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PE20020589A1 - 5-SPIROPYRIMIDIN-2,4,6-TRIONA AS INHIBITORS OF METALOPROTEINASES - Google Patents

5-SPIROPYRIMIDIN-2,4,6-TRIONA AS INHIBITORS OF METALOPROTEINASES

Info

Publication number
PE20020589A1
PE20020589A1 PE2001001060A PE2001001060A PE20020589A1 PE 20020589 A1 PE20020589 A1 PE 20020589A1 PE 2001001060 A PE2001001060 A PE 2001001060A PE 2001001060 A PE2001001060 A PE 2001001060A PE 20020589 A1 PE20020589 A1 PE 20020589A1
Authority
PE
Peru
Prior art keywords
heteroaryl
aryl
alkyl
spiropyrimidin
triona
Prior art date
Application number
PE2001001060A
Other languages
Spanish (es)
Inventor
Brian Scott Bronk
Mark Carl Noe
Martin James Wythes
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20020589A1 publication Critical patent/PE20020589A1/en

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract

SE REFIERE A COMPUESTOS DE 5-ESPIROPIRIMIDIN-2,4,6-TRIONA FORMULA I DONDE A ES UN ANILLO HETEROCICLICO DE 5-7 MIEMBROS SELECCIONADOS DEL GRUPO a, b ENTRE OTROS DONDE R2, R2, R3, R4, R5, R6 SON H, ALQUILO C1-C4, ALQUENILO C1-C4, ALQUINILO C1-C4, ARILO C6-C10, HETEROARILO C1-C10, ENTRE OTROS; X ES ARILO C6-C10, HETEROARILO C1-C10, ENTRE OTROS; Y ES UN ENLACE O, S, C=O, S02, S=O, ENTRE OTROS; n ES 1-4; Z ES ARILO C6-C10, CICLOALQUILO C3-C8, HETEROCICLILO C1-C10, HETEROARILO C1-C10, ENTRE OTROS; G ES R15-(CR16R17)p SIENDO p 0-4; R15 ES HALO, CN, NO2, ENTRE OTROS; R16 Y R17 SON H, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS 1-[6-(4-[1,3,4]OXADIAZOL-2-ILFENOXI)PIRIDIN-3-IL]-1,8,10-TRIAZAESPIRO[5.5]UNDECAN-2,7,9,11-TETRAONA, 1-[6-(4-[1,3,4]OXADIAZOL-2-ILFENOXI)PIRIDIN-3-IL]-1,3,7,9-TRETRAZAESPIRO[4.5]DECAN-2,6,8,10-TETRAONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON INHIBIDORES DE METALOPROTEINASAS Y SON UTILES PARA EL TRATAMIENTO DE INFLAMACION, CANCERREFERS TO COMPOUNDS OF 5-SPIROPYRIMIDIN-2,4,6-TRIONA FORMULA I WHERE A IS A HETEROCYCLIC RING OF 5-7 SELECTED MEMBERS FROM GROUP a, b AMONG OTHERS WHERE R2, R2, R3, R4, R5, R6 ARE H, C1-C4 ALKYL, C1-C4 ALKENYL, C1-C4 ALKYL, C6-C10 ARYL, C1-C10 HETEROARYL, AMONG OTHERS; X IS C6-C10 ARYL, C1-C10 HETEROARYL, AMONG OTHERS; AND IT IS AN O, S, C = O, S02, S = O LINK, AMONG OTHERS; n IS 1-4; Z IS C6-C10 ARYL, C3-C8 CYCLOALKYL, C1-C10 HETERO CYCLYL, C1-C10 HETEROARYL, AMONG OTHERS; G IS R15- (CR16R17) p BEING p 0-4; R15 IS HALO, CN, NO2, AMONG OTHERS; R16 AND R17 ARE H, C1-C4 ALKYL. PREFERRED COMPOUNDS ARE 1- [6- (4- [1,3,4] OXADIAZOL-2-ILFENOXY) PYRIDIN-3-IL] -1,8,10-TRIAZAESPIRO [5.5] UNDECAN-2,7,9,11 -TETRAONE, 1- [6- (4- [1,3,4] OXADIAZOL-2-ILFENOXY) PYRIDIN-3-IL] -1,3,7,9-TRETRAZAESPIRO [4.5] DECAN-2,6,8 , 10-TETRAONA, AMONG OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION AND A PROCEDURE FOR THE PREPARATION. THE MENTIONED COMPOUNDS ARE INHIBITORS OF METALOPROTEINASES AND ARE USEFUL FOR THE TREATMENT OF INFLAMMATION, CANCER

PE2001001060A 2000-10-26 2001-10-25 5-SPIROPYRIMIDIN-2,4,6-TRIONA AS INHIBITORS OF METALOPROTEINASES PE20020589A1 (en)

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