
CA2522712A1 (en) * 2003-04-18 2004-10-28 Kyowa Hakko Kogyo Co., Ltd. Nerve regenerating drug
CN1897950A (en) 2003-10-14 2007-01-17 惠氏公司 Fused aryl and heteroaryl derivatives and methods of use
US8048454B2 (en) * 2004-03-09 2011-11-01 Michael Martin Methods and compositions related to regulation of cytokine production by glycogen synthase kinase 3 (GSK-3)
EP1751133B1 (en) 2004-04-28 2010-04-14 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of rock and other protein kinases
EP1746886A1 (en) * 2004-05-12 2007-01-31 Bayer CropScience GmbH Plant growth regulation
EP1662259A1 (en) * 2004-11-25 2006-05-31 Cellzome Ag Use of Eph receptor inhibitors for the treatment of neurodegenerative diseases
CA2589127C (en) 2004-12-08 2013-02-05 Johannes Gutenberg-Universitat Mainz 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
EP1844787A4 (en) * 2005-01-18 2011-10-19 Univ Kyoto DRUGS FOR REGENERATION OF NERVE CELLS
WO2006117212A2 (en) 2005-05-04 2006-11-09 Develogen Aktiengesellschaft Use of gsk-3 inhibitors for preventing and treating pancreatic autoimmune disorders
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP2009513672A (en) 2005-10-31 2009-04-02 ブレインセルス，インコーポレイティド GABA receptor-mediated regulation of neurogenesis
JP5249770B2 (en) 2005-11-03 2013-07-31 バーテックス ファーマシューティカルズ インコーポレイテッド Aminopyridines useful as kinase inhibitors
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
ES2427247T3 (en) 2006-03-13 2013-10-30 Kyorin Pharmaceutical Co., Ltd. Aminoquinolones as GSK-3 inhibitors
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
ES2446269T3 (en) 2006-12-19 2014-03-06 The Board Of Trustees Of The University Of Illinois 3-Benzofuranyl-4-indolyl-maleimides as potent inhibitors of GSK-3 for neurodegenerative disorders
AU2008210455A1 (en) 2007-01-31 2008-08-07 Vertex Pharmaceuticals Incorporated 2-aminopyridine derivatives useful as kinase inhibitors
KR20090120510A (en) 2007-03-09 2009-11-24 버텍스 파마슈티칼스 인코포레이티드 Aminopyrimidines useful as protein kinase inhibitors
AU2008282156B2 (en) 2007-07-31 2014-07-17 Vertex Pharmaceuticals Incorporated Process for preparing 5-fluoro-1H-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof
CN101855228B (en) 2007-09-11 2012-10-24 杏林制药株式会社 Cyanoaminoquinolones and tetrazoloaminoquinolones as GSK-3 inhibitors
CN102344457B (en) 2007-09-12 2015-07-22 杏林制药株式会社 Spirocyclic aminoquinolones as GSK-3 inhibitors
WO2010006342A2 (en) * 2008-07-11 2010-01-14 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of gsk-3 genes
CN102215816A (en) 2008-09-03 2011-10-12 沃泰克斯药物股份有限公司 Co-crystals and pharmaceutical formulations comprising the same
EP2177510A1 (en) 2008-10-17 2010-04-21 Universität des Saarlandes Allosteric protein kinase modulators
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2343291A1 (en) 2009-12-18 2011-07-13 Johannes Gutenberg-Universität Mainz 3-(Indolyl)- or 3-(Azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
EP2474541A1 (en) 2010-12-23 2012-07-11 Johannes- Gutenberg-Universität Mainz Conjugated 3-(indolyl)- and 3-(azaindolyl)-4-arylmaleimide compounds and their use in tumor treatment
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
EP3187495A1 (en) 2015-12-30 2017-07-05 Johannes Gutenberg-Universität Mainz 3-(5-fluoroindolyl)-4-arylmaleimide compounds and their use in tumor treatment
AU2020218366A1 (en) 2019-02-08 2021-09-16 Frequency Therapeutics, Inc. Valproic acid compounds and Wnt agonists for treating ear disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (en) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituted pyrroles, their use for preparing medicaments and medicaments based thereon
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
JP3348859B2 (en) * 1995-11-20 2002-11-20 イーライ・リリー・アンド・カンパニー Protein kinase C inhibitor
WO1997041854A1 (en) * 1996-05-07 1997-11-13 The Trustees Of The University Of Pennsylvania Inhibitors of glycogen synthase kinase-3 and methods for identifying and using the same
US6153618A (en) * 1996-10-11 2000-11-28 Chiron Corporation Inhibitors of glycogen synthase 3 kinase

Also Published As

Publication number Publication date
WO2000038675A1 (en) 2000-07-06
EP1140070A1 (en) 2001-10-10
AU1877700A (en) 2000-07-31

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)