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PE20020295A1 - Composiciones de oxazolidinona, ampicilina y sulbactam - Google Patents

Composiciones de oxazolidinona, ampicilina y sulbactam

Info

Publication number
PE20020295A1
PE20020295A1 PE2001000643A PE2001000643A PE20020295A1 PE 20020295 A1 PE20020295 A1 PE 20020295A1 PE 2001000643 A PE2001000643 A PE 2001000643A PE 2001000643 A PE2001000643 A PE 2001000643A PE 20020295 A1 PE20020295 A1 PE 20020295A1
Authority
PE
Peru
Prior art keywords
sulbactam
ampicillin
phenyl
oxazolidinone
alcoxy
Prior art date
Application number
PE2001000643A
Other languages
English (en)
Inventor
Donald H Batts
Keiichi Hiramatsu
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE20020295A1 publication Critical patent/PE20020295A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • A61K31/43Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE REFIERE A UNA COMPOSICION CON ACTIVIDAD ANTIBACTERIAL DE AMPLIO ESPECTRO QUE COMPRENDE a)OXAZOLIDINONA DE FORMULA I; X ES O, S, SO, SO2, SNR11, NCOR11, SONR11, n ES 0-2; R ES H, ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO CON F, Cl, ALCOXI C1-C8, ACILOXIC1-C8, CH2-FENIL, CILOALQUILO C3-C6, AMINO, ALQUILAMINO C1-C8, DIALQUILAMINO C1-C8, ALCOXI C1-C6; R1 ES H, EXCEPTO CUANDO X ES O; R1 ES H, CH3, CN, CO2H, (CH2)mR10; m ES 1-2; R2 ES H, F, Cl; R3 ES H, EXCEPTO CUANDO X ES O Y R1 ES CH3; R3 ES H, CH3; R10 ES H, OH, OR, OCOR, NH2, NHCOR, N(R11)2; R11 ES H, p-TOLUENSULFONIL, ALQUILO C1-C4 OPCIONALMENTE SUSTITUIDO CON Cl, F, OH, ALCOXI C1-C8, AMINO, ALQUILAMINO C1-C8, DIALQUILAMINO C1-C8; SON COMPUESTOS PREFERIDOS LINEZOLID (200mg A 900mg), EPEREZOLID, (S)-N-[[3-[3-FLUORO-4-(TETRAHIDRO-2H-TIOPIRAN-4-IL)FENIL]-2-OXO-5-OXAZOLIDINIL]METIL]ACETAMIDAS, S,S DIOXIDO; (S)-N-[[3-[3,5-DIFLUORO-4-(TETRAHIDRO-2H-TIOPIRAN-4-IL)FENIL]-2-OXO-5-OXAZOLIDINIL]METIL]ACETAMIDA S,S DIOXIDO; b)AMPICILINA; c)SULBACTAM; d)EXCIPIENTES COMO MANITOL, ALMIDON, SILICE COLOIDAL, POVIDONA, ESTEARATO DE MAGNESIO. LA COMPOSICION SE CARACTERIZA PORQUE EL AGENTE ACTIVO ESTA RODEADO DE UN RECEPTACULO QUE COMPRENDE AL MENOS 50% DEL PESO EN POLIOLEFIN Y LA CANTIDAD ANTIBACTERIALMENTE POTENCIADORA DE SULBACTAM Y AMPICILINA ES DE 3.1mg A 6.2mg.
PE2001000643A 2000-06-30 2001-06-28 Composiciones de oxazolidinona, ampicilina y sulbactam PE20020295A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21541800P 2000-06-30 2000-06-30
US23277300P 2000-09-15 2000-09-15
US27930601P 2001-03-28 2001-03-28

Publications (1)

Publication Number Publication Date
PE20020295A1 true PE20020295A1 (es) 2002-04-07

Family

ID=27396119

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000643A PE20020295A1 (es) 2000-06-30 2001-06-28 Composiciones de oxazolidinona, ampicilina y sulbactam

Country Status (14)

Country Link
US (1) US6544991B2 (es)
EP (1) EP1301207B1 (es)
JP (1) JP2004501965A (es)
AR (1) AR029544A1 (es)
AT (1) ATE301474T1 (es)
AU (1) AU2001272961A1 (es)
DE (1) DE60112581T2 (es)
DK (1) DK1301207T3 (es)
ES (1) ES2245698T3 (es)
MY (1) MY128739A (es)
PE (1) PE20020295A1 (es)
PT (1) PT1301207E (es)
TW (1) TWI265030B (es)
WO (1) WO2002002095A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9928568D0 (en) 1999-12-03 2000-02-02 Zeneca Ltd Chemical compounds
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
WO2003030906A1 (en) * 2001-10-11 2003-04-17 Pharmacia & Upjohn Company Treating infections by administration of oxazolidinones to the skin
CN1642543A (zh) * 2002-03-29 2005-07-20 法玛西雅厄普约翰有限责任公司 治疗糖尿病性足部感染的噁唑烷酮肠胃外、静脉内和口服给药
WO2003093247A2 (en) * 2002-04-30 2003-11-13 Orchid Chemicals & Pharmaceuticals Ltd Antibacterial agents
JP2008540431A (ja) * 2005-05-06 2008-11-20 ワイス ヘパリンの存在下でのチゲサイクリンの送達
JP2008544979A (ja) 2005-06-29 2008-12-11 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてのホモモルホリンオキサゾリジノン
WO2007086013A1 (en) * 2006-01-25 2007-08-02 Jegannathan Srinivas Formulation comprising of ceftazidime, tazobactam and linezolid
WO2007086014A1 (en) * 2006-01-25 2007-08-02 Jegannathan Srinivas Formulation comprising cefpirome, tazobactam and linezolid
WO2007086011A1 (en) * 2006-01-25 2007-08-02 Jegannathan Srinivas Formulation comprising cefepime, tazobactam and linezolid
WO2007086012A1 (en) * 2006-01-25 2007-08-02 Jegannathan Srinivas Formulation of cefpodoxime, clavulanic acid and linezolid
WO2008090570A1 (en) * 2007-01-25 2008-07-31 Panacea Biotec Ltd Novel antimicrobials
KR20110092309A (ko) 2008-11-20 2011-08-17 파나세아 바이오테크 리미티드 신규 항균제
MX2012000231A (es) 2009-06-26 2012-03-07 Panacea Biotec Ltd Nuevos aza-biciclo-hexanos.
WO2017066964A1 (en) 2015-10-22 2017-04-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
WO2021184339A1 (en) 2020-03-20 2021-09-23 Merck Sharp & Dohme Corp. Oxazolidinone compound and methods of use thereof as an antibacterial agent

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
GB902703A (en) 1960-08-25 1962-08-09 Beecham Res Lab Penicillins
BE641785A (es) 1962-12-26
US4234579A (en) 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
SK283420B6 (sk) 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
US5688792A (en) 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE4425613A1 (de) 1994-07-20 1996-01-25 Bayer Ag 5-gliedrige Heteroaryl-oxazolidinone
DE4425612A1 (de) 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
DE19514313A1 (de) 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
ES2165516T3 (es) 1995-09-01 2002-03-16 Upjohn Co Feniloxazolidinonas con un enlace c-c con anillos heterociclicos de 4-8 miembros.
DE19601264A1 (de) 1996-01-16 1997-07-17 Bayer Ag Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone
DE19601265A1 (de) 1996-01-16 1997-07-17 Bayer Ag 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone
DE19601627A1 (de) 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
US5684024A (en) 1996-01-25 1997-11-04 Viropharma Incorporated Pyrazole dimers compositions and methods for treating influenza
DE19604223A1 (de) 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
ES2166073T3 (es) 1996-04-11 2002-04-01 Upjohn Co Procedimiento para preparar oxazolidinonas.
SK286569B6 (sk) 1997-11-07 2009-01-07 Pharmacia & Upjohn Company Spôsob výroby oxazolidinónov
KR20010101890A (ko) 1999-02-01 2001-11-15 로렌스 티. 마이젠헬더 황-함유 시클릭 플루오르화 옥사졸리디논의 제조 방법

Also Published As

Publication number Publication date
DK1301207T3 (da) 2005-10-10
EP1301207B1 (en) 2005-08-10
ES2245698T3 (es) 2006-01-16
PT1301207E (pt) 2005-11-30
US20020022610A1 (en) 2002-02-21
TWI265030B (en) 2006-11-01
DE60112581D1 (de) 2005-09-15
DE60112581T2 (de) 2006-06-01
US6544991B2 (en) 2003-04-08
ATE301474T1 (de) 2005-08-15
MY128739A (en) 2007-02-28
AR029544A1 (es) 2003-07-02
JP2004501965A (ja) 2004-01-22
AU2001272961A1 (en) 2002-01-14
WO2002002095A3 (en) 2003-02-06
WO2002002095A2 (en) 2002-01-10
WO2002002095B1 (en) 2004-03-25
EP1301207A2 (en) 2003-04-16

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